Results 71 to 80 of about 76,887 (294)

Efficacy of Single Bolus Epidural Injection of 0.2% Ropivacaine and Morphine versus Intrathecal 0.2% Ropivacaine and Morphine in Patients Undergoing Laparotomy – A Prospective Randomised Comparative Study

Journal of Onco-Anaesthesiology and Perioperative Medicine
Background and Aims: This randomised double blinded comparative study of single bolus dose of epidural 0.2% ropivacaine with morphine versus intrathecal 0.2% ropivacaine with morphine was undertaken to evaluate their efficacy as intraoperative and ...
Nori Hari Chandan, Soumya Samal, Madhusmita Patro   +2 more
doaj   +1 more source

Intrathecal Drug Delivery

Intrathecal drug delivery systems are a means to provide direct administration of medications into the cerebrospinal fluid (CSF). Bypassing the blood-brain barrier allows a significantly lower dose of medication to be administered to attain analgesia ...
Chandran, S
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Intrathecal opioid medication for perioperative analgesia in severely handicapped children undergoing spinal operations [PDF]

, 2010
The use of intrathecal opioids for perioperative pain control from spinal fusion in severely handicapped children is feasible. Intrathecal opioids provide adequate postoperative analgesia and allow early extubation without persisting relevant respiratory
M. Weiss, Frotzler, A, B. Salgo, C.M. Dillier, A.C. Gerber, Dillier, C M, Gerber, A C, Schmitz, A, A. Frotzler, Salgo, B, Weiss, M, A. Schmitz   +11 more
core   +1 more source

Hypothermia With Paradoxical Symptoms: A Case Series of Cesarean Deliveries With Intrathecal Morphine

, 2023
Women receiving intrathecal morphine for cesarean delivery may experience hypothermia with paradoxical symptoms of sweating, nausea, and shivering. Despite being relatively rare in comparison to commonly experienced symptoms of perioperative hypothermia,
Judy Munday, Sonya Osborne, Kathryn Kynoch, Maffey, Simon, Osborne, Sonya, Munday, Judy, Victoria Steelman, Simon Maffey, Kynoch, Kathryn, Steelman, Victoria, Mary‐Anne Ramis, Ramis, Mary-Anne   +11 more
core   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

A comparative study of three different doses of nalbuphine as an adjuvant to intrathecal bupivacaine for postoperative analgesia in abdominal hysterectomy

Indian Journal of Pain, 2016
Background: Spinal anesthesia is still the most commonly used technique for lower abdominal surgeries as it is very economical and easy to administer. Its main disadvantage remains the short duration of action.
Fareed Ahmed, Hunny Narula, Mamta Khandelwal, Debojyoti Dutta   +3 more
doaj   +1 more source

Super analgesia of intrathecal morphine may be related to ABCB1 (MDR1) gene polymorphism

, 2018
Wangjun Qin,1,* Botao Liu,2,* Ang Deng,1 Ying Liu,1 Xianglin Zhang,1 Lei Zhang1 1Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China; 2Department of Pain Management, China-Japan Friendship Hospital, Beijing, China *These authors ...
Liu Y, Liu BT, Deng A, Zhang L, Zhang XL, Qin WJ   +5 more
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EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Intrathecal baclofen therapy

, 2014
Intrathecal baclofen therapy has been used in the treatment of severe, intractable spasticity resistant to oral agents in brain and spinal cord injury since 1992.
Khan, A
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