Results 71 to 80 of about 57,277 (349)

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]

, 2015
The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco, COVIELLO, Tommasina, DI MEO, Chiara, MATRICARDI, PIETRO, MONTANARI, ELITA   +4 more
core   +1 more source

A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries [PDF]

, 2020
Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche
A Buffo, A Kamezaki, A Torroglosa, AC Newton, AC Rice, AX Wu-Zhang, BT Susarla, C Kilkenny, C Romero-Grimaldi, CP Blobel, DC Lee, DR Marks, E Flores-Giubi, EK Adrian Jr., ES Anton, F Doetsch, F Garcia-Bernal, FH Gage, GJ Francis, HG Kuhn, HT Ghashghaei, I Comte, J Fallon, J Liu, J Wang, JB Cavanagh, JC McGrath, JM Verdi, K Blennow, K Jin, L Avila, LG Rabaneda, LG Rabaneda, M Carrasco, M Dang, M Dang, M Fatt, M Murillo-Carretero, N Geribaldi-Doldan, N Geribaldi-Doldan, ND Zhao, O Gonzalez-Perez, PK Dash, RG Thorne, S Chirumamilla, S Dominguez-Garcia, SW Sunnarborg, V Tropepe, Y Kim   +48 more
core   +1 more source

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management [PDF]

, 2023
Sayali Dighe, Sunil Jog, Munira Momin, Sujata Sawarkar, Abdelwahab Omri   +4 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Intranasal Therapy in Palliative Care

Pharmaceutics
In recent years, the use of the intranasal route has been actively explored as a possible drug delivery method in the palliative patient population. There are reports demonstrating the effectiveness of nasally administered medications that are routinely ...
Anna Ingielewicz, Robert K. Szymczak
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Intranasal drug delivery by spray and drops

Journal of Pharmacy and Pharmacology, 1985
Abstract A solution of 99m Tc-labelled human serum albumin was administered into the nose as a spray and as one or three drops. The patterns of deposition and the rates of clearance in normal subjects were monitored by gamma scintigraphy. The spray was deposited mainly in the atrium, and cleared slowly into the pharynx.
J G, Hardy, S W, Lee, C G, Wilson
openaire   +2 more sources

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Intranasal fentanyl for pain control: current status with a focus on patient considerations

Patient Preference and Adherence, 2011
Eric Prommer, Lisa ThompsonDivision of Hematology/Oncology, Mayo Clinic College of Medicine, Mayo Clinic Hospital, Scottsdale, AZ, USAAbstract: Of several newer delivery systems under development and investigation for the administration of opioids, the ...
Eric Prommer, Lisa Thompson
doaj