Results 51 to 60 of about 165,982,891 (200)

Clinical aspects of pregnancy and childbirth in women with intrahepatic cholestasis of pregnancy

One Health & Risk Management
Introduction. Intrahepatic cholestasis of pregnancy (ICP) is a liver pathology that has negative impact on progression of pregnancy and childbirth in affected women.
Maria CEMORTAN, Irina SAGAIDAC, Corina ILIADI-TULBURE, Olga CERNETCHI   +3 more
doaj   +1 more source

A Case of Markedly Elevated Isolated Alkaline Phosphatase in the Third Trimester of Pregnancy

Case Reports in Obstetrics and Gynecology, 2022
Background. Alkaline phosphatase (ALP) is an enzyme produced by the liver, small intestine, bone, and kidneys as well as the placenta during pregnancy. ALP levels may increase up to twice the normal limit during pregnancy secondary to placental release ...
Courtney T. Connolly, Olivia Grubman, Zainab Al-Ibraheemi, Tatyana Kushner   +3 more
doaj   +1 more source

Intrahepatic cholestasis of pregnancy: case report

Revista Médica de Minas Gerais, 2023
Objective: to report the pregnancy outcome of a patient with intrahepatic cholestasis treated at a public service in northern Brazil. Case Report: primiparous, 24 years old, mixed race, gestational age of 29 weeks, referred intense body pruritus ...
Rodolfo Ribeiro de Jesus, Marinalva Silva de Souza   +1 more
doaj   +1 more source

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

VIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi, Xipei Huang, Wutao Chen, Wen Di, Lin Huang, You Wang   +5 more
wiley   +1 more source

Genetic Spectrum of Cholestasis in Tunisia and Diagnostic Yield of Next‐Generation Sequencing: Case Series of 70 Patients

Clinical Genetics, EarlyView.
Genetic hepatic cholestasis: NGS diagnostic yield. Over a 10‐year period, NGS (gene panel/WES) established a genetic diagnosis in 70% of 66 families with hepatic cholestasis, with a molecular yield of 62%. ABCB11 was the most mutated gene, and PFIC Type 2 was the leading diagnosis, underscoring the critical role of NGS in guiding genetic counseling and
Amal Abdmouleh, Houweyda Jilani, Imen Rejeb, Syrine Hizem, Nicolas Pottier, Romain Larrue, Wendy Arondal, Lucie Hanquet, Rania Benrabeh, Olfa Bouyahia, Sonia Mazigh, Yasmina Elaribi, Lamia Benjemaa   +12 more
wiley   +1 more source

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.

PLoS ONE, 2020
INTRODUCTION:Previous studies of fetal effects have suggested that intrahepatic cholestasis of pregnancy is associated with a higher rate of adverse neonatal outcomes including preterm birth, neonatal respiratory distress syndrome, meconium-stained ...
Chloé Arthuis, Caroline Diguisto, Henri Lorphelin, Vincent Dochez, Emmanuel Simon, Franck Perrotin, Norbert Winer   +6 more
doaj   +1 more source

Rare Variants in PFIC‐Related Genes Among Adults With Intrahepatic Cholestasis

Hepatology Research, EarlyView.
ABSTRACT Aim Biallelic pathogenic variants in progressive familial intrahepatic cholestasis (PFIC)‐related genes cause severe pediatric cholestasis. However, the clinical significance of heterozygous variants in adult intrahepatic cholestasis remains unclear.
Shunji Hirose, Kota Tsuruya, Yusuke Mishima, Yoshitaka Arase, Koichi Shiraishi, Vu Thi Hao, Satsuki Ieda, Masayuki Tanaka, Sanae Isaki, Tatehiro Kagawa   +9 more
wiley   +1 more source

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source

Clinical and biochemical factors associated with insulin therapy in gestational diabetes: The role of OGTT‐based groups

Experimental Physiology, EarlyView.
Abstract Gestational diabetes mellitus (GDM) represents one of the most common metabolic disorders of pregnancy. This study aimed to identify clinical and biochemical factors associated with antenatal insulin therapy, focusing on the association with oral glucose tolerance test (OGTT)‐based phenotypes. Retrospective observational study among GDM women,
Libera Troìa, Martina Garassino, Riccardo Bertinato, Caroline Leitao Thomaz, Giulia Turatello, Chiara Airoldi, Alessandro Libretti, Daniela Surico, Valentino Remorgida   +8 more
wiley   +1 more source

Azathioprine associated with intrahepatic cholestasis in a patient with twin pregnancy after a second kidney transplant

European Journal of Case Reports in Internal Medicine
Introduction: Most pregnancies in women after a kidney transplant result in a live birth, but kidney functions should be stable for one year before conception. For immunosuppression modification occurring before pregnancy, azathioprine is used because it
Lamis Khedr, Mohamed Ekram
doaj   +1 more source