Results 71 to 80 of about 105,725 (272)

Fatal intrahepatic cholestasis

The Turkish Journal of Pediatrics, 1976
A Gürgey, S Ozsoylu, N Koçak
doaj   +2 more sources

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel. [PDF]

, 2019
Pexidartinib (PLX3397) is a small molecule tyrosine kinase and colony-stimulating factor-1 inhibitor with FDA breakthrough therapy designation for tenosynovial giant-cell tumor, and currently under study in several other tumor types, including breast ...
Chien, A Jo, Esserman, Laura J, Hyland, Colby, Piawah, Sorbarikor, Rugo, Hope S, Umetsu, Sarah E   +5 more
core  

Ursodeoxycholic acid for treatment of cholestasis in patients with hepatic amyloidosis [PDF]

, 2009
Background. Amyloidosis represents a group of different diseases characterized by extracellular accumulation of pathologic fibrillar proteins in various tissues and organs.
Akoglu Bora, Faust Dominik, Milović Vladan, Ristić Gordana   +3 more
core   +1 more source

INTRAHEPATIC CHOLESTASIS IN PREGNANCY [PDF]

Praxis medica, 2013
<p>Abnormal liver function tests occur in 3-5% of pregnancies, with many potential causes, including coincidental liver disease (most commonly viral hepatitis or gallstones) and underlying chronic liver disease. Pruritus in pregnancy is common, affecting 23% of pregnancies, of which a small proportion will have obstetric cholestasis ...
Savić Ž., Stojilković T., Rankov O., Vračarić V., Jocić T., Damjanov D.   +5 more
openaire   +2 more sources

Potential of ileal bile acid transporter inhibition as a therapeutic target in Alagille syndrome and progressive familial intrahepatic cholestasis

Liver international (Print), 2020
Alagille syndrome (ALGS) and progressive familial intrahepatic cholestasis (PFIC) are rare, inherited cholestatic liver disorders that manifest in infants and children and are associated with impaired bile flow (ie cholestasis), pruritus and potentially ...
B. Kamath, Philip Stein, R. Houwen, H. Verkade   +3 more
semanticscholar   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Benign Recurrent Intrahepatic Cholestasis: Where Are We Now?

Gastroenterology Insights
Benign recurrent intrahepatic cholestasis (BRIC) stands as a rare genetic contributor to cholestasis, aligning itself within the spectrum of inherited intrahepatic cholestasis syndromes, such as progressive familial intrahepatic cholestasis (PFIC) and ...
Eleni V. Geladari, Natalia G. Vallianou, Evangelia Margellou, Dimitris Kounatidis, Vassilios Sevastianos, Alexandra Alexopoulou   +5 more
doaj   +1 more source

Intrahepatic cholestasis of pregnancy: Case series of a rare disease in an African setting

SAGE Open Medical Case Reports, 2022
Intrahepatic cholestasis of pregnancy commonly presents in the second and third trimester with unexplained pruritus sine materia , abnormal liver function tests, and/or elevated serum total bile acid concentration.
Davis Rubagumya, Miriam Mgonja, Munawar Kaguta, Ahmed Jusabani, Muzdalfat Abeid, Nancy Matillya   +5 more
doaj   +1 more source

Interventions for treating cholestasis in pregnancy (Review) [PDF]

, 2013
BACKGROUND: Obstetric cholestasis has been linked to adverse maternal and fetal/neonatal outcomes. As the pathophysiology is poorly understood, therapies have been empiric.
Gurung, Vinita, Hague, William, Middleton, Philippa, Milan, Stephen J., Stokes, Michael, Thornton, Jim   +5 more
core   +1 more source

Benign recurrent intrahepatic cholestasis

Definitions, 2020
Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodes of liver dysfunction called cholestasis. During these episodes, the liver cells have a reduced ability to release a digestive fluid called bile.
Alexander K. C. Leung, M. Schmitt, Christie P. Thomas, Cord Sunderkötter, M. Schiller, Thomas Schwarz, M. Berneburg, A. Kohlschütter, Lorenzo Cerroni, H. Direşkeneli, Kenneth Calamia, Gloria L. David, D. Zeldin, B. Schütte, Lee A. Denson, Andreas Erhardt, Ralf Kubitz, D. Häussinger, W. Sealey, Donald M. Mock, Barry Wolf, Johannes Schumacher, P. Propping, D. Metze, Andrew L. Wong, M. Hengstschläger, Whitney A. High, Kenneth R Shroyer, M. E. Mccready, Dennis E. Bulman, Ali R. Afzal, David B. Everman, C. Stoll, S. Darcan, Y. Kou, You Shuei Lin, Yoichi Suzuki, Keiya Tada, S. Kupka, Wolfgang Dietmaier, Arndt Hartmann, R. Hennekam, J. Belperio, Michael P. Keane, M. Iain Smith, Robert M. Strieter, Nestor A. Molfino, F. Sciandra, T. Rossenbacker, S. Priori, Marco Senzolo, C. Triantos, Dimitrios Samonakis, E. Cholongitas, A. Burroughs, Marco Mura, Markus Braun-Falco, S. Hofmann, Leena Bruckner‐Tuderman   +58 more
semanticscholar   +1 more source