Results 61 to 70 of about 51,796 (192)

Benign recurrent intrahepatic cholestasis

, 2005
Benign recurrent intrahepatic cholestasis (BRIC) is a rare cause of cholestasis in children. The disease may start in infancy or early childhood.
Bhatia, Baldev D, Gupta, V, Kumar, M
core   +1 more source

Dental management of a patient with progressive familial intrahepatic cholestasis [PDF]

, 2013
Progressive familial intrahepatic cholestasis refers to a heterogenous group of autosomal recessive disorders in which children develop severe intrahepatic cholestasis progressing to biliary cirrhosis and chronic liver failure, usually during the first ...
Khounganian, Rita, AbuBotain, Hala
core   +1 more source

Intrahepatic cholestasis in chronic liver disease

, 1996
Cholestasis syndromes are characterized by a reflux of compounds usually excreted with bile. ATP dependent carriers and cytoskeleton proteins guarantee physiological bile flux.
Pezzoli A., Fabbri C., Marchetto S., Roda E., Fusaroli P., Azzaroli F., Mazzella G., Jaboli F.   +7 more
core   +1 more source

Chronic Kidney Disease‐Associated Pruritus Is Linked to Selective Enrichment of Taurine‐Conjugated Bile Acid Subspecies

JEADV Clinical Practice, EarlyView.
Chronic kidney disease‐associated pruritus (CKDaP) is a frequent complication of advanced CKD with an incompletely understood pathophysiology. We identified a significantly altered glycine‐to‐taurine conjugated bile acid ratio in patients with CKDaP despite unchanged total serum bile acid concentrations.
Miriam M. Düll, Manfred Rauh, Peter Dietrich, Marcel Vetter, Jonas Schmid, Thomas Mettang, Andreas E. Kremer   +6 more
wiley   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

A novel case report of benign recurrent intrahepatic cholestasis-associated USP53 genetic mutation in a Pakistani girl

SAGE Open Medical Case Reports
Benign recurrent intrahepatic cholestasis is an autosomal recessive disorder presenting with intermittent episodes of cholestatic jaundice. The initial episode of benign recurrent intrahepatic cholestasis tends to occur within the first two decades of a ...
Tafiya Erum Kamran, Seyreen Faisal, Rimsha Khalid, Zaira Haider, Rida Inam, Yusra Siddiqui, Munir Iqbal, Sabeen Abid Khan   +7 more
doaj   +1 more source

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

VIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi, Xipei Huang, Wutao Chen, Wen Di, Lin Huang, You Wang   +5 more
wiley   +1 more source

Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy [PDF]

, 2010
Intrahepatic cholestasis of pregnancy and drug-induced cholestasis are two clinically important forms of acquired cholestatic liver disease. The understanding of the underlying mechanisms of acquired cholestasis has recently made considerable progress by
Meier, Peter J, Stieger, Bruno, Pauli-Magnus, Christiane   +2 more
core   +1 more source

Intrahepatic cholestasis following treatment with fluconazole [PDF]

, 1995
We report the postmortem findings of two parients with intrahepatic cholestasis following treatment with fluconazole, an antifungal drug. In both patients, the serum bilirubin and alkaline phosphatase levels rose abruptly after fluconazole treatment ...
Toru URANO, Yuro SHIBAYAMA, Kosaku ODA, Katashi NARIYAMA, Ryotaro KAYO, Keiichi FUKUNISHI, Atsuko TSUJI, Emi YASUDA, Shosaku ASAKA, Teisuke MATSUMIYA   +9 more
core   +1 more source