Results 81 to 90 of about 105,725 (272)

Risk Factors for Small‐for‐Size Syndrome Grade B/C After Simultaneous Splenectomy in Adult Living‐Donor Liver Transplantation

Annals of Gastroenterological Surgery, EarlyView.
In a single‐center cohort of 577 adult LDLT recipients who underwent simultaneous splenectomy, clinically significant SFSS grade B/C (ILTS‐iLDLT‐LTSI 2023) occurred in 18.2% and was associated with inferior graft survival. Multivariate analysis identified MELD ≥ 30, NLR ≥ 4.5, and donor age ≥ 50 years as independent risk factors, which risk rising ...
Kyohei Yugawa, Takeo Toshima, Shinji Itoh, Takashi Motomura, Shohei Yoshiya, Norifumi Iseda, Tomoharu Yoshizumi   +6 more
wiley   +1 more source

Cholestasis syndrome in a comorbid patient: diagnostic difficulties

Медицинский совет, 2019
The purpose of the review article is to demonstrate generalized ideas on the classification and diagnosis of cholestasis syndrome of various etiologies, to consider the possibility of using laboratory and instrumental research methods in real clinical ...
E. V. Vinnitskaya, T. Yu. Khaymenova, K. G. Saliev, E. S. Skibkina, K. G. Absandze, Yu. G. Sandler   +5 more
doaj   +1 more source

A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population [PDF]

, 2012
Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.
Grünhage, Frank, Krawczyk, Marcin, Lammert, Frank, Müllenbach, Roman, Sarrazin, Christoph, Weber, Susanne N., Zimmer, Vincent   +6 more
core   +1 more source

Variants in AKR1D1 and Infant Mortality: Should Bile Acid Screening be a Routine Part of Newborn Screening?

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic pathogenic variants in AKR1D1 cause Δ4‐3‐oxosteroid 5β‐reductase deficiency, disrupt bile acid synthesis, and result in Congenital Bile Acid Synthesis defect type 2 (CBAS2). CBAS2 presents in infancy with cholestasis, coagulopathy, and failure to thrive.
Jade Hudson, Stephanie Hyunh, Bojana Rakic, Cornelius Boerkoel   +3 more
wiley   +1 more source

Baboon-to-human liver transplantation [PDF]

, 1993
Our ability to control both the cellular and humoral components of xenograft rejection in laboratory experiments, together with an organ shortage that has placed limits on clinical transplantation services, prompted us to undertake a liver ...
A Tzakis, A Zeevi, A Zeevi, A.J Demetris, A.J Demetris, Alper, Asonuma, Bailey, Barnard, Cano, Crawford, Essex, Francavilla, H Doyle, Hasan, Hitchcock, I.R Marino, Iwaki, J Fung, Jacobson, Karpas, Kelly, M Michaels, M Trucco, M Trucco, Moran, Porter, S Kusne, S Kusne, S Todo, Starzl, Starzl, Starzl, Starzl, Starzl, T.E Starzl, Takaya, Todo, Tzakis, V Warty, V Warty, W.A Rudert, W.A Rudert, Wolpl   +43 more
core   +1 more source

Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial

The Lancet, 2019
Summary Background Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth, and neonatal unit admission.
L. Chappell, Jennifer L. Bell, Anne Smith, L. Linsell, E. Juszczak, P. Dixon, J. Chambers, R. Hunter, J. Dorling, C. Williamson, J. Thornton, Irshad Rita Virginia Amarnath Heather George Helen Nishig Ahmed Arya Beckett Bhide Brown Bugg Cameron Deole , I. Ahmed, R. Arya, V. Beckett, A. Bhide, H. Brown, G. Bugg, H. Cameron, N. Deole, M. Dey, J. Dwyer, L. Fahel, R. Gada, J. Girling, A. Haestier, S. Hughes, R. Indusekhar, B. Jones, R. Khan, A. Kirkpatrick, E. Knox, K. Lincoln, M. Macdougall, F. Majoko, K. McIntyre, M. Noori, W. Oakley, Jane Preston, P. Ranka, M. Rashid, M. Salloum, M. Samyraju, C. Schram, S. Sen, S. Stone, B. Tan   +46 more
semanticscholar   +1 more source

Burden of Liver Disease Among Individuals With Turner Syndrome and Klinefelter Syndrome: A Comprehensive Perspective

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The liver is increasingly recognized as a major regulator of systemic cardio‐renal‐metabolic health. Evidence is mounting that sex‐chromosome dosage per se itself, independent of gonadal sex hormones, modulates hepatic physiology and liver disease risk.
Mohamad Jamalinia, Amedeo Lonardo, Ralf Weiskirchen   +2 more
wiley   +1 more source

Serum cystatin C measurement in differential diagnosis of intra and extrahepatic cholestatic diseases

Annals of Hepatology, 2010
Objective. Cystatin C is a very potent inhibitor of cysteine proteinases and, it has been clinically applied as a sensitive marker in monitoring of renal and liver functions.
Mehmet Buyukberber, Dr., Irfan Koruk, Oztekin Cýkman, Mehmet Koruk, Mehmet Emin Küçükoglu, Abdullah Sakman, Omer Demir, Saime Sahinoz   +7 more
doaj   +1 more source

A 19-year-old Patient with Recurrent Pruritus and Jaundice

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2023
Аim: to highlight the importance of broad differential diagnosis and possibility of conversion of benign recurrent intrahepatic cholestasis type 2 into more aggressive clinical phenotype.Key points. A 19-year-old female patient was admitted to the Clinic
K. S. Nezhdanov, E. N. Shirokova, Yu. O. Shulpekova, A. S. Ostrovskaya, M. S. Zharkova, V. T. Ivashkin   +5 more
doaj   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source