Results 21 to 30 of about 57,366 (267)
Marketing research on intranasal medicines of domestic market
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 Modern development of biopharmaceutical research in world science and practice promotes the use of new dosage forms or administration routes of active substances in the human body.
B. S. Burlaka +2 more
doaj +1 more source
Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
doaj +1 more source
Electrocardiogram Assessment in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Anesthetics [PDF]
Iranian Journal of Veterinary Surgery, 2017 Objective- The objective of the present study was to define electrocardiographic data following intranasal administration of diazepam, midazolam and xylazine with or without Ketamine in Chough.Design- To determine the heart effects of anesthetics in ...
Majid Taati, Abbas Raisi
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Bioavailability of dexmedetomidine after intranasal administration
European Journal of Clinical Pharmacology, 2011 The aim of this proof-of-concept study was to characterize the pharmacokinetics and pharmacodynamics of intranasal dexmedetomidine compared with its intravenous administration in a small number of healthy volunteers.Single doses of 84 μg of dexmedetomidine were given once intravenously and once intranasally to seven healthy men.
Iirola, Timo +6 more
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Intranasal Administration for Pain: Oxytocin and Other Polypeptides [PDF]
Pharmaceutics, 2021 Pain, particularly chronic pain, remains one of the most debilitating and difficult-to-treat conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with plastic changes in the peripheral and central nervous systems.
Vimala N. Bharadwaj +4 more
openaire +3 more sources
Pharmaceutics, 2022 The histamine-1 receptor antagonist azelastine was recently found to impact SARS-CoV-2 viral kinetics in a Phase 2 clinical trial (CARVIN). Thus, we investigated the relationship between intranasal azelastine administrations and viral load, as well as ...
Christiane Dings +8 more
doaj +1 more source
The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling
SAGE Open Medicine, 2018 Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol.
Isabelle Cooper +3 more
doaj +1 more source
Development and evaluation of vinpocetine inclusion complex for brain targeting
Asian Journal of Pharmaceutical Sciences, 2015 The objective of this paper is to prepare vinpocetine (VIN) inclusion complex and evaluate its brain targeting effect after intranasal administration. In the present study, VIN inclusion complex was prepared in order to increase its solubility. Stability
Jiaojiao Ding, Jinfeng Li, Shirui Mao
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Frontiers in Pharmacology, 2022 Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey +4 more
doaj +1 more source
PLoS ONE, 2015 The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have ...
Katie Daughters +5 more
doaj +1 more source