Results 61 to 70 of about 165,982,891 (200)

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

Canadian Journal of Gastroenterology and Hepatology, 2018
Cholestasis is characterised by impaired bile secretion and accumulation of bile salts in the organism. Hereditary cholestasis is a heterogeneous group of rare autosomal recessive liver disorders, which are characterised by intrahepatic cholestasis ...
Eva Sticova, Milan Jirsa, Joanna Pawłowska   +2 more
doaj   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

INTRAHEPATIC CHOLESTASIS OF PREGNANCY: THREE NOVEL MDR3 GENE MUTATIONS

, 2006
The aetiology of intrahepatic cholestasis of pregnancy is unknown, but more than 10 different MDR3 gene mutations have recently been identified.To evaluate the genetic contribution of the MDR3 gene in the pathogenesis of intrahepatic cholestasis of ...
ESPOSITO W, BRAGHIN C, CALDERI I., SOARDO G, MAZZELLA G., VARIOLA A., PATERNOSTER D., FLOREANI, ANNAROSA, TOMMASI A. M., MARCHESONI D, TOMMASI A. M, AZZAROLI F., BRAGHIN C., CARDERI, ISABELLA, VARIOLA A, ESPOSITO W., FLOREANI A., MARCHESONI, Diego, PATERNOSTER D, AZZAROLI F, SOARDO G.   +20 more
core   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, Volume 78, Issue 10, Page 1510-1521, October 2026.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Postpartum Blood Loss in Women Treated for Intrahepatic Cholestasis of Pregnancy [PDF]

, 2016
OBJECTIVE To evaluate postpartum blood loss in women with treated intrahepatic cholestasis of pregnancy. METHODS In a retrospective case-control study, 15,083 deliveries including 348 women with intrahepatic cholestasis of pregnancy (2.3%) were ...
Haslinger, Christian, Furrer, Romana, Zimmermann, Roland, Romana Furrer, Katharina Winter, Tilo Burkhardt, Burkhardt, Tilo, Winter, Katharina, Schäffer, Leonhard, Leonhard Schäffer, Roland Zimmermann, Christian Haslinger   +11 more
core   +1 more source

A Prospective Cohort Study to Determine the Incidence of IHCP and Pregnancy Outcome in Women with Cholestasis of Pregnancy Type of article

Gynecology Obstetrics & Reproductive Medicine
OBJECTIVE: This study was conducted to determine the incidence and outcomes of obstetric cholestasis in pregnancy. STUDY DESIGN: This was a hospital-based, observational, prospective cohort study conducted among antenatal women in the late second ...
Dhume Pranjali, Chawla Sunil, Madhumidha Gunasekaran, Sameena Parikh, Goel Suyash, Shah Ankur   +5 more
doaj   +1 more source

Long‐Term Safety and Efficacy of Obeticholic Acid in Patients With Primary Biliary Cholangitis: Final Results of the POISE Long‐Term Safety Extension

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1083-1096, October 2026.
In the POISE open‐label extension, patients with primary biliary cholangitis with inadequate response or intolerance to ursodeoxycholic acid received long‐term obeticholic acid (OCA) treatment. Findings demonstrated a safety profile consistent with the known characteristics of OCA, with no unexpected safety signals, while supporting sustained efficacy ...
Christopher L. Bowlus, Frederik Nevens, Kris V. Kowdley, Alan Bonder, Thomas Capozza, Jing Li, Radhika Nair, Michael Trauner, David E. Jones   +8 more
wiley   +1 more source

Differential diagnosis of the pruritus in intrahepatic cholestasis of pregnancy and other specific dermatoses of pregnancy [PDF]

, 2020
Department of Obstetrics and Gynecology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020Introduction.
Butucel, Ana
core   +1 more source

The impact of assisted reproductive technology in twin pregnancies complicated by intrahepatic cholestasis: a five-year retrospective study

BMC Pregnancy and Childbirth, 2022
Background Intrahepatic cholestasis of pregnancy is one of the common complications during pregnancy, and ursodeoxycholic acid has been recommended as the first-line drug.
Qianwen Zhang, Yu Xu, Yunhui Gong, Xinghui Liu   +3 more
doaj   +1 more source

Global Burden of Meconium‐Stained Amniotic Fluid: A Systematic Review and Meta‐Analysis of Prevalence With Descriptive Synthesis of Determinants

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Meconium‐stained amniotic fluid (MSAF) is a common intrapartum finding associated with adverse perinatal outcomes. Comprehensive global estimates of its prevalence and determinants are lacking. This systematic review and meta‐analysis aimed to estimate the global pooled prevalence of MSAF and classify its associated factors.
Shervin Tabrizian, Tiba Mirzarahimi, Mojgan Mirghafourvand, Mahsan Nabighadim   +3 more
wiley   +1 more source