Results 161 to 170 of about 57,259 (320)

S1G1-2　Usability evaluation of intranasal drug delivery devices and Ergonomics

, 2019
Mikio MURATA, Masahiro Sumi, Kiyoshi Kubota, Masaho HAYASHI, Kiyomi Sadamoto   +4 more
openalex   +2 more sources

A Case for Anti‐IgE Vaccination

Allergy, EarlyView.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

Biphasic Effects on Allergen‐Specific Type 2 Memory B Cells Over 18 Months Sublingual Immunotherapy for House Dust Mite Allergy

Allergy, EarlyView.
Rapid clinical relief of allergy symptoms during 18 months of sublingual immunotherapy (SLIT) for house dust mite (HDM) is associated with increased serum IgE, IgG2, and IgG4 to Der p 1 and Der p 2. Der p 1 and Der p 2 specific Type 2 memory B cells are expanded at 4 months and 12 months of SLIT, with increased expression of CD29 and IgG4.
Lin Hsin, Simone Reinwald, Anouk von Borstel, Pei Mun Aui, Kirsten Deckert, P. Mark Hogarth, Laurent Mascarell, Mark Hew, Robyn E. O'Hehir, Menno C. van Zelm   +9 more
wiley   +1 more source

Liposome Encapsulated Insulin- a viable option for an intranasal insulin delivery system [PDF]

Saptarshi Roy Choudhury, Bhawya Jha, Poonima Shyam, Anand Thiyagaraj   +3 more
openalex   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Recombinant fowlpox virus vector-based vaccines: expression kinetics, dissemination and safety profile following intranasal delivery

, 2017
David G Townsend, Shubhanshi Trivedi, Ronald J Jackson, Charani Ranasinghe   +3 more
openalex   +1 more source

Intranasal delivery of a synthetic Entamoeba histolytica vaccine containing adjuvant (LecA + GLA-3 M−052 liposomes): In vitro characterization

, 2022
Brynn Murphy, John Z. Chen, Michael Rolo, Mohamed Eldam, Lynn Jordan, Sandra J. Sivananthan, Robert Kinsey, Jeffrey A. Guderian, Karl Pedersen, Mayuresh M. Abhyankar, William A. Petri, Christopher B. Fox, Warren H. Finlay, Reinhard Vehring, Andrew R. Martin   +14 more
openalex   +2 more sources

Synthesis and investigation of a mucoadhesive chitosan derivative for intranasal drug delivery [PDF]

, 2022
T. Kiss, Rita Ambrus, Mohamed M. Abdelghafour, László Janovák, Mária Budai-Szűcs, Ágota Deák, Gábor Katona   +6 more
openalex   +1 more source

An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Nature Communications
Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to
Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C. Moe, Benjamin E. Low, Michael V. Wiles, David Nemazee, Frode L. Jahnsen, John Torgils Vaage, Kenneth A. Howard, Inger Sandlie, Leo C. James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen   +31 more
doaj   +1 more source

Recent trends in drug delivery systems: intranasal drug delivery.

Indian journal of experimental biology, 1999
Nasal route of drug delivery is commonly known for treatment of local ailments like-cold, cough, rhinitis etc. Recently, efforts have been made to deliver various drugs, specially peptides and proteins, through nasal route for systemic use; utilizing the principles and concepts of rate controlled drug delivery and various polymers and absorption ...
V, Agarwal, B, Mishra
openaire   +1 more source