Results 31 to 40 of about 9,669 (210)

Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis

Medicine, 2017
Azithromycin-induced liver injury has been rarely reported in adult individuals, let alone in a pregnant woman. Here, we describe the clinical features and outcomes of azithromycin-induced liver injury in a pregnant woman.A 30-year-old pregnant woman presented with generalized pruritus and elevated serum bile acid level (123.6 μmol/L) on day 4 of ...
Han, Baoshi, Sheng, Yan, Wang, Li, Feng, Hao, Hou, Xianzeng, Li, Yan   +5 more
openaire   +2 more sources

Case Report: A 31-year-old Post Cesarean Section Women with Intrahepatic Cholestasis of Pregnancy and Post Partum Bell’s Palsy

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Intrahepatic cholestasis of pregnancy (ICP) is cholestasis condition characterized by pruritus, elevated serum aminotransferase and bile acid levels with onset in the second or third trimester of pregnancy. Estimated of ICP prevalence only 0.001% to 0.3%.
Syifa Mustika, RC Tarigan
doaj   +1 more source

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Nature Communications, 2022
Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.
Peter H. Dixon, Adam P. Levine, Inês Cebola, Melanie M. Y. Chan, Aliya S. Amin, Anshul Aich, Monika Mozere, Hannah Maude, Alice L. Mitchell, Jun Zhang, NIHR BioResource, Genomics England Research Consortium Collaborators, Jenny Chambers, Argyro Syngelaki, Jennifer Donnelly, Sharon Cooley, Michael Geary, Kypros Nicolaides, Malin Thorsell, William M. Hague, Maria Cecilia Estiu, Hanns-Ulrich Marschall, Daniel P. Gale, Catherine Williamson   +23 more
doaj   +1 more source

Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy [PDF]

, 2009
Background:An estimated two-thirds of the world\u27s 3.2 million stillbirths occur antenatally, prior to labour, and are often overlooked in policy and programs.
Esme V Menezes, Gary L Darmstadt, Mohammad Yakoob, Rachel A Haws, Tanya Soomro, Zulfiqar A Bhutta   +5 more
core   +2 more sources

Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy

Clinical and Experimental Obstetrics & Gynecology
Background: We conducted this study to investigate adverse pregnancy outcomes of hepatitis B virus infection coexistng with intrahepatic cholestasis in pregnant women, along with identifying associated risk factors.
Chong Zhang, Hong Wei, Zhiqiang Zhao, Yunxia Zhu   +3 more
doaj   +1 more source

Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy

Case Reports in Obstetrics and Gynecology, 2017
Intrahepatic cholestasis of pregnancy is seldom associated with significant vitamin K deficiency. We report a case of a 16-year-old primigravid patient at 24 weeks and 3 days of gestation who presented with pruritus, hematuria, and preterm labor ...
Maria Maldonado, Ali Alhousseini, Michael Awadalla, Jay Idler, Robert Welch, Karoline Puder, Manasi Patwardhan, Bernard Gonik   +7 more
doaj   +1 more source

Feto-Maternal outcomes in Intrahepatic Cholestasis in Pregnancy in a Tertiary Care Centre in Eastern Nepal

Journal of Nobel Medical College, 2016
Background Intrahepatic cholestasis of pregnancy has poor feto-maternal outcomes. To date there has been sparse publications regarding impact of intrahepatic cholestasis in feto-maternal outcomes in our setting.
Sita Pokhrel Ghimire, Ashima Ghimire, Gauri Shankar Jha, Manisha Chhetry, Mahanand Kumar   +4 more
doaj   +1 more source

Interventions for treating cholestasis in pregnancy (Review) [PDF]

, 2013
BACKGROUND: Obstetric cholestasis has been linked to adverse maternal and fetal/neonatal outcomes. As the pathophysiology is poorly understood, therapies have been empiric.
Gurung, Vinita, Hague, William, Middleton, Philippa, Milan, Stephen J., Stokes, Michael, Thornton, Jim   +5 more
core   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population [PDF]

, 2012
Background: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.
Grünhage, Frank, Krawczyk, Marcin, Lammert, Frank, Müllenbach, Roman, Sarrazin, Christoph, Weber, Susanne N., Zimmer, Vincent   +6 more
core   +1 more source