Results 1 to 10 of about 140,719 (196)
Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery
Pharmaceutics, 2023 Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong +2 more
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Journal of Neuroendocrinology, 2021 Abstract The intranasal (IN) route enables the delivery of insulin to the central nervous system in the relative absence of systemic uptake and related peripheral side effects. Intranasally administered insulin is assumed to travel along olfactory and adjacent pathways and has been shown to rapidly accumulate in cerebrospinal fluid ...
M. Hallschmid
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Pharmaceutics, 2022 Efforts in discovering new and effective neurotherapeutics are made daily, although most fail to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous solubility, limited permeability through biological membranes ...
Sara Meirinho +4 more
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Clinical Evaluation over Intranasal Administration of Acepromazine and Diazepam in Pigeons (Columba livia domestica) [PDF]
Iranian Journal of Veterinary Surgery, 2023 Safe and effective sedation methods are as much momentous for small birds as for other animals not only for surgical procedures but also for safe handling and diagnostic and clinical procedures such as radiography, wound dressing, blood collection, and ...
Nasser Vajdi, Shohreh Alian Samakkhah
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Intranasal drug delivery: opportunities and toxicologic challenges during drug development
Drug Delivery and Translational Research, 2021 Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS indications.
Lea-Adriana Keller +2 more
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Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
Science, 2022 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent transmission.
Tianyang Mao +10 more
semanticscholar +1 more source
Animals, 2021 The world is currently facing an ongoing coronavirus disease 2019 (COVID-19) pandemic. The disease is a highly contagious respiratory disease which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Salleh Annas, Mohd Zamri-Saad
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Intranasal delivery of BDNF-loaded small extracellular vesicles for cerebral ischemia therapy.
Journal of Controlled Release, 2023 Mesenchymal stem cells (MSCs) have shown promise for the therapy of cerebral ischemia in animal studies and clinical trials, yet their clinical application still faces many challenges.
Xin Zhou +10 more
semanticscholar +1 more source
Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System
Pharmaceutics, 2022 Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies.
Tyler P. Crowe, Walter H. Hsu
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Translational Considerations in the Development of Intranasal Treatments for Epilepsy
Pharmaceutics, 2023 Epilepsy is a common and serious neurological disorder, to which a high proportion of patients continue to be considered “drug-resistant”, despite the availability of a host of anti-seizure drugs.
Richard N. Prentice, Shakila B. Rizwan
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