Results 131 to 140 of about 32,558 (212)

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3914-3925, November 2026.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Intranasal delivery systems for traumatic brain injury: Advancements and perspectives. [PDF]

J Tissue Eng
Yoo SH, Heo SC, Bae JS, Lee JH, Knowles JC, Kim HW.   +5 more
europepmc   +1 more source

Development, Optimization, and Physicochemical Characterization of Fluorescent Carbon Dot‐Ginkgo biloba Extract Co‐Loaded Niosomes for Future Neurological Disease‐Relevant Evaluation

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Carbon dot–Ginkgo biloba–loaded niosomal nanovesicles are fabricated via rotary evaporation, probe sonication, and centrifugation to co‐deliver natural neuroprotective agents to the brain. The optimized system shows high encapsulation, sustained release, and excellent biocompatibility, suggesting a promising nano‐vesicular platform for Alzheimer's ...
Yasaman Mohammadi, Mohammad Saied Salehi, Ehsan Heidari, Mina Ebrahimi, Nahid Ashjazadeh   +4 more
wiley   +1 more source

Intranasal delivery of LB244-loaded M2 microglia membrane nanoparticles for targeted treatment of neuroinflammation after I/R brain injury. [PDF]

Mater Today Bio
Zhang X, Guo J, Zhang Y, Zhao S, Chen J, Jiang J, Hu X, Zhou B, Zhang K.   +8 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling to Assess Transporter‐Mediated Drug–Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1402-1413, November 2026.
Zavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Alice Ke, Ernesto Callegari, Manthena V.S. Varma, Mayur K Ladumor, Chieko Muto, Richard J. Bertz, Hannah M. Jones, Vaishali Sahasrabudhe, Jing Liu   +8 more
wiley   +1 more source

Formulation and characterization of Mirtazapine loaded mucoadhesive cubosomal in-situ gel for intranasal delivery. [PDF]

Ther Deliv
Thakkar HP, Unagar A, Goinawala D, Panchal R.   +3 more
europepmc   +1 more source

Intranuclear localisation of KLF3‐AS1 under the balance of histone acetylation and methylation in BMSCs ameliorates cerebral ischaemia‒reperfusion injury by preserving microglial mitochondrial function and inhibiting inflammatory polarisation

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Epigenetic activation of KLF3‐AS1 in BMSCs, characterised by increased H3K27 acetylation and decreased H3K27 trimethylation at its promoter, enhances BMSC viability, proliferation and migration. Exosomal KLF3‐AS1 is delivered to microglia, which mechanistically promotes ETV4 nuclear translocation to activate SIRT3 transcription, preserving microglial ...
Qian Li, Xiaowei Xie, Jie Chen, Yu Cao, Dingzhou Zhou   +4 more
wiley   +1 more source

Deconvolution of cargo delivery and immunogenicity following intranasal delivery of mRNA lipid nanoparticle vaccines. [PDF]

Mol Ther Nucleic Acids
Vu MN, Pilapitiya D, Kelly A, Koutsakos M, Kent SJ, Juno JA, Tan HX, Wheatley AK.   +7 more
europepmc   +1 more source

Antidepressant Misuse in Esports: A Review of Pharmacology, Adverse Effects, Pharmacokinetics and Biomatrix‐Based Detection for Anti‐Doping Applications

Drug Testing and Analysis, Volume 18, Issue 11, Page 1361-1373, November 2026.
This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum, Shao‐Hsin Hung, Meng‐Tsang Hsieh, Mei‐Chich Hsu, William Chih‐Wei Chang   +4 more
wiley   +1 more source

Intranasal delivery of hypoxia-preconditioned extracellular vesicles derived from BMSCs alleviates neuroinflammation and brain dysfunction in TBI. [PDF]

Stem Cell Res Ther
Chen L, Yang Y, Chen J, Lin Y, Xian L, Chen Y, Zhu X, Tang Y, Zuo Y, Xia S, Xia X, Xu Y, Wang S.   +12 more
europepmc   +1 more source