Results 91 to 100 of about 32,558 (212)

Disentangling the effect of brain insulin resistance on brain health (BIR‐BrainHealth): Rationale and study protocol

Diabetic Medicine, EarlyView.
Abstract Aims Insulin signalling in the brain is crucial for systemic metabolic regulation and cognitive function. In some individuals, these effects are reduced, a phenomenon referred to as brain insulin resistance (BIR). This condition may contribute to the elevated risk of cognitive decline and dementia in diabetes, yet its prevalence, mechanisms ...
Sabrina Wangler, Peter Sørensen, Konni Kass, Nicole Jaqueline Jensen, Mark Bitsch Vestergaard, Julia Hummel, Ronja Völk, Julie Christine Antvorskov, Flemming Pociot, Jørgen Rungby, Martin Heni, Henrik Bo Wiberg Larsson   +11 more
wiley   +1 more source

Intranasal delivery of iron chelators and management of central nervous system disease. [PDF]

Front Pharmacol
Cheng R, Kim J.
europepmc   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Intranasal delivery of rotigotine to the brain for treating Parkinson's disease. [PDF]

Fundam Res
Kou D, Xu K, Yin J, Wang N, Zhang R, Zeng J, Gao M.   +6 more
europepmc   +1 more source

Local Delivery of a Bio‐Engineered IL‐37 Fc‐Fusion Ameliorates Experimental Allergic Asthma in Mice

Allergy, EarlyView.
Lars P. Lunding, Marcel F. Nold, Claudia A. Nold‐Petry, Michael Wegmann   +3 more
wiley   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Polyplex of peptide-mannan and RNA for intranasal delivery of TGF-β siRNA in treatment of pulmonary fibrosis. [PDF]

Bioact Mater
Feng B, Singh A, Yang Y, Phan P, Xu H, Zhu Y, Huang J, Sastry V, Zhao Z, Hu YS, Cheng G, Malik AB, Liu Y.   +12 more
europepmc   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease. [PDF]

Mater Today Bio
Zhang Y, Yin C, Tian Y, Li X, Wang H, Han S, Chen H, Hou H.   +7 more
europepmc   +1 more source

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Journal of Child Psychology and Psychiatry, EarlyView.
Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female ratio narrowing to approximately 1:1.
Anka Bernhard, Christine M. Freitag, Kerstin Konrad, Lucres Jansen, Andreas G. Chiocchetti, Christina Stadler, Stephane A. De Brito, Graeme Fairchild, Gregor Kohls   +8 more
wiley   +1 more source