Results 21 to 30 of about 2,191,985 (278)

Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers

Pain Research and Management, 2021
Background. For more than 60 years, the synthetic opioid fentanyl has been widely used in anaesthesia and analgesia. While the intravenous formulation is primarily used for general anaesthesia and intensive care settings, the drug’s high lipophilic ...
S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart   +7 more
doaj   +1 more source

Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients

Pharmaceutics, 2022
As a mental disease in modern society, depression shows an increasing occurrence, with low cure rate and high recurrence rate. It has become the most disabling disease in the world.
Zhiyu Jin, Yu Han, Dan-shen Zhang, Zhongqiu Li, Yongshuai Jing, Beibei Hu, Shiguo Sun   +6 more
semanticscholar   +1 more source

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Pharmaceutics, 2022
Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently ...
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki   +5 more
doaj   +1 more source

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

Vaccines, 2021
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
R. King, A. Silva-Sánchez, Jessica N. Peel, David Botta, A. Dickson, Amelia K. Pinto, S. Meza-Perez, S. Allie, Michael D. Schultz, Mingyong Liu, J. Bradley, S. Qiu, Guang Yang, Fen Zhou, Esther Zumaquero, Thomas S. Simpler, B. Mousseau, J. Killian, B. Dean, Q. Shang, J. Tipper, Christopher A Risley, K. Harrod, Tsungwei Feng, Y. Lee, B. Shiberu, Vyjayanthi Krishnan, I. Peguillet, Jianfeng Zhang, T. Green, T. Randall, J. Suschak, B. Georges, J. Brien, F. Lund, M. Roberts   +35 more
semanticscholar   +1 more source

Intranasal Vaccination With Recombinant Antigen-FLIPr Fusion Protein Alone Induces Long-Lasting Systemic Antibody Responses and Broad T Cell Responses

Frontiers in Immunology, 2021
A simple formulation is urgently needed for mucosal vaccine development. We employed formyl peptide receptor-like 1 inhibitory protein (FLIPr), an FcγR antagonist secreted by Staphylococcus aureus, as a vector to target ovalbumin (OVA) to dendritic cells
Ming-Shu Hsieh, Chia-Wei Hsu, Ling-Ling Tu, Kit Man Chai, Li-Lu Yu, Chiao-Chieh Wu, Mei-Yu Chen, Chen-Yi Chiang, Shih-Jen Liu, Shih-Jen Liu, Shih-Jen Liu, Ching-Len Liao, Hsin-Wei Chen, Hsin-Wei Chen, Hsin-Wei Chen   +14 more
doaj   +1 more source

Intranasal Administration of Drugs [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2008
To investigate how nasally applied substances distribute in the nose depending on the form of application.Observer-blinded study.University hospital research unit.Fifteen healthy volunteers aged 22 to 32 years.Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts.
Mandy, Scheibe, Christopher, Bethge, Martin, Witt, Thomas, Hummel   +3 more
openaire   +2 more sources

Intranasal Administration of a TRAIL Neutralizing Monoclonal Antibody Adsorbed in PLGA Nanoparticles and NLC Nanosystems: An In Vivo Study on a Mouse Model of Alzheimer’s Disease

Biomedicines, 2022
Alzheimer’s disease (AD) is a neurodegenerative disorder that progressively compromises cognitive functions. Tumor necrosis factor (TNF)-Related Apoptosis Inducing Ligand (TRAIL), a proinflammatory cytokine belonging to the TNF superfamily, appears to be
T. Musumeci, Giulia Di Benedetto, C. Carbone, A. Bonaccorso, G. Amato, M. J. Lo Faro, Chiara Burgaletto, G. Puglisi, R. Bernardini, G. Cantarella   +9 more
semanticscholar   +1 more source

Intranasal administration of acetylcholinesterase inhibitors [PDF]

BMC Neuroscience, 2008
This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the development of a therapeutically viable formulation. In vivo testing confirmed achievement of therapeutically relevant drug levels that matched or exceeded those for oral ...
Costantino, Henry R, Leonard, Alexis, Brandt, Gordon, Johnson, Paul H, Quay, Steven C   +4 more
openaire   +2 more sources

Intranasal Administration of RBD Nanoparticles Confers Induction of Mucosal and Systemic Immunity against SARS-CoV-2

Vaccines, 2021
Mucosal immunity plays a significant role in host defense against viruses in the respiratory tract. Because the upper respiratory airway is a primary site of SARS-CoV-2 entry, immunization at the mucosa via the intranasal route could potentially lead to ...
Tuksin Jearanaiwitayakul, Mathurin Seesen, R. Chawengkirttikul, Jitra Limthongkul, Suttikarn Apichirapokey, S. Sapsutthipas, S. Phumiamorn, P. Sunintaboon, S. Ubol   +8 more
semanticscholar   +1 more source

Intranasal administration of regulatory dendritic cells is useful for the induction of nasal mucosal tolerance in a mice model of allergic rhinitis

World Allergy Organization Journal, 2020
Background: Intranasally administered dendritic cells (DCs) migrate into blood and thymus to induce immune responses. Regulatory dendritic cells (DCs) are also useful agents for allergy control.
Motohiko Suzuki, Makoto Yokota, Yoshihiro Kanemitsu, Wei-Ping Min, Shinya Ozaki, Yoshihisa Nakamura   +5 more
doaj   +1 more source