Results 191 to 200 of about 31,838 (257)

Pediatric NIH Workshop: Session III—Specialties and Complexities of Juvenile NHP Models for HIV Prevention Research

Journal of Medical Primatology, Volume 55, Issue 3, June 2026.
ABSTRACT Nonhuman primates (NHPs) have emerged as an indispensable model for studying HIV pathogenesis, vaccines, and therapies. The development of chimeric Simian/Human immunodeficiency viruses (SHIVs) has been constructed by inserting HIV‐1 Env into the SIV (usually SIVmac239) backbone, and these have proved essential for evaluating HIV neutralizing ...
A. J. Hessell, M.‐C. Gauduin, F. Villinger   +2 more
wiley   +1 more source

Anti-Inflammatory Combination of Puerarin and Ac2-26 Using Intranasal Delivery for Effective Against Ischemic Stroke in Rat Model. [PDF]

Int J Nanomedicine
Xu G, Ma C, Chu H, Hu W, Yang L, Li S.
europepmc   +1 more source

From Trials to Clinics: Considerations for Implementing Psychedelic‐Assisted Therapy Into Clinical Practice

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Jessie Kim, Liam Lochhead, Cory R. Weissman   +2 more
wiley   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Intranasal delivery of AEP inhibitor-loaded neuron-targeted liposome ameliorates radiation-induced brain injury. [PDF]

Mater Today Bio
Liao K, Gao Y, Cheng M, Zhang Y, Zhao J, Zhou L, Wu R, Cai G, Cao L, Chen J, Lin Y.   +10 more
europepmc   +1 more source

Health inequities in pediatric anaphylaxis: A policy framework and call to action for equitable care from SIAIP allergy prevention commission

Pediatric Allergy and Immunology, Volume 37, Issue 6, June 2026.
Abstract Pediatric anaphylaxis is a rapidly evolving and potentially fatal allergic reaction whose incidence is increasing worldwide, particularly among young children. Despite international guidelines identifying intramuscular epinephrine as the first‐line, life‐saving treatment, significant health inequities persist in the prevention, recognition ...
Carolina Grella, Angela Klain, Amelia Licari, Sara Manti, Francesca Mori, Francesca Galletta, Antonio Andrea Senatore, Leonardo Tomei, Michele Miraglia del Giudice, Gian Luigi Marseglia, Cristiana Indolfi, The SIAIP Primary and Secondary Prevention of Allergic Diseases Commission   +11 more
wiley   +1 more source

Intranasal Delivery of Medications for the Treatment of Neurologic Conditions: A Pharmacology Update. [PDF]

J Neurosci Nurs
Shafer PO, Dean P, Brooks L, Gidal B, Misra SN, Carrazana E.   +5 more
europepmc   +1 more source

Estrogen receptor β regulates sex‐dependent airway mechanics and inflammation in a murine model of allergen exposure

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Sex differences in asthma severity have been reported; however, the specific contribution of estrogen receptor β (ERβ) remains incompletely defined. We tested the hypothesis that ERβ modulates sex‐specific physiological responses to chronic allergen exposure using C57BL/6J wild‐type (WT) and ERβ‐deficient (Esr2−/−) male and female mice ...
Carolyn Damilola Ekpruke, Dustin Rousselle, Maksat Babayev, Omar Borges‐Sosa, Rachel Alford, Lyidia Dinwiddie, David Michael Merritt, Christopher Michael Hemmerich, Douglas B. Rusch, Sarah Bradley, Matthew Louis Retzner, Erik Parker, Patricia Silveyra   +12 more
wiley   +1 more source

Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice. [PDF]

J Neuroimmune Pharmacol
Bhuiyan P, Zhang W, Liang G, Jiang B, Vera R, Chae R, Kim K, Louis LS, Wang Y, Liu J, Chuang DM, Wei H.   +11 more
europepmc   +1 more source

Design, Synthesis, and Evaluation of Coumarin‐Rasagiline Hybrids as Multifunctional Neuroprotective Agents

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Novel coumarin‐rasagiline hybrid molecules were designed and synthesized as multifunctional agents targeting key pathological mechanisms of neurodegenerative diseases. These compounds exhibited hMAO‐B inhibitory activity, antioxidant and neuroprotective effects, supported by ADMET profiling and molecular modeling studies. The design of hybrid molecules
Aitor Carneiro, Sandra Barreiro, Claudia Sofia Machado, Miguel Pinto, Daniel Chavarria, Manuel Novás, Davide Crucitti, Carlos Fernandes, Maria João Matos   +8 more
wiley   +1 more source