Results 171 to 180 of about 31,838 (257)

Novel intranasal delivery of sihosogansan demonstrates rapid antidepressant activity via GABAergic and BDNF/TrkB pathways: identification of potential bioactive quality markers. [PDF]

Chin Med
Tran KN, Munni YA, Nguyen LTH, Oh TW, Choi HJ, Moon IS, Yang IJ.   +6 more
europepmc   +1 more source

Efficacy and Safety of Dexmedetomidine‐Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, Volume 36, Issue 6, Page 617-627, June 2026.
ABSTRACT Background Emergence delirium (ED) is a common complication in pediatric anesthesia. Although intranasal dexmedetomidine (DEX) is widely used, its application is constrained by a slow onset, residual risk of ED in some patients, and risks such as bradycardia and hypotension.
Munder Lateiresh, Alhasan Altayf, Ayham Qatza, Abubaker Alghazal, Hasan Al‐sakkaf, Muhammed Elhadi   +5 more
wiley   +1 more source

Intranasal delivery of DPSC-derived small extracellular vesicles-encased phloroglucinol attenuates non-motor and motor deficits and promotes neurogenesis in an in vivo rat model of Parkinson's disease. [PDF]

Stem Cell Res Ther
Mondal K, Ghanty R, Mahadevan A, Waghmare G, Santhoshkumar R, Bn N, Datta I.   +6 more
europepmc   +1 more source

Investigating Strategies to Enhance the Aqueous Solubility of Ketamine HCl for Intranasal Delivery. [PDF]

Pharmaceutics
Idoudi S, Saleh A, Akkbik M, Amine L, Alansari K, Rachid O, Alkilany AM.   +6 more
europepmc   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, Volume 40, Issue 6, Page 3354-3368, June 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific Immunity. [PDF]

ACS Nano
Park J, Pho T, Bhatnagar N, Mai LD, Rodriguez-Otero MR, Pal SS, Le CTT, Jenison SE, Li C, May GA, Arioka M, Kang SM, Champion JA.   +12 more
europepmc   +1 more source

Acute‐Phase Interventions After Self‐Harm for Preventing Suicide and Recurrence: A Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica, Volume 153, Issue 6, Page 610-626, June 2026.
ABSTRACT Introduction Suicide risk is markedly elevated following presentation after self‐harm, yet the evidence base for interventions initiated in the immediate post‐presentation period has not been synthesized with specific attention to this high‐risk window. Clarifying which early interventions may reduce adverse outcomes is essential for informing
Guilherme Pimenta Roncete, Luis C. Farhat, Loren Beiram, Bianca Besteti Fernandes Damiano, Craig J. Bryan, Karina L. Ramirez, Euripedes Constantino Miguel, Rodolfo Furlan Damiano   +7 more
wiley   +1 more source

Intranasal delivery of blackberry-loaded Chitosan nanoparticles for antipsychotic potential in Ketamine-induced schizophrenia in rats. [PDF]

Sci Rep
George MY, Farag N, Menze ET, Elezaby RS, Salem NA, Elrahmany SK, Adel N, ElKhatib RM, Galal M, Assem H, Elkhouly R, Wesa MA, Hesham N, Hossam N, Ayoub IM.   +14 more
europepmc   +1 more source

Five‐Grass‐Pollen Sublingual Immunotherapy Drops Are Efficacious and Well Tolerated in Adults: The RHAPSODY Phase III Trial

Allergy, Volume 81, Issue 6, Page 2123-2132, June 2026.
The RHAPSODY multinational study investigated 26 months of continuous treatment with 5‐grass‐pollen sublingual SLIT drops in adults with moderate‐to‐severe grass‐pollen‐induced allergic rhinoconjunctivitis. The primary efficacy endpoint (the average daily total combined score) showed statistically significant differences in favour of the active ...
Alain Didier, Ruta Gronskyte Juhl, Terrie Dalgaard, Antoine Chartier, Philippe Devillier   +4 more
wiley   +1 more source

Engineered MSC-EVs loaded with BDNF-enhancing neuropeptides via a non-disruptive method enhance post-stroke neuroregeneration via intranasal delivery. [PDF]

J Nanobiotechnology
Kim JE, Ji YE, Hwang HJ, Go GE, Lim HJ, Yoo J, Kim J, Park D, Kim EH, Kim D, Bang OY.   +10 more
europepmc   +1 more source