Results 111 to 120 of about 76,887 (294)

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

Intrathecal Therapy in Cancer Pain Management [PDF]

, 2006
The lack of knowledge of intrathecal therapy in cancer pain management by nurses and other health care professionals is a common problem that creates poor patient satisfaction and decreased quality of life. Intrathecal pain pumps may be helpful in cancer
Nygaard, Anne
core   +1 more source

Longitudinal serum and CSF cytokine dynamics in NORSE: Associations with immunotherapy exposure

Epilepsia, EarlyView.
Abstract Objective To characterize serum and cerebrospinal fluid (CSF) cytokine dynamics according to immunotherapy exposure in cryptogenic new‐onset refractory status epilepticus (cNORSE). Methods We analyzed cytokine profiles in 94 serum and 42 CSF samples from 29 and 14 patients, respectively, with cNORSE.
Aurélie Hanin, Clémence Marois, Léa Cosme, Quentin Calonge, Zineb Hayatou, Sarah Baer, Anna‐Lena Behr, Simone Beretta, Francesca Bisulli, Serena Broggi, Michael Cardinale, Carlos Castillo‐Pinto, Adam Celier, Thomas Coppens, Anne De Saint Martin, Krista Eschbach, Susana Ferrao Santos, Elizabeth E. Gerard, Teneille Gofton, Margaret T. Gopaul, Karnig Kazazian, Jeroen Kerstens, Humberto L. Moser Filho, Lorenzo Muccioli, Roberto Santalucia, Hannah Stamberger, Eyal Muscal, Lawrence J. Hirsch, Sophie Demeret, Vincent Navarro   +29 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source

Intrathecal pain pump causing delayed acute flaccid paralysis: A case report and review of the literature

Clinical Case Reports
Key Clinical Message Patients with intrathecal catheters for pain medication infusion should be aware of the possible complication of acute flaccid paralysis.
Megan Finneran, Emilio Nardone
doaj   +1 more source

Agreement between invasive and oscillometric blood pressure measurements during controlled haemorrhage in anaesthetised horses

Equine Veterinary Journal, EarlyView.
Abstract Background Defining the reliability of oscillometry (NIBP) for measuring mean arterial pressure (MAP) during normotension and hypovolaemic hypotension could help with cardiovascular monitoring and management in horses anaesthetised in dorsal recumbency.
Colleen Hickey, Alonso Guedes, Jessica Byrne, Eduardo Hatschbach, Brian Walters, Aaron Rendahl, Caitlin Tearney   +6 more
wiley   +1 more source

Correction to "Temperature Dysregulation Following Intrathecal Morphine for Cesarean Delivery Patients-A Scoping Review". [PDF]

Acta Anaesthesiol Scand
Acta Anaesthesiologica Scandinavica, Volume 71, Issue 1, January 2027.
europepmc   +2 more sources

Intrathecal analgesia and palliative care: A case study

, 2010
Intrathecal analgesia is an interventional form of pain relief with definite advantages and multiple complications. Administration of intrathecal analgesia needs a good resource setting and expertise.
GregoryB Crawford, NaveenS Salins, Crawford, G., Salins, N.   +3 more
core   +1 more source

Expert consensus on neuro‐musculoskeletal functional reconstruction for post‐stroke spastic hemiplegia

Ibrain, EarlyView.
This expert consensus proposes a patient‐centered pathway for functional reconstruction after post‐stroke spastic hemiplegia: “patient goal–pathophysiologic component–treatment target–functional reassessment.” Treatment selection and sequencing across motor retraining, brain–computer interfaces, peripheral nerve surgery, and tendon/soft‐tissue ...
Peng Wen, Yihe Wang, Zhongzheng He, Zhizhong Zhu, Chunbing Chen, Kaifeng Wu, Xiaohong Fu, Guoguang Zhao, Liulin Xiong, “Zunyi Brain‐Computer Interface Medical Center” Working Group, Denggui Cheng, Zhaojian Deng, Min Gong, Chong Han, Qijun Jiang, Hang Li, Jianping Li, Shun Li, Yu Li, Minjie Luo, Chiyuan Ma, Yongzhi Shan, Jun Wang, Nana Wang, Qinglan Wang, Ziheng Wang, Zhongying Wei, Guojun Wu, Bo Xiong, Jianguo Xu, Minpeng Xu, Kaihua Yang, Xi Yang, Fan Zhang, Hongtian Zhang, Jing Zhang, Shaofu Zhang, Hongxin Zhao, Min Zhao, Mingjiang Zhu   +39 more
wiley   +1 more source