A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]
, 2010 Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Bernadet, Philippe +14 more
core +2 more sources
Intranasal delivery of Thyroid hormones in MCT8 deficiency [PDF]
PLOS ONE, 2020 Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3'-triiodothyronine (T3) and low thyroxine (T4) levels.
Carmen Grijota-Martínez +5 more
openaire +9 more sources
Formulation strategies for nose-to-brain drug delivery in Alzheimer's disease
Health Sciences Review, 2023 Alzheimer's disease (AD) is a neurodegenerative brain disorder that affects memory, thinking, concentration, and judgment, ultimately hindering a person's ability to perform routine daily activities.
Manisha Vohra +3 more
doaj +1 more source
From clinical application to cognitive enhancement: the example of methylphenidate [PDF]
, 2016 Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD).
Busardo', FRANCESCO PAOLO +4 more
core +1 more source
From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders [PDF]
, 2016 Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a wide range of neurotransmitter and neuromodulator activities. Additionally,
Di Bonaventura, Maria Vittoria Micioni +3 more
core +2 more sources
Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases
Frontiers in ImmunologyOutbreaks of emerging and re-emerging infectious diseases have consistently threatened human health. Since vaccinations are a powerful tool for preventing infectious illnesses, developing new vaccines is essential.
Zhihan Zhang +11 more
doaj +1 more source
Bacterial outer membrane vesicles and vaccine applications [PDF]
, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo +10 more
core +2 more sources
Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung [PDF]
, 2017 Cytomegalovirus vectors are promising delivery vehicles for vaccine strategies that aim to elicit effector CD8+ T cells. To determine how the route of immunization affects CD8+ T cell responses in the lungs of mice vaccinated with a murine ...
Graham, B S +5 more
core +5 more sources
Ectopic premolar tooth in the sigmoid notch [PDF]
, 2016 Impaction of a mandibular premolar is relatively uncommon. Ectopic placement is more unusual and there has been no discussion in the literature of an ectopic mandibular premolar in the coronoid process. In this case report, we present an impacted ectopic
Akgul, Hayati Murat +2 more
core +9 more sources
A patient preference study that evaluated fluticasone furoate and mometasone furoate nasal sprays for allergic rhinitis [PDF]
, 2016 Background: Corticosteroid nasal sprays are the mainstay of treatment for allergic rhinitis. These sprays have sensory attributes such as scent and/or odor, taste and aftertaste, and run down the throat and/or the nose, which, when unpleasant, can affect
Bremner, P +6 more
core +2 more sources