Results 81 to 90 of about 28,196 (246)
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Российский журнал гастроэнтерологии, гепатологии, колопроктологииAim: to analyse the principles of diagnosis and treatment of intrahepatic cholestasis in chronic liver diseases, to present data on the effectiveness of ademetionine in the treatment of chronic liver diseases with intrahepatic cholestasis and the ...
K. L. Raikhelson +6 more
doaj +1 more source
Portal Hypertension &Cirrhosis, EarlyView.In this biopsy‐controlled study, FibroTouch and FibroScan demonstrated comparable diagnostic accuracy for liver fibrosis staging (AUROCs > 0.900), but FibroTouch required consistently higher stiffness thresholds. These discrepancies were more pronounced in patients with MAFLD, highlighting the need for device‐specific cutoffs to avoid misclassification.
Min Wang +8 more
wiley +1 more source
Pregnancies in women with rare diseases: Selected maternal and perinatal outcomes
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.Pregnancies in women with rare diseases carry substantial disease‐related (23.2%) and pregnancy‐specific (25.1%) risks. Complication rates drop markedly when conditions are stable before conception. Abstract Introduction Rare diseases (RD) are characterized by chronicity and may be associated with reduced life expectancy and quality of life.
Philipp Kosian +6 more
wiley +1 more source
Genetic Cholestasis: Lessons from the Molecular Physiology of Bile Formation
Canadian Journal of Gastroenterology, 2000 Progressive familial intrahepatic cholestasis (PFIC) is a group of severe genetic cholestatic liver diseases of early life. PFIC types 1 and 2 are characterized by cholestasis and a low to normal serum gamma-glutamyltransferase (GGT) activity, whereas in
Peter LM Jansen, Michael Müller
doaj +1 more source
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2016 Intrahepatic cholestasis, a rare complication of sickle cell anemia, is characterized by marked hyperbilirubinemia, acute hepatic failure, and an often fatal course.
Nurhilal Buyukkurt +4 more
doaj +1 more source
Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis
Alimentary Pharmacology &Therapeutics, EarlyView.Serum conjugated primary bile acids accumulate in alcohol‐related hepatitis due to downregulation of hepatocyte bile acid transporters. Hepatocyte growth factor is elevated in alcohol‐related hepatitis and downregulates BSEP expression. This detrimentally affects the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis ...
Luke D. Tyson +22 more
wiley +1 more source
Annals of Hepatology, 2005 Hepatobiliary transport systems mediate hepatic uptake and biliary excretion of bile acids, bilirubin and other biliary constituents. Hereditary or acquired defects of these transporters may cause or maintain cholestasis and jaundice under various ...
Martin Wagner, Michael Trauner
doaj +1 more source
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Intrahepatic cholangiocarcinoma (iCCA) ranks as the second most common primary liver cancer, compared to about 20% of cases. Its global incidence has climbed over the past four decades, yet early detection remains indefinable due to its asymptomatic nature. Five‐year survival rate of approximately is under 10%.
Yaqoob Muhammad +10 more
wiley +1 more source