Results 101 to 110 of about 28,196 (246)

Association Between Pruritus and Healthcare Utilization and Costs Among Individuals With Primary Biliary Cholangitis

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Background and Aims Pruritus is a debilitating, under‐prioritized symptom of primary biliary cholangitis (PBC). This study assessed its impact on healthcare resource utilization (HCRU) and costs in the US. Methods A retrospective cohort study of individuals with PBC was conducted using Komodo's claims and laboratory data between September 1 ...
Robert G. Gish, Michel H. Mendler, Edward A. Mena, Chong Kim, C. Fiorella Murillo Perez, Yi Pan, Lauren A. Do, Mihail Samnaliev, Maria Agapova   +8 more
wiley   +1 more source

Intrahepatic cholestasis of pregnancy [PDF]

РМЖ. Мать и дитя, 2019
P.V. Kozlov1, I.V. Samsonova2 1Pirogov Russian National Research Medical University, Moscow, Russian Federation 2City Clinical Hospital No. 52, Moscow, Russian Federation Intrahepatic cholestasis of pregnancy (ICP) is a reversible form of ...
P.V. Kozlov, I.V. Samsonova
doaj  

A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population [PDF]

, 2012
Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.
Grünhage, Frank, Krawczyk, Marcin, Lammert, Frank, Müllenbach, Roman, Sarrazin, Christoph, Weber, Susanne N., Zimmer, Vincent   +6 more
core   +1 more source

Hepatic Monoclonal Light‐ and Heavy‐Chain Deposition Disease Presenting as Noncirrhotic Portal Hypertension With Ascites

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Monoclonal immunoglobulin deposition disease (MIDD) is a plasma cell disorder where immunoglobulin light‐ and/or heavy‐chains accumulate in various organs. Hepatic involvement can be challenging to diagnose, as manifestations are protean and Congo red staining is negative.
Bella L. Liu, Helmut G. Rennke, Lei Zhao, Kayla R. Elliott, Yuxin Liu, Stephen D. Zucker   +5 more
wiley   +1 more source

Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy

Case Reports in Obstetrics and Gynecology, 2017
Intrahepatic cholestasis of pregnancy is seldom associated with significant vitamin K deficiency. We report a case of a 16-year-old primigravid patient at 24 weeks and 3 days of gestation who presented with pruritus, hematuria, and preterm labor ...
Maria Maldonado, Ali Alhousseini, Michael Awadalla, Jay Idler, Robert Welch, Karoline Puder, Manasi Patwardhan, Bernard Gonik   +7 more
doaj   +1 more source

Bile salt export pump deficiency disease: two novel, late onset, ABCB11 mutations identified by next generation sequencing

Annals of Hepatology, 2016
Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of autosomal recessive cholestatic diseases of childhood and represents the main indication for liver transplantation at this age; PFIC2 involves ABCB11 gene, that encodes the ...
Giovanni Vitale, Martina Pirillo, Vilma Mantovani, Elena Marasco, Adelia Aquilano, Nesrine Gamal, Paola Francalanci, Fabio Conti, Pietro Andreone   +8 more
doaj   +1 more source

Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials. [PDF]

, 2013
PurposePatients with advanced cholangiocarcinoma (CC) and gallbladder carcinoma (GC) have few therapeutic options for relapsed disease. methods: Given the overall poor prognosis in this population and the availability of novel targeted therapies, we ...
Falchook, Gerald S, Fu, Siqing, Hess, Kenneth R, Hong, David S, Janku, Filip, Javle, Milind, Kaseb, Ahmed O, Kurzrock, Razelle, Naing, Aung, Piha-Paul, Sarina, Subbiah, Ishwaria M, Subbiah, Vivek, Tsimberidou, Apostolia M, Wheler, Jennifer J, Wolff, Robert A   +14 more
core   +2 more sources

Relative Exchangeable and Exchangeable Copper: Emerging New Biomarkers for Diagnosis and Therapy Monitoring in Wilson's Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Wilson's disease (WD) is a genetic disorder of copper metabolism in which early diagnosis remains challenging, particularly in acute liver failure (ALF). Relative exchangeable copper (REC) and exchangeable copper (CuEXC) are emerging biomarkers for diagnosis and monitoring, but data from larger cohorts are limited.
Sebastian Köhrer, Antoan Rusev, Holger Zimmer, Silke Wolf, Jessica Langel, Andrea Langel, Thomas Longerich, Patrick Michl, Moritz Niesert, Alexander Fichtner, Isabelle Mohr   +10 more
wiley   +1 more source

Progressive familial intrahepatic cholestasis with normal GGT level appearing with lichenification and enlargement of hands and feet

The Turkish Journal of Pediatrics, 2005
Progressive familial intrahepatic cholestasis is a serious disease of the liver, known as Byler disease, characterized by hepatocellular cholestasis.
Tümay Doğanci, Gülen Akyol, Sevcan Bulaç   +2 more
doaj  

Clinical aspects of pregnancy and childbirth in women with intrahepatic cholestasis of pregnancy

One Health & Risk Management
Introduction. Intrahepatic cholestasis of pregnancy (ICP) is a liver pathology that has negative impact on progression of pregnancy and childbirth in affected women.
Maria CEMORTAN, Irina SAGAIDAC, Corina ILIADI-TULBURE, Olga CERNETCHI   +3 more
doaj   +1 more source