Results 41 to 50 of about 76,887 (294)

Intrathecal morphine related perioperative hypothermia in women undergoing caesarean section: A retrospective case-control study

, 2018
Purpose: Rates of inadvertent perioperative hypothermia among women undergoing spinal anesthesia for cesarean delivery are reported to be high. Intrathecal morphine has been noted to have a potentially potent effect on thermoregulation.
Judy Munday, Yates, Patsy, Sonya Osborne, Osborne, Sonya, Patsy Yates, Munday, Judy   +5 more
core   +1 more source

Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery

Molecular Therapy: Methods & Clinical Development, 2017
Intravenous administration of adeno-associated virus serotype 9 (AAV9)/hMECP2 has been shown to extend the lifespan of Mecp2−/y mice, but this delivery route induces liver toxicity in wild-type (WT) mice.
Sarah E. Sinnett, Ralph D. Hector, Kamal K.E. Gadalla, Clifford Heindel, Daphne Chen, Violeta Zaric, Mark E.S. Bailey, Stuart R. Cobb, Steven J. Gray   +8 more
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

Acute pain management after kidney transplantation: A current review of literature

Indian Journal of Transplantation, 2023
Acute postoperative pain management after kidney transplantation is essential for early recovery and good patient satisfaction, but no formal review or guideline is available in the literature.
Vipin Kumar Goyal, Sony Mandal, Ganesh Ramaji Nimje, Praveenkumar Shekhrajka, Pankaj Singh Rana, Saurabh Mittal   +5 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Intrathecal methotrexate-induced acute cerebellar syndrome

, 2003
Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment. We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate ...
Uzel, B, Ongoren, S, Forta, H, Ar, CM, Necioglu, D, Ferhanoglu, B   +5 more
core   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression

Journal of the Formosan Medical Association, 2016
We previously showed that subsequent intrathecal (i.t.) injection of resveratrol (30 μg) significantly reverses morphine-evoked neuroinflammation in morphine-tolerant rats. The present study examined the underlying mechanism.
Ru-Yin Tsai, Juei-Chii Wang, Kuang-Yi Chou, Chih-Shung Wong, Chen-Hwan Cherng   +4 more
doaj   +1 more source

Symptomatic intrathecal hypertension [PDF]

Neurology Clinical Practice, 2015
The Monro-Kellie doctrine states that since the cranium is an incompressible space, the sum of its contents must remain constant. An increase in one component must be accompanied by a decrease in another component, and even a small increase in the intracranial contents can result in a marked increase in intracranial pressure, causing pain and ...
Awss, Zidan, Deborah Young, Bradshaw
openaire   +2 more sources

Intrathecal drug delivery and neurolytic blocks

, 2010
Intrathecal drug delivery (ITDD) allows drugs to be placed near to central receptors Drug side-effects may be reduced as small doses are required compared to with systemic administration
Karen H. Simpson, Iain Jones
core   +1 more source