Results 91 to 100 of about 74,181 (306)
Annals of Neurology, EarlyView.Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato +7 more
wiley +1 more source
Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment
Annals of Neurology, EarlyView.Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring +18 more
wiley +1 more source
Indian Journal of Anaesthesia, 2010 Sixty ASA grade I/II patients scheduled for elective short laparoscopic procedures under spinal anaesthesia were divided into two groups of 30 each. The first group (group C) received 3.5 ml of hyperbaric bupivacaine with 30 mcg of clonidine.
Poonam S Ghodki +2 more
doaj +1 more source
, 1999 Background The rationale of this study was to evaluate intrathecal ropivacaine for ambulatory surgery. Methods: One hundred fifty patients with American Society of Anesthesiologists physical status 1 scheduled for knee arthroscopy were studied.
Lahaye-Goffart, B +6 more
core +1 more source
Annals of Neurology, EarlyView.Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon +5 more
wiley +1 more source
The Configuration of the Perivascular System Transporting Macromolecules in the CNS
Frontiers in Neuroscience, 2019 Large blood vessels entering the CNS are surrounded by perivascular spaces that communicate with the cerebrospinal fluid and, at their termini, with the interstitial space.
Beata Durcanova +12 more
doaj +1 more source
Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain
, 2009 Howard S Smith,1 Timothy R Deer21Albany Medical College, Department of Anesthesiology, Albany, New York, USA; 2The Center for Pain Relief, Clinical Professor, West Virginia, University, Charleston, West Virginia, USAAbstract: Ziconotide is a conopeptide ...
Timothy R Deer, Howard S Smith
core
Intrathecal anesthesia with ketamine
, 2004 <b>Background and Objectives</b>: Intrathecal anesthesia is the method of choice for transurethral prostate resection in the United Kingdom, despite its associated hypotension.
Hawksworth, C., Serpell, M.
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić +4 more
wiley +1 more source
Pakistan Armed Forces Medical Journal, 2018 This is a double blind placebo controlled study of 120 patients conducted in the department of anesthesiology POF’s Hospital Wah Cantt: from October 2002 to April 2003 to evaluate the post operative analgesia and side effects of IT neostigmine, morphine
Muhammad Ishaque +3 more
doaj