Results 221 to 230 of about 31,838 (257)

Intranasal delivery of vaccines against HIV

Expert Opinion on Drug Delivery, 2006
HIV poses a serious health threat in the world. Mucosal transmission of HIV through the genitourinary tract may be the most important route of transmission. Intranasal immunisations induce vaginal and systemic immune responses. Various protein-, DNA- and RNA-based immunopotentiating adjuvants/delivery systems and live bacterial and viral vectors are ...
Michael, Vajdy, Manmohan, Singh
openaire   +2 more sources

Intranasal delivery of stem cells to the brain

Expert Opinion on Drug Delivery, 2011
Stem cell-based therapy has proved to be a promising treatment option for neurological disorders. However, there are difficulties in successfully administrating these stem cells. For example, the brain-blood barrier impedes the entrance of stem cells into the CNS after systemic administration.
Yongjun, Jiang, Juehua, Zhu, Gelin, Xu, Xinfeng, Liu   +3 more
openaire   +2 more sources

Nanotechnologies for intranasal drug delivery: an update of literature

Pharmaceutical Development and Technology, 2021
Scientific research has focused its attention on finding an alternative route to systemic oral and parenteral administration, to overcome their usual drawbacks, such as hepatic first-pass which decreases drug bioavailability after oral administration, off-target effects, low patient compliance and low speed of onset of the pharmacological action in ...
Lombardo R., Musumeci T., Carbone C., Pignatello R.   +3 more
openaire   +2 more sources

Preparation and evaluation of fexofenadine microemulsions for intranasal delivery

International Journal of Pharmaceutics, 2010
To enhance the solubility and bioavailability of poorly absorbable fexofenadine, microemulsion system composed of oil, surfactant and co-surfactant was developed for intranasal delivery. Phase behavior, particle size, viscosity and solubilization capacity of the microemulsion system were characterized. Histopathology and in vivo nasal absorption of the
Hong-Mei, Piao, Prabagar, Balakrishnan, Hyun-Jong, Cho, Hyunjun, Kim, You-Sun, Kim, Suk-Jae, Chung, Chang-Koo, Shim, Dae-Duk, Kim   +7 more
openaire   +3 more sources

Lipid Nanoparticles for Nasal/Intranasal Drug Delivery

Critical Reviews™ in Therapeutic Drug Carrier Systems, 2017
Studies on the development of drug delivery systems have increased because these systems have particular characteristics that allow them to improve therapeutics. Among these, lipid nanoparticles (solid lipid nanoparticles, SLNs; and nanostructured lipid carriers, NLCs) have demonstrated suitability for drug targeting.
Cunha, S., Amaral, M. H., Lobo, J. M. Sousa, Silva, Ana Catarina   +3 more
openaire   +3 more sources

Intranasal Delivery of Nanoparticles

Nanomedicine, 2022
Ralf P Friedrich, Iwona Cicha, Rainer Tietze, Harald Unterweger, Stefan Lyer, Christina Janko, Christoph Alexiou   +6 more
openaire   +2 more sources

Intranasal delivery of drugs to eustachian tube orifice

The Journal of Laryngology & Otology, 2011
AbstractBackground:Intranasal medication administration which aims to deliver to the eustachian tube orifice has been adopted for the management of a number of otological conditions, acting via a reduction in tubal oedema and improved ventilation. Evidence for the optimal head position for such drug administration is limited. We compared four different
Y G, Karagama, M, Rashid, J L, Lancaster, A, Karkanevatos, R S, William   +4 more
openaire   +2 more sources

Mechanism of intranasal drug delivery directly to the brain

Life Sciences, 2018
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier.
Tyler P, Crowe, M Heather West, Greenlee, Anumantha G, Kanthasamy, Walter H, Hsu   +3 more
openaire   +2 more sources

DISTRIBUTION OF ANTIHISTAMINES INTO THE CSF FOLLOWING INTRANASAL DELIVERY

Biopharmaceutics & Drug Disposition, 1997
The preferential absorption of certain drug compounds from the nasal cavity into the cerebrospinal fluid (CSF) raises questions regarding the transport processes controlling drug disposition following intranasal delivery. The disposition characteristics of several structurally similar antihistamine compounds, hydroxyzine, chlorpheniramine, triprolidine,
K J, Chou, M D, Donovan
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Intranasal Drug Delivery to the Brain

2013
Drug delivery into the central nervous system (CNS) compartment is often restricted by the blood–brain barrier (BBB) and blood–cerebrospinal fluid barriers (BCSFB) that separate the blood from brain interstitial and cerebrospinal fluids, respectively.
Jeffrey J. Lochhead, Robert G. Thorne
openaire   +1 more source