Results 11 to 20 of about 57,366 (267)

Effect of Administration Route on the Pharmacokinetics of Cobalamin in Elderly Patients: A Randomized Controlled Trial

Current Therapeutic Research, 2014
Background: The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. The injection is painful and inconvenient, particularly for elderly persons.
Monique P.H. Tillemans, PharmD, Eline M.V.J. Donders, MD, Sjoerd L. Verweij, PharmD, Ruud T.M. Van der Hoeven, PharmD, Kees J. Kalisvaart, MD, PhD   +4 more
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Comparative evaluation of two intranasal forms of Curcumin: Quantitation and impact on mouse model of asthma

Phytomedicine Plus, 2023
Aim of the study: Present study aimed to investigate impact of two different intranasal forms of curcumin on mouse model of asthma and detection of its absorption after different time points of administration.
Payal Singh, Ruchi Chawla, Ajai Kumar Pandey, J.K. Mishra, Rashmi Singh   +4 more
doaj   +1 more source

Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers

Pharmaceutics, 2022
Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well as tachyphylaxis and systemic, undesirable side effects
Graciela Cárdenas, Raúl J. Bobes, Gladis Fragoso, Nicolas I. Pérez-Osorio, Marisela Hernández, Alejandro Espinosa, Agnes Fleury, José Flores, The Revival Project Consortium, Juan Pedro Laclette, Edda Sciutto, Helgi Jung-Cook   +11 more
doaj   +1 more source

Rapid and Widespread Distribution of Intranasal Small Extracellular Vesicles Derived from Mesenchymal Stem Cells throughout the Brain Potentially via the Perivascular Pathway

Pharmaceutics, 2023
Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-based drug delivery system to the central nervous system (CNS).
Weiwei Shen, Tongyao You, Wenqing Xu, Yanan Xie, Yingzhe Wang, Mei Cui   +5 more
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Effects of Topical Intranasal Doxycycline Treatment in the Rat Allergic Rhinitis Model [PDF]

Clinical and Experimental Otorhinolaryngology, 2014
ObjectivesAllergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation ...
Mehmet Ozgür Avincsal, Seda Ozbal, Ahmet Omer Ikiz, Cetin Pekcetin, Enis Alpin Güneri   +4 more
doaj   +1 more source

Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications

Pharmaceutics, 2023
Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti, Jesus Vicente de Julián-Ortiz, Ofelia Vila-Busó, Octavio Diez-Sales, Amparo Nácher   +4 more
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Pre-clinical study of protective potency of candidate recombinant live pertussis vaccine for intranasal administration

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
The aim of present research is studying of protective potency of candidate recombinant live pertussis vaccine (RLPV) for intranasal administration.Materials and methods.
L. N. Sinyashina, E. G. Semin, A. Yu. Medkova, R. A. Syundyukova, G. I. Karataev   +4 more
doaj   +1 more source

Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway

Scientific Reports, 2022
The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder ...
Narumi Hashikawa-Hobara, Yoshikazu Yoneyama, Kyoushiro Fujiwara, Naoya Hashikawa   +3 more
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Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals. [PDF]

Medičnì Perspektivi, 2017
The study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m3 and 13.0 mg/m3 of the substance to laboratory animals during their ...
Т. А. Alekhina, V. А. Turkina, О. І. Grushka   +2 more
doaj   +2 more sources

Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms

Drug Design, Development and Therapy, 2022
Jinghui Wang,1 Yuhua Zhang,2 Meifeng Zhang,1 Si Sun,1 Yang Zhong,1 Lei Han,1 Yitong Xu,1 Dong Wan,3 Junhui Zhang,4 Huifeng Zhu1 1College of Pharmaceutical Sciences & College of Chinese Medicine, Southwest University, Chongqing, 400715, People’s Republic ...
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H   +9 more
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