Results 141 to 150 of about 57,277 (349)

Intranasal Drug Delivery Technology in the Treatment of Central Nervous System Diseases: Challenges, Advances, and Future Research Directions

Pharmaceutics
As population aging becomes an increasingly critical global issue, the incidence of central nervous system (CNS) diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke, has risen sharply. However, the blood–brain barrier (BBB)
Xunxun Wu, Ranqing Zang, Yiting Qiu, Yufang Zhang, Junbin Peng, Zhiyun Cheng, Site Wei, Meiyan Liu, Yong Diao   +8 more
doaj   +1 more source

Intranasal co-delivery of IL-6 gene enhances the immunogenicity of anti-caries DNA vaccine [PDF]

, 2014
Lingkai Su, Fei Yu, Zhaofei Li, Zeng Chang, Qingan Xu, Mingwen Fan   +5 more
openalex   +1 more source

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

Small, EarlyView.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins, Louise Bondeelle, Arnaud Charles‐Antoine Zwygart, Thais Melquiades de Lima, Juliano de Paula Souza, Han Kang Tee, Fernando Chahud, Eurico de Arruda Neto, Francesco Stellacci, Renata Fonseca Vianna Lopez, Caroline Tapparel   +10 more
wiley   +1 more source

Editorial: Intranasal Drug Delivery: Challenges and Opportunities [PDF]

Frontiers in Pharmacology, 2022
Ana Fortuna, Ana Fortuna, Katharina Schindowski, Fabio Sonvico, Fabio Sonvico   +4 more
openaire   +5 more sources

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

Small, EarlyView.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad, Shunping Han, Rifka Utami, Rafal Baker, Dina Helal, Zhuoni Li, Mark Tricklebank, Yannis Paloyelis, Julie Wang, Marija M. Petrinovic, Sukhi Bansal, Khuloud T. Al‐Jamal   +11 more
wiley   +1 more source

Illicit Drug‐Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology

The Chemical Record, EarlyView.
This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim, Solpa Lee, Anmo J. Kim, Cong Wang, Yongwoo Jang   +4 more
wiley   +1 more source

Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs [PDF]

, 2018
Santosh Dhakal, Sankar Renu, Shristi Ghimire, Yashavanth Shaan Lakshmanappa, Bradley T. Hogshead, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Harm HogenEsch, Steven Krakowka, Chang Won Lee, Gourapura J. Renukaradhya   +10 more
openalex   +1 more source

Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study [PDF]

, 2020
Inbar Schlachet, Hen Moshe Halamish, Alejandro Sosnik   +2 more
openalex   +1 more source

Intranasal drug delivery: a novel approach [PDF]

Indian Journal of Otolaryngology and Head & Neck Surgery, 2009
Yashpal, Chugh, Pragati, Kapoor, A K, Kapoor   +2 more
openaire   +2 more sources

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

VIEW, EarlyView.
Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley   +1 more source