Results 111 to 120 of about 32,558 (212)

No Effect of Preoperative Mepolizumab on Early Postoperative Healing After ESS for Severe CRSwNP

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 6, December 2026.
ABSTRACT Objective To evaluate postoperative endoscopic mucosal healing 2 weeks after ESS in patients with severe CRSwNP treated with surgery alone versus surgery combined with biologics initiated 2 weeks preoperatively. Methods In this exploratory post hoc analysis, patients with severe CRSwNP were divided into two cohorts: ESS alone and ESS with ...
A. S. Homøe, M. Høxbro, J. Tidemandsen, V. Backer, E. Kiaer, S. Scott, N. Rubek, K. Aanæs   +7 more
wiley   +1 more source

Relief and Prevention of Post-Traumatic Headache Using Intranasal Delivery of Lidocaine for Youth (RAPPIDLY): A Feasibility Study. [PDF]

Neurotrauma Rep
Griffiths V, Tsampalieros A, Cortel-LeBlanc A, Cortel-LeBlanc M, Greenough M, Webster RJ, Lamontagne C, Meckler G, Poonai N, Orr SL, Dodd AB, Zemek R, TRANSCENDENT Concussion Research Program.   +12 more
europepmc   +1 more source

Application and Research Progress of Nucleic Acid‐Based Drug Delivery Systems in the Treatment of Intracerebral Hemorrhage

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
This review summarizes recent advances in NADDS for treating ICH, highlighting the advantages and applications of key delivery technologies including lipid nanoparticles, exosomes, and DNA nanostructures. ABSTRACT Intracerebral hemorrhage (ICH) is a devastating stroke subtype associated with high mortality and neurological disability, yet effective ...
Jingyan Wang, Xuejiao Zeng, Pengyu Niu, Jinjin Shi, Wenyan Yu   +4 more
wiley   +1 more source

Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza infection models. [PDF]

NPJ Vaccines
Hatton CF, Briggs E, Polychronakis E, Vats A, Sharma B, Wongborphid S, Cayol T, Sedaghat-Rostami E, Manoharan S, Guan A, Moorhouse EJ, MacLoughlin R, Rijal P, Townsend AR, Salguero FJ, Pauydal B, Tchilian E.   +16 more
europepmc   +1 more source

Efficacy and safety of ketamine for post‐traumatic stress disorder: A systematic review with narrative synthesis and consideration of military and veteran populations

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Post‐traumatic stress disorder (PTSD) is a debilitating disorder with limited pharmaceutical treatment options. Ketamine, a noncompetitive N‐methyl‐d‐aspartate (NMDA) receptor antagonist with rapid‐onset effects, has emerged as a potential treatment, particularly for patients who do not respond to first‐line therapies.
Mary Ivasyutyn, Saajan Bhakta
wiley   +1 more source

Intranasal delivery of rapamycin via brain-targeting polymeric micelles for Alzheimer's disease treatment. [PDF]

Int J Pharm
Sugandhi VV, Gattu K, Mundrathi V, Khairnar R, Arshad T, Kumar S, Cho H.   +6 more
europepmc   +1 more source

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV—Important Lessons Learned

Journal of Medical Primatology, Volume 55, Issue 6, December 2026.
ABSTRACT Background In a randomized, blinded, dual center study across two European primate research facilities, we evaluated the immunogenicity and protective efficacy of a DNA prime—oropharyngeal adenoviral boost vaccination strategy against respiratory syncytial virus (RSV).
Matthias Tenbusch, Gerrit Koopman, Petra Mooij, Berit Roshani, Pascal Irrgang, Dennis Lapuente, Ivanela Kondova, Willy M. Bogers, Edmond J. Remarque, Ramona Vestweber, Samuel Alberto Merida Ruiz, Nadine Krüger, Sebastian Meyer, Olaf Gefeller, Christiane Stahl‐Hennig, Klaus Überla   +15 more
wiley   +1 more source

Intranasal Delivery of Ivermectin Nanosystems as an Antitumor Agent: Focusing on Glioma Suppression. [PDF]

ACS Biomater Sci Eng
Velho MC, Winck VL, Mariot CDS, Scholl JN, Weber AF, Souza RK, Visioli F, Figueiró F, Deon M, Pilger DA, Beck RCR.   +10 more
europepmc   +1 more source

Opioid Use and Family Members' Experiences of Opioids in Paediatric Cancer Pain Management: An Integrative Review

Scandinavian Journal of Caring Sciences, Volume 40, Issue 4, December 2026.
ABSTRACT Aim To analyse the use of opioids in children with cancer and the experiences of their family members regarding opioids used in pain management to improve family nursing. Design An integrative review. Methods A systematic literature search was carried out in four databases (CINAHL, MEDLINE, PsycInfo and Scopus) in August 2023, and was ...
Noora Puusa, Eeva Harju, Maija‐Liisa Kalliomäki, Elina Haavisto   +3 more
wiley   +1 more source