Results 11 to 20 of about 2,191,985 (278)

Intranasal administration

Drug Delivery System, 2020
Naoto Suzuki, Takanori Kanazawa, Toyofumi Suzuki, Noriyasu Kamei   +3 more
openaire   +2 more sources

Efficacy of intranasal naloxone compared to other administration routes in prehospital opioid overdose management and beyond: a narrative review

Emergency Care Journal
Drug-related deaths in Italy, especially from opioid overdoses, increased by 6% among individuals aged 15-34 from 2014 to 2018. Opioid-related deaths rose by 6.6% in the 15-24 age group and by 5.4% in the 25-34 age group during this period.
Luigi Venuso, Francesco Ricciardi, Antonio Del Prete, Michele Virgolesi, Gianluca Pucciarelli, Luigi Langella, Teresa Rea   +6 more
doaj   +3 more sources

Safety, Efficacy and Bio-Distribution Analysis of Exosomes Derived From Human Umbilical Cord Mesenchymal Stem Cells for Effective Treatment of Bronchopulmonary Dysplasia by Intranasal Administration in Mice Model [PDF]

International Journal of Nanomedicine
Wanting Xu,1– 3 Xiaolin Jieda,1– 3 Yue Wu,1– 3 Fengling Du,1– 3 Lu Ma,1– 3 Lijuan Luo,1– 3 Dong Liu,1– 3 Ling Guo,3 Jing Liu,3 Wenbin Dong1– 3 1Division of Neonatology, Department of Pediatrics, the Affiliated Hospital of Southwest Medical University ...
Xu W, Jieda X, Wu Y, Du F, Ma L, Luo L, Liu D, Guo L, Liu J, Dong W   +9 more
doaj   +2 more sources

Intranasal creatine administration increases brain creatine level and improves Barnes maze performance in rats

Brain Research Bulletin, 2023
While skeletal muscle creatine levels can be enhanced by exogenous creatine supplementation, the elevation of brain creatine levels with oral creatine administration remains a challenge due to a lack of effective transportation of creatine through the ...
Kaiqing Chen, Xiaoping Hu
doaj   +1 more source

Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice

Pharmaceutics, 2023
Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is ...
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge   +6 more
doaj   +1 more source

Synthesis of an insulin-loaded mucoadhesive nanoparticle designed for intranasal administration: focus on new diffusion media

Frontiers in Pharmacology, 2023
Intranasal administration is a drug delivery approach to provide a non-invasive pharmacological response in the central nervous system with relatively small peripheral side effects. To improve the residence time of intranasal drug delivery systems in the
Tahereh Jamshidnejad-Tosaramandani, S. Kashanian, Isaac Karimi, H. Schiöth   +3 more
semanticscholar   +1 more source

Intranasal administration of stem cell-derived exosomes for central nervous system diseases

Neural Regeneration Research, 2023
Exosomes, lipid bilayer-enclosed small cellular vesicles, are actively secreted by various cells and play crucial roles in intercellular communication. These nanosized vesicles transport internalized proteins, mRNA, miRNA, and other bioactive molecules ...
Shuho Gotoh, M. Kawabori, Miki Fujimura
semanticscholar   +1 more source

Intranasal administration of collagenase develops cerebral microbleeds and vascular dementia in mice: In vivo pilot study

Brain Hemorrhages, 2023
Objective: To establish a new animal model of lobar cerebral microbleeds (CMBs), we examined whether intranasal administration of collagenase induced CMBs in young mice which did not have hypertensive pathologic features. Methods: We used thirty-two male
Kenyu Hayashi, Prativa Sherchan, John H. Zhang, Yu Hasegawa   +3 more
doaj   +1 more source

Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action

Pharmaceutics, 2022
Acute and chronic administration of intranasal oxytocin and vasopressin have been extensively utilized in both animal models and human preclinical and clinical studies over the last few decades to modulate various aspects of social cognition and their ...
S. Yao, K. Kendrick
semanticscholar   +1 more source

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

Signal Transduction and Targeted Therapy, 2022
The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain or increase the immune responses owing to ...
H. Lei, Aqu Alu, Jingyun Yang, Wen-hui Ren, Cai He, Tianxia Lan, Xuemei He, Li Yang, Jiong Li, Zhenling Wang, Xiangrong Song, Wei Wang, G. Lu, Xiawei Wei   +13 more
semanticscholar   +1 more source