Results 61 to 70 of about 74,181 (306)

A Comparative Study between Intrathecal Clonidine and Neostigmine with Intrathecal Bupivacaine for lower abdominal surgeries [PDF]

, 2017
Background: Limited duration of time has been one of the main drawback of spinal anesthesia.To avoid this adjuvants have been added to the local anesthetic agent and has proven benefits when used intrathecally.
Dr. Ashok Gunda, A Srikanth Reddy, Anil Kumar K, Syed Ali Aasim2   +3 more
core   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Intrathecal Drug Delivery Systems

, 2018
Intrathecal drug delivery (ITDD), while initially intended for terminal oncology patients suffering from cancer pain, is currently widely used for chronic nonmalignant pain states.
Ifeyinwa C. Ifeanyi, Mercy A. Udoji, Deepti Agarwal   +2 more
core   +1 more source

Engineering metalloporphyrin-integrated nanosystems for targeted sono-/ chemo- dynamic therapy of leptomeningeal carcinomatosis through intrathecal administration

, 2022
Leptomeningeal carcinomatosis (LMC) is a severe complication of cancers that markedly shortens survival and lowers the quality of patients’ life, and it still lacks adequate therapeutic programs.
Shu, Chaoqin, Wu, Aijun, Jin, Jie, Zhu, Yufang, Niu, Huicong, Qi, Xuejiao, Xiao, Yin, Wu, Chengtie, Bu, Hui, Chen, Jiajie, Bai, Kaixuan   +10 more
core   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Efficacy of Single Bolus Epidural Injection of 0.2% Ropivacaine and Morphine versus Intrathecal 0.2% Ropivacaine and Morphine in Patients Undergoing Laparotomy – A Prospective Randomised Comparative Study

Journal of Onco-Anaesthesiology and Perioperative Medicine
Background and Aims: This randomised double blinded comparative study of single bolus dose of epidural 0.2% ropivacaine with morphine versus intrathecal 0.2% ropivacaine with morphine was undertaken to evaluate their efficacy as intraoperative and ...
Nori Hari Chandan, Soumya Samal, Madhusmita Patro   +2 more
doaj   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Intrathecal Drug Delivery Trialing

, 2022
Intrathecal drug delivery has been used since the 1980s to treat spasticity as well as chronic malignant and nonmalignant pain symptoms. Patients that are considered for intrathecal drug delivery systems are those with chronic pain or severe spasticity ...
Bux, Anjum, Chopra, Pooja
core   +1 more source

Symptomatic intrathecal hypertension [PDF]

Neurology Clinical Practice, 2015
The Monro-Kellie doctrine states that since the cranium is an incompressible space, the sum of its contents must remain constant. An increase in one component must be accompanied by a decrease in another component, and even a small increase in the intracranial contents can result in a marked increase in intracranial pressure, causing pain and ...
Awss, Zidan, Deborah Young, Bradshaw
openaire   +2 more sources