Results 81 to 90 of about 32,558 (212)

Clarifying the Distinction Between Inclining Moral Bioenhancement and Prohibitory Moral Bioenhancement, and Their Effects on Freedom

Bioethics, EarlyView.
ABSTRACT The project of Moral Bioenhancement (MBE)—biomedical interventions causing individuals to have better moral beliefs, motivations, or behaviours—is controversial, particularly as MBE relates to human freedom. Proponents argue that MBE is utility‐promoting and compatible with freedom.
Daniel Lee
wiley   +1 more source

Correction: Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer's disease. [PDF]

Alzheimers Res Ther
Abdulhameed N, Babin A, Hansen K, Weaver R, Banks WA, Talbot K, Rhea EM.   +6 more
europepmc   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Intranasal delivery of a polymeric nanoparticle subunit vaccine for the induction of protective immunity against respiratory syncytial virus. [PDF]

Front Immunol
Ostrowski SM, Hartmeier PR, Lipp MA, Perkins T, Reed E, Li X, Meng WS, Empey KM.   +7 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Potential of intranasal delivery of human mesenchymal stem cells and extracellular vesicles for stroke therapy. [PDF]

Acta Biomater
Arbabian A, Driscoll T, Li Y, Grant SC.
europepmc   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Intranasal Delivery of Curcumin-Loaded Pure Drug Self-Assembled Lipid-Based Nanoparticles for Targeted Therapy of Depression. [PDF]

Int J Nanomedicine
Chen T, Liu X, Li D, Cheng Z, Zheng X, Yu Z.   +5 more
europepmc   +1 more source

A Cross‐Sectional Study of Patient Views on Acceptability of Olfactory Implants

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives Unlike other chronic conditions, effective therapies for smell and taste disorders (SATDs) remain scarce. Olfactory implants are an emerging area of therapy aimed at restoring the sense of smell through electrical stimulation of the olfactory pathway.
Gabija Klyvyte, William Ansley, Mehmet Ergisi, Lois Camp, Prajakta Choudari, Natalia Glibbery, Mohammed Jawad, Tharsika Myuran, Duncan Boak, Carl Philpott   +9 more
wiley   +1 more source

Multi-functionalized chitosan-Extracellular vesicles nanohybrid system for intranasal delivery of pApoE2 to attenuate age-related inflammation. [PDF]

Int J Biol Macromol
Gothwal A, Muolokwu CE, Belin MAF, Tagoe BNA, Frey WH, Zhao J, Parsons TM, Kanekiyo T, Singh J.   +8 more
europepmc   +1 more source