Results 211 to 220 of about 31,838 (257)
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Intranasal delivery of tenoxicam in rat
International Journal of Pharmaceutics, 2001Intranasal delivery of tenoxicam was studied in male rats on single dose administration of 0.36 mg/rat and compared with intravenous administration. Tenoxicam plasma levels were determined by RP-HPLC method with UV detection that employed piroxicam as an electroactive internal standard in the analysis.
C V, Raghavan, V D, Abimon
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Biomaterials for intranasal and inhaled vaccine delivery
Nature Reviews Bioengineering, 2023Delivery of vaccines by nasal sprays may enable more robust, protective mucosal immune responses against infectious diseases, such as COVID-19, compared with intramuscular injection. In this Comment, we highlight how biomaterials can be designed to allow intranasal and inhaled vaccination.
Devorah Cahn +3 more
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Intranasal Delivery of Nicardipine in the Rat
Journal of Pharmaceutical Sciences, 1986The intranasal absorption of nicardipine hydrochloride was characterized in an in vivo rat model system in which the normal mechanisms of mucociliary clearance and drainage of an instilled dose were not physically altered. The results obtained in this manner, therefore, are expected to be predicative of the delivery and absorption dynamics exhibited in
G C, Visor, E, Bajka, E, Benjamin
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Intranasal Delivery of Neuropeptides
2011A major barrier to entry of neuropeptides into the brain is low bioavailability and presence of the blood-brain barrier. Intranasal delivery of neuropeptides provides a potentially promising alternative to other routes of administration, since a direct pathway exists between the olfactory neuroepithelium and the brain. Use of the rat as an animal model
Michael C, Veronesi +2 more
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Intranasal Delivery of Nanoparticle-Based Vaccines
Therapeutic Delivery, 2017Most pathogens gain access to the human body and initiate systemic infections through mucosal sites. A large number of currently marketed licensed vaccines are parenterally administered; they generate strong systemic immunity but not mucosal immunity.
Marasini, Nirmal +2 more
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Intranasal drug delivery for treatment of Alzheimer’s disease
Drug Delivery and Translational Research, 2021The Alzheimer's disease is a neurodegenerative condition with severe consequences interfering with patient quality of life. It is characterized as a progressive and irreversible brain disorder hampering memory and thinking, affecting the capacity to perform daily tasks leading to physical and cognitive incapacitation.
Fonseca, Leonor Cancela +6 more
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Clinical Research and Regulatory Affairs, 1993
AbstractThe intranasal administration of drugs is a promising alternative to parenteral administration. The nasal route represents an interesting alternative for drugs which have low oral bioavailability because of degradation in GI tract or extensive mucosal or first-pass metabolism.
H. Zia, P. Dondeti, T. E. Needham
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AbstractThe intranasal administration of drugs is a promising alternative to parenteral administration. The nasal route represents an interesting alternative for drugs which have low oral bioavailability because of degradation in GI tract or extensive mucosal or first-pass metabolism.
H. Zia, P. Dondeti, T. E. Needham
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Advanced Drug Delivery Reviews, 1998
In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Although this route is currently being marketed for the systemic administration of several drugs, it has only recently been studied.
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In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Although this route is currently being marketed for the systemic administration of several drugs, it has only recently been studied.
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Intranasal Drug Delivery for Brain Targeting
Current Drug Delivery, 2005Many drugs are not being effectively and efficiently delivered using conventional drug delivery approach to brain or central nervous system (CNS) due to its complexity. The brain and the central nervous system both have limited accessibility to blood compartment due to a number of barriers.
Tushar K, Vyas +3 more
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Advanced formulations for intranasal delivery of biologics
International Journal of Pharmaceutics, 2018The global biologics market has been ever increasing over the last decades and is predicted to top Euro 350 by 2020. Facing this scenario, the parenteral route of biologics administration as hitherto standard route is inconvenient for the future. Among the alternatives, the intranasal delivery of therapeutic biologicals seems to be most promising but ...
Julia, Rohrer +2 more
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