Results 61 to 70 of about 105,725 (272)

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells [PDF]

, 2017
Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure.
Harada Kazuo, Hirata Kazumasa, Imagawa Kazuo, Isoyama Shigemi, Kage Masayoshi, Kawabata Kenji, Mizuguchi Hiroyuki, Noguchi Emiko, Sakurai Fuminori, Shinkai Masato, Sumazaki Ryo, Tachibana Masashi, Takayama Kazuo, Tanikawa Ken, 今川 和生, 野口 惠美子   +15 more
core   +1 more source

Assessment of aspartate aminotransferase to Platelet Ratio Index and Fibrosis-4 Index score on women with intrahepatic cholestasis of pregnancyAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: Intrahepatic cholestasis of pregnancy is a pregnancy-related liver condition that is characterized by elevated liver function tests and/or bile acids in the presence of pruritis.
Maria Cemortan, PhD, Corina Iliadi-Tulbure, PhD, Irina Sagaidac, PhD, Olga Cernetchi, PhD   +3 more
doaj   +1 more source

A New Mutation Causing Progressive Familiar Intrahepatic Cholestasis Type 3 in Association with Autoimmune Hepatitis [PDF]

, 2017
Background: Some patients exhibit features of both autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). Similarly, patients with progressive familial intrahepatic cholestasis type 3 (PFIC3) may share histological features with PSC.
Oliveira, Hugo M., Pereira, Cláudia, Pessegueiro-Miranda, Helena, Pinto-Basto, Jorge, Santos-Silva, Ermelinda, Vizcaíno, José R.   +5 more
core   +3 more sources

Coexisting Sickle Cell Anemia and Sarcoidosis: A Management Conundrum! [PDF]

, 2017
Sickle cell disease and Sarcoidosis are conditions that are more common in the African American population. In this report we share an unfortunate patient who had hepatic sarcoidosis but could not receive steroids since that precipitated acute liver ...
Gollahalli, Nagesh S., Nutan, FNU
core   +3 more sources

Prevalence and risk factors of intrahepatic cholestasis of pregnancy in a Chinese population

Scientific Reports, 2020
Studies on the risk factors for intrahepatic cholestasis of pregnancy (ICP) in a population-based cohort are lacking. We assess the prevalence and risk factors of ICP in a Chinese population.
X. Gao, M. Ye, Yan Liu, Jin-Yan Li, Li Li, Wei Chen, Xue-zheng Lu, G. Nie, Yuan-Hua Chen   +8 more
semanticscholar   +1 more source

The debut of benign recurrent intrahepatic cholestasis in acute hepatitis A

Трансплантология (Москва)
Background. Benign recurrent intrahepatic cholestasis is a rare inherited disorder characterized by recurrent episodes of severe hyperbilirubinemia and pruritus that resolve spontaneously.
K. Yu. Kokina, Yu. O. Malinovskaya, O. V. Sumtsova, A. O. Grigorevskaya, Ya. G. Moysyuk   +4 more
doaj   +1 more source

An Insight Into Neonatal Cholestasis; A Tertiary Care Hospital Experience in Rawalpindi, Pakistan

Pakistan Armed Forces Medical Journal, 2023
Objective: To determine the frequencies of various etiologies of neonatal cholestasis diagnosed by clinical findings and laboratory investigations at the Pak Emirates Military Hospital, Rawalpindi, Pakistan.
Sughra Azhar, Farooq Ikam, Sarina Zainab Shirazi, Junaid Altaf, Rahmeen Pervaiz   +4 more
doaj   +1 more source

Molecular overview of progressive familial intrahepatic cholestasis

World Journal of Gastroenterology, 2020
Cholestasis is a clinical condition resulting from the imapairment of bile flow. This condition could be caused by defects of the hepatocytes, which are responsible for the complex process of bile formation and secretion, and/or caused by defects in the ...
Sriram Amirneni, Nils Haep, M. A. Gad, A. Soto‐Gutierrez, J. Squires, R. Florentino   +5 more
semanticscholar   +1 more source

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, EarlyView.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Dental management of a pediatric patient with progressive familial intrahepatic cholestasis having dental anomalies: a case report and brief review of the literature

BMC Oral Health, 2023
Background Progressive familial intrahepatic cholestasis is a heterogeneous group of disorders, leading to intrahepatic cholestasis, with the possibility of chronic liver failure and biliary cirrhosis.
Mina Yazdizadeh, Maryam Sharifi, Arefeh Torabi Parizi, Firoozeh Alipour, Maryam Ghasempuor, Elham Zanguei, Maryam Yazdizadeh   +6 more
doaj   +1 more source