Results 71 to 80 of about 74,181 (306)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

A comparative study of three different doses of nalbuphine as an adjuvant to intrathecal bupivacaine for postoperative analgesia in abdominal hysterectomy

Indian Journal of Pain, 2016
Background: Spinal anesthesia is still the most commonly used technique for lower abdominal surgeries as it is very economical and easy to administer. Its main disadvantage remains the short duration of action.
Fareed Ahmed, Hunny Narula, Mamta Khandelwal, Debojyoti Dutta   +3 more
doaj   +1 more source

Super analgesia of intrathecal morphine may be related to ABCB1 (MDR1) gene polymorphism

, 2018
Wangjun Qin,1,* Botao Liu,2,* Ang Deng,1 Ying Liu,1 Xianglin Zhang,1 Lei Zhang1 1Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China; 2Department of Pain Management, China-Japan Friendship Hospital, Beijing, China *These authors ...
Liu Y, Liu BT, Deng A, Zhang L, Zhang XL, Qin WJ   +5 more
core  

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Resolution of chronic migraine headaches with intrathecal ziconotide: a case report

, 2015
Sachin Narain,1 Lama Al-Khoury,2 Eric Chang3–6 1Department of Anesthesiology and Perioperative Care, 2Department of Neurology, 3Department of Physical Medicine and Rehabilitation, 4Department of Neurosurgery, 5Department of Orthopedics, 6Reeve ...
Narain S, Chang E, Al-Khoury L
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Intrathecal Morphine versus Morphine-Dexmedetomidine Combination for Postoperative Pain Control After Total Knee Replacement: A Randomized Controlled Trial

, 2023
Amany F Omara,1 Hadal Hassan Mohsen,2 Alaa Mohammed Abo Hagar,1 Ahmed F Abdelrahman1 1Department of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Anaesthesia and Surgical Intensive Care ...
Mohammed Abo Hagar A, Mohsen HH, Abdelrahman AF, Omara AF   +3 more
core  

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Comparative study between the effect of intravenous or intrathecal dexmedetomidine on bupivacaine spinal block in lower abdominal surgery

Al-Azhar Assiut Medical Journal
Background and aim Dexmedetomidine has been shown to prolong spinal anesthesia and enhance postoperative analgesia when given intravenously or intrathecally.
Hayam S. Soliman, Ezzat M.A. Al-Saudi, Ahmed A. Mansour   +2 more
doaj   +1 more source

Bupivacaine sparing effect of intrathecal midazolam in sub-arachnoid block for cesarean section

Journal of Obstetric Anaesthesia and Critical Care, 2013
Background: Hypotension during subarachnoid block for caesarean section (CS) is the most common and potentially dangerous complication. Bupivacaine has been implicated for this effect in a dose dependent manner.
Manoj K Sanwal, Neha Baduni, Aruna Jain
doaj   +1 more source

Intrathecal Morphine and Ropivacaine for Quality of Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial [PDF]

Ying Yang,1,* Wenjun Lin,1,* Yifen Zhuo,2,* Yuxin Luo,1 Xiaoyan Wu,1 Junyu Li,1 Yusheng Yao1 1Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, Fujian, People’s ...
Yang Y, Li J, Yao Y, Zhuo Y, Lin W, Luo Y, Wu X   +6 more
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