Results 21 to 30 of about 140,818 (295)

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

open access: yesEpilepsy & Behavior Reports, 2022
Nasal administration of treatments for neurologic conditions, including rescue therapies to treat seizure clusters among people with epilepsy, represents a meaningful advance in patient care.
Steve S. Chung   +5 more
semanticscholar   +1 more source

Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs

open access: yesPharmaceutics, 2022
Intranasal administration is a promising route for brain drug delivery. However, it can be difficult to formulate drugs that have low water solubility into high strength intranasal solutions.
Patrícia C. Pires   +3 more
doaj   +1 more source

Using intranasal corticosteroids [PDF]

open access: yesCanadian Medical Association Journal, 2021
About 5% of Canadians are affected by sinonasal inflammation.[1][1] There is broad expert consensus supporting the effectiveness of intranasal corticosteroids for treating allergic and nonallergic rhinitis, acute rhinosinusitis and chronic rhinosinusitis with and without nasal polyposis.[2][2],[3 ...
Fowler, James, Sowerby, Leigh J
openaire   +2 more sources

Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity

open access: yesScience Translational Medicine, 2022
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization strategies are needed that elicit protection at mucosal portals of pathogen entry.
B. Hartwell   +23 more
semanticscholar   +1 more source

A comparative study of the effect of intranasal dexamethasone and normal saline on the occurrence of nausea and vomiting after hysterectomy: a clinical trial study [PDF]

open access: yesمجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. Many studies have been performed to prevent nausea and vomiting after surgery with different drugs alone or in combination, but no definite answer has been given yet.
Hamidreza Shetabi   +2 more
doaj   +1 more source

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

open access: yesScience, 2021
Halting transmission The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein binds to host cells and initiates membrane fusion and cell infection.
R. D. de Vries   +18 more
semanticscholar   +1 more source

Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders

open access: yesPharmaceutics, 2022
Intranasal administration has gained an increasing interest for brain drug delivery since it allows direct transport through neuronal pathways, which can be quite advantageous for central nervous system disorders, such as depression and anxiety ...
Margarida Alberto   +3 more
doaj   +1 more source

COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges

open access: yesHuman Vaccines & Immunotherapeutics, 2022
Multiple vaccines have recently been developed, and almost all the countries are presently vaccinating their population to tackle the COVID-19 pandemic.
K. Dhama   +8 more
semanticscholar   +1 more source

Nano-Encapsulated Melatonin: A Promising Mucosal Adjuvant in Intranasal Immunization against Chronic Experimental T. gondii Infection

open access: yesTropical Medicine and Infectious Disease, 2022
Melatonin (MLT) is now emerging as one of the universally accepted immunostimulators with broad applications in medicine. It is a biological manipulator of the immune system, including mucosal ones. MLT was encapsulated in solid lipid nanoparticles (SLNs)
Doaa E. Said   +5 more
doaj   +1 more source

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial.

open access: yesJAMA Neurology, 2020
Importance Insulin modulates aspects of brain function relevant to Alzheimer disease and can be delivered to the brain using intranasal devices. To date, the use of intranasal insulin to treat persons with mild cognitive impairment and Alzheimer's ...
S. Craft   +11 more
semanticscholar   +1 more source

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