Results 11 to 20 of about 140,818 (295)

Intranasal COVID-19 vaccines: From bench to bed

EBioMedicine, 2022
Summary Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization. However, vaccination today failed to prevent the virus infection through the upper respiratory tract, which is partially due to the absence of mucosal ...
Aqu Alu, Li Chen, H. Lei, Yuquan Wei, Xiaohe Tian, Xiawei Wei   +5 more
semanticscholar   +1 more source

Intranasal Polymeric and Lipid-Based Nanocarriers for CNS Drug Delivery

Pharmaceutics, 2023
Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases.
R. Maher, Almudena Moreno-Borrallo, D. Jindal, Binh T. Mai, E. Ruiz‐Hernández, A. Harkin   +5 more
semanticscholar   +1 more source

Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

bioRxiv, 2023
Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission.
Gabriela Baldeon Vaca, M. Meyer, Ana Cadete, C. Hsiao, A. Golding, Albert Jeon, E. Jacquinet, Emily Azcue, Chenxia Guan, Xavier Sanchez-Felix, Colette Pietzsch, C. Mire, Matthew A. Hyde, Margaret E. Comeaux, Julie M. Williams, Jean C. Sung, A. Carfi, D. Edwards, A. Bukreyev, Kapil Bahl   +19 more
semanticscholar   +1 more source

A Physiologically Based Pharmacokinetic Model for Predicting Diazepam Pharmacokinetics after Intravenous, Oral, Intranasal, and Rectal Applications

Pharmaceutics, 2021
Diazepam is one of the most prescribed anxiolytic and anticonvulsant that is administered through intravenous (IV), oral, intramuscular, intranasal, and rectal routes.
Sundus Khalid, Muhammad Fawad Rasool, Imran Imran, Abdul Majeed, Hamid Saeed, Anees ur Rehman, Waseem Ashraf, Tanveer Ahmad, Yousef A. Bin Jardan, Faleh Alqahtani   +9 more
doaj   +1 more source

Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies

Acta Pharmaceutica Sinica B, 2021
The management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the use of
C. Costa, J. Moreira, J. S. Sousa Lobo, A. C. Silva   +3 more
semanticscholar   +1 more source

Novel Targets and Interventions for Cognitive Complications of Diabetes

Frontiers in Physiology, 2022
Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia, often coexist in individuals over 65 years of age. Vascular contributions to cognitive impairment/dementia (VCID) are the second leading cause of dementias under the ...
Victoria Wolf, Victoria Wolf, Yasir Abdul, Yasir Abdul, Adviye Ergul, Adviye Ergul   +5 more
doaj   +1 more source

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

Science Translational Medicine, 2021
Intranasal vaccination of hamsters and rhesus macaques with ChAdOx1 nCoV-19 reduces shedding of SARS-CoV-2 after challenge. Intranasal SARS-CoV-2 vaccination Protection conferred by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines ...
Neeltje van Doremalen, Jyothi N. Purushotham, Jonathan E. Schulz, M. Holbrook, T. Bushmaker, A. Carmody, J. Port, C. Yinda, A. Okumura, G. Saturday, F. Amanat, F. Krammer, P. Hanley, Brian J. Smith, J. Lovaglio, S. Anzick, Kent D. Barbian, C. Martens, S. Gilbert, T. Lambe, V. Munster   +20 more
semanticscholar   +1 more source

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

Cell, 2020
The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a prefusion stabilized spike protein (ChAd-SARS-CoV-2-S)
Ahmed O. Hassan, Natasha M. Kafai, I. Dmitriev, J. Fox, Brittany K. Smith, Ian B Harvey, Rita E. Chen, Emma S. Winkler, Alex W. Wessel, J. Case, E. Kashentseva, B. McCune, Adam Leitman Bailey, Haiyan Zhao, L. VanBlargan, Ya-Nan Dai, Meisheng Ma, L. Adams, S. Shrihari, Jonathan E. Danis, Lisa E. Gralinski, Yixuan J. Hou, A. Schäfer, A. S. Kim, Shamus P. Keeler, D. Weiskopf, R. Baric, M. Holtzman, D. Fremont, D. Curiel, M. Diamond   +30 more
semanticscholar   +1 more source

Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.

New England Journal of Medicine, 2021
BACKGROUND Experimental studies and small clinical trials have suggested that treatment with intranasal oxytocin may reduce social impairment in persons with autism spectrum disorder.
L. Sikich, A. Kolevzon, B. King, C. McDougle, Kevin Sanders, Soo-Jeong Kim, Marina Spanos, Tara Chandrasekhar, M. P. Trelles, Carol M Rockhill, Michelle L Palumbo, Allyson Witters Cundiff, Alicia K. Montgomery, P. Siper, M. Minjarez, L. Nowinski, Sarah Marler, Lauren C. Shuffrey, Cheryl Alderman, Jordana Weissman, Brooke Zappone, Jennifer E. Mullett, Hope Crosson, Natalie Hong, Stephen K Siecinski, Stephanie N. Giamberardino, Sheng Luo, Lilin She, M. Bhapkar, Russell Dean, A. Scheer, Jacqueline L Johnson, S. Gregory, J. Veenstra-VanderWeele   +33 more
semanticscholar   +1 more source

Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA

Science immunology, 2021
Description A heterogeneous population of cells secreting mucosal IgA confers protection against influenza virus infection. Flu defense via lung-resident IgA+ memory B cells Secretory IgA antibody is known to be a key effector molecule in establishing ...
Ji-Eun Oh, E. Song, Miyu Moriyama, P. Wong, Sophia Zhang, Ruoyi Jiang, Shirin Strohmeier, S. Kleinstein, F. Krammer, A. Iwasaki   +9 more
semanticscholar   +1 more source