Results 111 to 120 of about 57,259 (320)

Intranasal BCG vaccination induces systemic and pulmonary mucosal immune responses against tuberculosis in a goat model

Frontiers in Immunology
Early immune containment of mycobacteria at the infection site is key to tuberculosis (TB) vaccine development. Intranasal delivery strategies offer a promising alternative to parenteral BCG vaccination, particularly for pulmonary TB, the predominant ...
Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Sergio López-Soria, Sergio López-Soria, Enric Vidal, Enric Vidal, Mariano Domingo, Mariano Domingo, Bernat Pérez de Val, Bernat Pérez de Val   +18 more
doaj   +1 more source

Intranasal scopolamine preparation and method [PDF]

A new method and preparation for intranasal delivery of scopolamine provides a safe and effective treatment for motion sickness and other conditions requiring anticholinergic therapy. The preparation can be in the form of aqueous nasal drops, mist spray,
Cintron, Nitza M., Putcha, Lakshmi
core   +1 more source

Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. [PDF]

, 2019
We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear.
Ardito, Taylor, Hwangbo, Cheol, Kim, So-Jin, Lee, Patty J, Li, Alfred, Min, Jin-Na, Peng, Tien, Sauler, Maor, Shan, Peiying, Zhang, Xuchen, Zhang, Yi   +10 more
core   +1 more source

RBD‐SD1 Nanoparticle Vaccines From DPP4‐Using Merbecoviruses Elicit a Cross‐Reactive Antibody Response but Limited Cross‐Protective Immunity

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles displaying RBD‐SD1 from MERS‐CoV, NL140422, and HKU4 elicited robust and cross‐reactive IgG responses in mice. Only MERS‐CoV RBD‐SD1 induced neutralizing antibodies against MERS‐CoV and protected human DPP4 mice from a MERS‐CoV challenge, indicating conserved serologic but limited cross‐neutralizing epitopes.
Peter J. Halfmann, Jeong Soo Lee, Tong Wang, Augustine Duffy, Janie E. Rogers, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +9 more
wiley   +1 more source

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. [PDF]

, 2009
The innate immune response of airway epithelial cells to airborne allergens initiates the development of T cell responses that are central to allergic inflammation.
Angkasekwinai, Pornpimon, Barranco, Wade T, Corry, David B, Dong, Chen, Goswami, Sangeeta, Greenlee, Kendra J, Kheradmand, Farrah, Polikepahad, Sumanth, Redding, David, Seryshev, Alexander, Shan, Ming, Singh, Bhupinder, Song, Li-zhen, Sur, Sanjiv, Woodruff, Prescott   +14 more
core  

Intranasal Treatment of Central Nervous System Dysfunction in Humans [PDF]

, 2012
One of the most challenging problems facing modern medicine is how to deliver a given drug to a specific target at the exclusion of other regions. For example, a variety of compounds have beneficial effects within the central nervous system (CNS), but ...
Christian Benedict, Colin D. Chapman, Helgi B. Schiöth, Lusine Danielyan, Manfred Hallschmid, Suzanne Craft, William H. Frey   +6 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Data describing IFNγ-mediated viral clearance in an adult mouse model of respiratory syncytial virus (RSV)

Data in Brief, 2017
The data presented here are related to the research article entitled “Age predicts cytokine kinetics and innate immune cell activation following intranasal delivery of IFNγ and GM-CSF in a mouse model of RSV infection” (Eichinger et al., 2017) [1].
Katherine M. Eichinger, Kerry M. Empey
doaj   +1 more source

Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8+ T Cells That Are Protective against Influenza Virus Infection [PDF]

, 2020
James G. Bedford, Irina Caminschi, Linda M. Wakim   +2 more
openalex   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source