Results 71 to 80 of about 49,659 (173)

Novel Imaging-Based Biomarkers for Identifying Carotid Plaque Vulnerability

Biomolecules, 2023
Carotid artery disease has traditionally been assessed based on the degree of luminal narrowing. However, this approach, which solely relies on carotid stenosis, is currently being questioned with regard to modern risk stratification approaches.
Verónica Fernández-Alvarez, Miriam Linares-Sánchez, Carlos Suárez, Fernando López, Orlando Guntinas-Lichius, Antti A. Mäkitie, Patrick J. Bradley, Alfio Ferlito   +7 more
doaj   +1 more source

Dual-probe molecular MRI for the in vivo characterization of atherosclerosis in a mouse model: Simultaneous assessment of plaque inflammation and extracellularmatrix remodeling [PDF]

, 2019
Molecular MRI is a promising in-vivo modality to detect and quantify morphological and molecular vessel-wall changes in atherosclerosis. The combination of different molecular biomarkers may improve the risk stratification of patients.
Adams, Lisa C., Botnar, Rene M., Brangsch, Julia, Hamm, Bernd, Kaufmann, Jan O., Makowski, Marcus R., Onthank, David C., Reimann, Carolin, Robinson, Simon P., Thöne-Reineke, Christa   +9 more
core   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Assessment of Carotid Plaque Stability Using Contrast-Enhanced Ultrasound and Its Correlation With the Expression of CD147 and MMP-9 in the Plaque

Frontiers in Computational Neuroscience, 2021
This study aims to investigate the correlation between the enhancement degree of contrast-enhanced ultrasound (CEUS) and the expression of CD147 and MMP-9 in carotid atherosclerotic plaques in patients with carotid endarterectomy and evaluate the ...
Shanshan Huang, Xinyin Wu, Linlin Zhang, Jianming Wu, Yi He, Manlin Lai, Jiaqi Xu, Zhenzhou Li   +7 more
doaj   +1 more source

Effect of Neoatherosclerosis and Intervention‐Associated Neoatheroma Rupture on Clinical Outcomes in Patients With In‐Stent Restenosis: A Retrospective Study

Health Science Reports, Volume 8, Issue 7, July 2025.
ABSTRACT Background and Aims Treatment of drug‐eluting stents (DES) in‐stent restenosis (ISR) was challenging. Neoatherosclerosis (NA) occurs earlier and more frequently in DES‐ISR. This study aims to analyze the effect of neoatheroma morphology and intervention‐associated neoatheroma intima rupture on intervention strategies and clinical outcomes in ...
Xiao‐Xia Zhang, Qing Chen, Xiao‐Jiang Zhang, Yao‐Dong Ding, Guo‐Zhong Wang, Mao‐Xiao Nie, Yong Zeng   +6 more
wiley   +1 more source

Evolution and rupture of vulnerable plaques: a review of mechanical effects [PDF]

, 2013
Atherosclerosis occurs as a result of the buildup and infiltration of lipid streaks in artery walls, leading to plaques. Understanding the development of atherosclerosis and plaque vulnerability is of critical importance, since plaque rupture can result ...
Assemat, Pauline, Hourigan, Kerry
core   +2 more sources

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

MedComm, Volume 6, Issue 7, July 2025.
Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi, Haipeng Jiang, Yiyuan Yin, Xinyu Zhou, Yiyouyou Shao, Yongsheng Li, Jianhua Rao   +6 more
wiley   +1 more source

Novel treatment from a botanical formulation Si-Miao-Yong-an decoction inhibits vasa vasorum angiogenesis and stabilizes atherosclerosis plaques via the Wnt1/β-catenin signalling pathway

Pharmaceutical Biology, 2023
Context Si-Miao-Yong-An (SMYA) has been widely used for the clinical treatment of atherosclerosis (AS). Yet, its complete mechanism of action is not fully understood.Objective To investigate the mechanism by which SMYA stabilizes AS plaques from the ...
Zhongwen Qi, Zhipeng Yan, Ke Zhu, Yueyao Wang, Yajie Fan, Tingting Li, Junping Zhang   +6 more
doaj   +1 more source

Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis. [PDF]

, 2016
BACKGROUND: Gadolinium enhancement on high-resolution magnetic resonance imaging (MRI) has been proposed as a marker of inflammation and instability in intracranial atherosclerotic plaque.
Al-Dasuqi, Khalid, Baradaran, Hediyeh, Delgado, Diana, Giambrone, Ashley E, Gupta, Ajay, Iadecola, Costantino, Kamel, Hooman, Knight-Greenfield, Ashley, Min, James K, Navi, Babak B, Teng, Zhongzhao, Wright, Drew   +11 more
core   +2 more sources

Carotid Plaque‐Derived Small Extracellular Vesicles Mediate Atherosclerosis and Correlate With Plaque Vulnerability

MedComm, Volume 6, Issue 6, June 2025.
We profiled the differences in miRNA expression of plaque‐derived small extracellular vesicles (psEVs) from stable and vulnerable plaques of patients with asymptomatic carotid artery stenosis (aCAS), and identified five plasma‐derived sEV miRNAs as potential biomarkers for diagnosing plaque vulnerability.
Xin Xu, Taoyuan Lu, Yao Feng, Wenbo Cao, Dianwei Liu, Peng Gao, Yan Ma, Yabing Wang, Bin Yang, Yanfei Chen, Jian Chen, Ran Xu, Xinyu Wang, Lebin Chen, Yuanyuan Ji, Liqun Jiao   +15 more
wiley   +1 more source