Results 171 to 180 of about 57,277 (349)

Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties

Journal of Translational Medicine
Targeting drugs to the mitochondrial level shows great promise for acute and chronic treatment of traumatic brain injury (TBI) in both military and civilian sectors.
Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Starlyn L. Okada-Rising, Zachary S. Bailey, Anke H. Scultetus, Deborah A. Shear   +6 more
doaj   +1 more source

Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms

Allergy, EarlyView.
ABSTRACT Background Atopic diseases—including atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), and asthma—are the most common chronic conditions in childhood and adolescence, affecting up to 30% of the global population. In Germany alone, more than 2.1 million children and adolescents are affected.
E. Hamelmann, B. Schaub, K. Beyer, K. Blümchen, M. Gerstlauer, M. V. Kopp, L. Lange, S. Lau, N. Maison, H. Ott, S. M. Schmidt, T. Spindler, C. Traidl‐Hoffmann, C. Vogelberg   +13 more
wiley   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Intranasal Delivery of Inactivated Influenza Virus and Poly(I:C) Adsorbed Corn-Based Nanoparticle Vaccine Elicited Robust Antigen-Specific Cell-Mediated Immune Responses in Maternal Antibody Positive Nursery Pigs

, 2020
Veerupaxagouda Patil, Sankar Renu, Ninoshkaly Feliciano-Ruiz, Yi Han, A. Ramesh, Jennifer Schrock, Santosh Dhakal, Harm HogenEsch, Gourapura J. Renukaradhya   +8 more
openalex   +1 more source

Single‐dose Pasteurella multocida and Histophilus somni autogenous vaccines administered at induction significantly improved feedlot cattle performance and profitability in Australia

Australian Veterinary Journal, EarlyView.
Background Bovine respiratory disease (BRD) is the most economically important disease affecting feedlot cattle. While viral pathogens are initiating agents, bacterial coinfections exacerbate disease severity. Vaccines for Pasteurella multocida and Histophilus somni are not commercially available in Australia.
GM Werid, T Batterham, L O'Meara, K Petrovski, WS Pitchford, DJ Trott   +5 more
wiley   +1 more source

Impact of screening programmes for type 1 diabetes in youth: A systematic review and meta‐analysis

Diabetic Medicine, EarlyView.
Abstract Aim To evaluate the impact of anti‐islet antibody (IAb) screening on the general population and first‐degree relatives (FDRs)/high‐risk individuals and evidence‐based follow‐up modalities. Methods We performed this review through systematic searches of PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov and International ...
Roberto Franceschi, Enza Mozzillo, Marco Marigliano, Giulio Maltoni, Ernesto Maddaloni, Rocco Amendolara, Luca Bernardini, Riccardo Bonfanti, Federica Ciambrelli, Francesca Di Candia, Ludovica Fedi, Alessandro Fierro, Dario Iafusco, Antonio Iannilli, Letizia Leonardi, Claudio Maffeis, Evelina Maines, Riccardo Pertile, Claudia Piona, Ivana Rabbone, Carlo Ripoli, Andrea Scozzarella, Valentina Tiberi, Raffaella Buzzetti, Valentino Cherubini   +24 more
wiley   +1 more source

Total Migraine freedom for breath powered intranasal delivery of 22 mg Sumatriptan Powder (Avp-825) Versus 100 mg oral sumatriptan from the compass study of acute treatment of Migraine [PDF]

, 2015
Rashmi Halker, Stewart J. Tepper, Scott Siegert, Christopher J. Wallick   +3 more
openalex   +1 more source

A sensitive LC‐MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery [PDF]

, 2022
Richard N. Prentice, Younus Mohammad, Shakila B. Rizwan   +2 more
openalex   +1 more source

A systematic review of glucocorticoid use in type 1 diabetes: Glycaemic effects and clinical management strategies

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Glucocorticoids (GCs) are widely utilised for the treatment of inflammatory and autoimmune conditions but often precipitate significant hyperglycaemia. People with type 1 diabetes (PWT1D) may be particularly affected due to the challenges of adjusting insulin dosing, for which recommendations remain unclear.
Alexandra Katz, Aidan Shulkin, Asmaa Housni, Amélie Roy‐Fleming, Rémi Rabasa‐Lhoret, Jean‐Francois Yale, Michael A. Tsoukas, Tricia M. Peters, Anne‐Sophie Brazeau   +8 more
wiley   +1 more source

Intranasal delivery of iron chelators and management of central nervous system disease. [PDF]

Front Pharmacol
Cheng R, Kim J.
europepmc   +1 more source