Results 161 to 170 of about 31,838 (257)

Intranasal delivery of engineered anti-SARS-CoV-2 extracellular vesicles therapeutically represses lung infection and inflammation. [PDF]

Drug Deliv Transl Res
Idris A, Idris A, Shrivastava S, Gao W, Supramaniam A, Tayyar Y, West NP, Kelly G, Acharya D, McMillan NAJ, Morris KV.   +10 more
europepmc   +1 more source

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host–pathogen interactions, and immune modulation.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
wiley   +1 more source

Barriers to Care for Obstructive Sleep Apnea: Primary Care Perspectives at a Safety Net Hospital

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
ABSTRACT Objective Given the prevalence of obstructive sleep apnea (OSA) and sparsity of sleep medicine specialists, OSA management often depends on primary care providers (PCPs). We investigate PCP experiences managing OSA within a community health network (CHN) serving underserved patients.
Michelle Florentine, Arushi Gulati, Ruben Hernandez, Jolie L. Chang, Megan L. Durr   +4 more
wiley   +1 more source

Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung disease. [PDF]

NPJ Vaccines
Higham SL, Wang Z, Murugaiah V, Song J, Thomas C, Zhang H, Griesenbach U, Alton EWFW, Granger LA, Esparza AF, Barbieri BD, Hitchen PG, Kellam P, Shattock RJ, Sriskandan S, Reece ST, Tregoning JS.   +16 more
europepmc   +1 more source

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

Intranasal delivery of metformin using metal-organic framework (MOF)-74-Mg nanocarriers. [PDF]

Adv Compos Hybrid Mater
Yuan M, Han Z, Somayaji Y, Nguyen N, Hu H, Madhu LN, Attaluri S, Kodali M, Yang Y, Hsu YC, Ahuja A, Srinivasan R, Pellois JP, Zhou HC, Shetty AK, Wang Y.   +15 more
europepmc   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury. [PDF]

J Nanobiotechnology
Li P, Sun S, Zhu X, Liu X, Yin R, Chen Y, Chang J, Ye L, Gao J, Zhao X, Xu H, Wang Y, Zuo W, Sun Z, Wang S, Zhang X, Wei J, Zhao RC, Han Q.   +18 more
europepmc   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source