Results 121 to 130 of about 158,913 (343)

Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function. [PDF]

, 2018
We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord.
Ghosh, Biswarup, Lepore, Angelo C., Nong, Jia, Trovillion, Victoria A., Urban, Mark W., Wang, Zhicheng, Wright, Megan C., Zhang, Zhiling, Zhong, Yinghui   +8 more
core   +2 more sources

Differential glymphatic dysfunction and memory correlation in temporal lobe epilepsy subtypes

Epilepsia Open, EarlyView.
Abstract Objective This study aims to evaluate the glymphatic system (GS) in different temporal lobe epilepsy (TLE) subtypes using diffusion tensor imaging analysis along the perivascular space (DTI‐ALPS) and to explore its correlation with clinical factors and memory performance.
Ruotong Chen, Hong Li, Pu Miao, Hongyi Ye, Xiao Chen, Yuyu Yang, Jinqi Zhou, Yihe Chen, Yi Ge, Chenmin He, Xiaotong Shao, Zijian Wang, Yuting Gong, Cong Chen, Shan Wang, Lingli Hu, Lingqi Ye, Yao Ding, Shuang Wang, Linglin Yang   +19 more
wiley   +1 more source

Mispositioned Neurokinin-1 Receptor-Expressing Neurons Underlie Heat Hyperalgesia in Disabled-1 Mutant Mice. [PDF]

, 2019
Reelin (Reln) and Disabled-1 (Dab1) participate in the Reln-signaling pathway and when either is deleted, mutant mice have the same spinally mediated behavioral abnormalities, increased sensitivity to noxious heat and a profound loss in mechanical ...
Basbaum, Allan I, Cilluffo, Marianne, Kim, Ashley S, Phelps, Patricia E, Wang, Xidao, Yvone, Griselda M   +5 more
core  

Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]

, 2015
BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong, Lee, Sunhee C, Letendre, Scott, Lo, Yungtai, Suh, Hyeon-Sook   +4 more
core   +2 more sources

Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries [PDF]

, 2016
Aim: The purpose of this study was to investigate the effect of normal synovial fluid (SF) on exposed endogenous tendon-derived cells (TDC) and engrafted mesenchymal stem cells (MSCs) within the tendon extracellular matrix. Methods: Explants from equine
Dudhia, J, Garvican, E R, Salavati, M, Smith, R K W   +3 more
core   +3 more sources

A COMPARISON BETWEEN INTRATHECAL NALBUPHINE AND DEXMEDETOMIDINE AS ADJUVANTS TO HYPERBARIC BUPIVACAINE FOR LOWER LIMB ORTHOPEDIC SURGERIES

, 2023
Geetanjali Singhal, Arun Kumar Saxena, G. Bharadwaj   +2 more
openalex   +1 more source

Increased lumbar puncture success using a paramedian approach: A retrospective cohort study

Journal of Hospital Medicine, EarlyView.
Abstract Background Lumbar puncture (LP) is frequently necessary in hospitalized patients for diagnostic and therapeutic purposes. Traditional landmark identification by palpation of the lumbar spine and pelvis can see significant failure rates. A paramedian approach is an accepted, though less frequently used technique associated with higher success ...
Jacob Wagner, Kiril Dimitrov, Zachary Lauer, Swati Jain, Omar Jibril, Zach Kaltenborn, Aditya Kler, Andrew Olson, Justin Clark, Kyle Rudser, Matthew Yocum   +10 more
wiley   +1 more source

Phase I Trial of Repeated Intrathecal Autologous Bone Marrow‐Derived Mesenchymal Stromal Cells in Amyotrophic Lateral Sclerosis

Stem Cells Translational Medicine, 2015
Stem cell therapy is an emerging alternative therapeutic or disease‐modifying strategy for amyotrophic lateral sclerosis (ALS). The aim of this open‐label phase I clinical trial was to evaluate the safety of two repeated intrathecal injections of ...
Ki-wook Oh, C. Moon, Hyun Young Kim, Sung-Il Oh, Jinseok Park, Jun Ho Lee, In Young Chang, K. Kim, Seunghyun Kim   +8 more
semanticscholar   +1 more source

T2‐Weighted T1 Mapping and Automated Segmentation of CSF: Assessment of Solute Gradients in the Healthy Brain

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Cerebrospinal fluid (CSF) serves as a medium for nutrient delivery and waste clearance. The T1 relaxation rate, R1, can be used to measure the concentration of intrinsic solutes and extrinsic contrast agents. Purpose To implement a method for R1 mapping and segmentation of CSF and to use this method to explore how R1 of CSF relates ...
Tryggve Holck Storås, Sofie Lysholm Lian, Ingrid Mossige, Jørgen Riseth, Siri Fløgstad Svensson, Grethe Løvland, Geir Ringstad, Kent‐André Mardal, Kyrre Eeg Emblem, Kaja Nordengen   +9 more
wiley   +1 more source

Intrathecal dexmedetomidine as adjuvant for spinal anaesthesia for perianal ambulatory surgeries: A randomised double-blind controlled study

Indian Journal of Anaesthesia, 2015
Background and Aim: The newer trend in regional anaesthesia for ambulatory anorectal surgeries advocate use of lower dose of local anaesthetic, providing segmental block with adjuvants such as opioids and α2 agonists to prolong analgesia.
S S Nethra, M Sathesha, Dixit Aanchal, Pradeep A Dongare, S S Harsoor, D Devikarani   +5 more
doaj   +1 more source