Results 31 to 40 of about 2,191,985 (278)

Intranasal administration of mitochondria improves spatial memory in olfactory bulbectomized mice

Experimental biology and medicine, 2021
Here, we found that functionally active mitochondria isolated from the brain of NMRI donor mice and administrated intranasally to recipient mice penetrated the brain structures in a dose-dependent manner.
N. Bobkova, D. Zhdanova, N. Belosludtseva, N. Penkov, G. Mironova   +4 more
semanticscholar   +1 more source

Intranasal Administration of Codium fragile Polysaccharide Elicits Anti-Cancer Immunity against Lewis Lung Carcinoma

International Journal of Molecular Sciences, 2021
Natural polysaccharides have shown promising effects on the regulation of immunity in animals. In this study, we examined the immune stimulatory effect of intranasally administered Codium fragile polysaccharides (CFPs) in mice.
Yuhua Wang, Eun-Koung An, So-jung Kim, S. You, Jun-O Jin   +4 more
semanticscholar   +1 more source

Effects of multiple-dose intranasal oxytocin administration on social responsiveness in children with autism: a randomized, placebo-controlled trial

Molecular Autism, 2023
Background Intranasal administration of oxytocin is increasingly explored as a new approach to facilitate social development and reduce disability associated with a diagnosis of autism spectrum disorder (ASD).
N. Daniels, M. Moerkerke, J. Steyaert, A. Bamps, E. Debbaut, J. Prinsen, Tiffany Tang, S. Van der Donck, B. Boets, K. Alaerts   +9 more
semanticscholar   +1 more source

Effect of Administration Route on the Pharmacokinetics of Cobalamin in Elderly Patients: A Randomized Controlled Trial

Current Therapeutic Research, 2014
Background: The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. The injection is painful and inconvenient, particularly for elderly persons.
Monique P.H. Tillemans, PharmD, Eline M.V.J. Donders, MD, Sjoerd L. Verweij, PharmD, Ruud T.M. Van der Hoeven, PharmD, Kees J. Kalisvaart, MD, PhD   +4 more
doaj   +1 more source

Comparative evaluation of two intranasal forms of Curcumin: Quantitation and impact on mouse model of asthma

Phytomedicine Plus, 2023
Aim of the study: Present study aimed to investigate impact of two different intranasal forms of curcumin on mouse model of asthma and detection of its absorption after different time points of administration.
Payal Singh, Ruchi Chawla, Ajai Kumar Pandey, J.K. Mishra, Rashmi Singh   +4 more
doaj   +1 more source

A Compensatory Liability Regime to Promote the Exchange of Microbial Genetic Resources for Research and Benefit Sharing [PDF]

, 2011
Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules ...
Andersen, Hanne, Buonaguro, Franco M., Buonaguro, Luigi, Hinkula, Jorma, Lewis, Mark, Pal, Ranajit, Schroeder, Ulf, Tagliamonte, Maria, Torneselloa, Maria Lina, Visciano, Maria Luisa, Wahren, Britta   +10 more
core   +2 more sources

Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers

Pharmaceutics, 2022
Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well as tachyphylaxis and systemic, undesirable side effects
Graciela Cárdenas, Raúl J. Bobes, Gladis Fragoso, Nicolas I. Pérez-Osorio, Marisela Hernández, Alejandro Espinosa, Agnes Fleury, José Flores, The Revival Project Consortium, Juan Pedro Laclette, Edda Sciutto, Helgi Jung-Cook   +11 more
doaj   +1 more source

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]

, 2003
The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Couet, William, Dufès, Christine, Gaillard, Afsaneh, Gaillard, Frédéric, Muller, Jean-Marc, Olivier, Jean-Christophe   +5 more
core   +3 more sources

Rapid and Widespread Distribution of Intranasal Small Extracellular Vesicles Derived from Mesenchymal Stem Cells throughout the Brain Potentially via the Perivascular Pathway

Pharmaceutics, 2023
Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-based drug delivery system to the central nervous system (CNS).
Weiwei Shen, Tongyao You, Wenqing Xu, Yanan Xie, Yingzhe Wang, Mei Cui   +5 more
doaj   +1 more source

Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]

, 2012
Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Danish Ahmed, Shivangi Jaiswal, Shruti Mishra, Sweta Kumari   +3 more
core   +2 more sources