Results 151 to 160 of about 31,838 (257)

Intranasal delivery of LB244-loaded M2 microglia membrane nanoparticles for targeted treatment of neuroinflammation after I/R brain injury. [PDF]

Mater Today Bio
Zhang X, Guo J, Zhang Y, Zhao S, Chen J, Jiang J, Hu X, Zhou B, Zhang K.   +8 more
europepmc   +1 more source

Multi‐omics reveals a novel Cxcr4+ subpopulation of alveolar macrophages and therapeutic effect of AMD3100 in mice with advanced silicosis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
The progression of silicosis‐associated fibrosis relies on a positive feedback loop mediated by crosstalk between Cxcr4+ macrophages and Cxcl12+ fibroblasts and the therapeutic potential of targeting the Cxcl12/Cxcr4 axis with AMD3100 as a novel strategy for treating silicosis.
Min Mu, Bing Li, Hangbing Cao, Yuanjie Zou, Ruiqing Yan, Fei Wang, Yehong Zhao, Zihao Xie, Miaomiao Du, Xiaolong Wu, Xinrong Tao, Jianhua Wang   +11 more
wiley   +1 more source

Butyrylated Starch Attenuates Antibiotic‐Exacerbated Allergic Rhinitis by Restoring the Gut Microbiota and Barrier Function in Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Vancomycin‐induced gut dysbiosis depletes butyrate‐producing bacteria, reduces colonic butyrate, disrupts the intestinal barrier, and exacerbates allergic rhinitis (AR). The colon‐targeted butyrate precursor butyrylated starch reverses this pathological cascade, restores immune homeostasis, and alleviates AR, providing a novel dietary intervention for ...
Yuxi Lin, Qingqing Xu, Siyi Tang, Jingmin Chen, Xing Lin, Yang Liu, Yuanteng Xu   +6 more
wiley   +1 more source

Intranasal delivery of hypoxia-preconditioned extracellular vesicles derived from BMSCs alleviates neuroinflammation and brain dysfunction in TBI. [PDF]

Stem Cell Res Ther
Chen L, Yang Y, Chen J, Lin Y, Xian L, Chen Y, Zhu X, Tang Y, Zuo Y, Xia S, Xia X, Xu Y, Wang S.   +12 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Formulation and characterization of Mirtazapine loaded mucoadhesive cubosomal in-situ gel for intranasal delivery. [PDF]

Ther Deliv
Thakkar HP, Unagar A, Goinawala D, Panchal R.   +3 more
europepmc   +1 more source

Pharmacy‐Based Immunization Delivery: A Comprehensive History and Current Challenges

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 6, June 2026.
ABSTRACT Pharmacists and their teams have a long history of involvement with vaccines. This paper describes the contributions of pharmacy‐based immunization delivery in the United States from the 1800's to date. Early activities centered around storage and distribution of antitoxins and vaccines. From the 1950s through the early 1990s, pharmacists were
Jean‐Venable R. Goode, Mitchel C. Rothholz, Stephan L. Foster, Erica R. Brody, John D. Gräbenstein   +4 more
wiley   +1 more source

Deconvolution of cargo delivery and immunogenicity following intranasal delivery of mRNA lipid nanoparticle vaccines. [PDF]

Mol Ther Nucleic Acids
Vu MN, Pilapitiya D, Kelly A, Koutsakos M, Kent SJ, Juno JA, Tan HX, Wheatley AK.   +7 more
europepmc   +1 more source

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen, Weishi Liu, Min Guo, Tongyao You, Yingzhe Wang, Tiansiyu Wen, Suzhen Liang, Xiaodi Xie, Yanfeng Jiang, Qiang Dong, Jin‐Tai Yu, Mei Cui   +11 more
wiley   +1 more source

Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer's Disease. [PDF]

Int J Nanomedicine
Sun C, Sha S, Shan Y, Gao X, Li L, Xing C, Guo Z, Du H.   +7 more
europepmc   +1 more source