Results 31 to 40 of about 99,994 (292)

Fast glycorrhachia and cerebrospinal fluid protein as predictors of sensory block in anesthesia with subarachnoid Ropivacaine [PDF]

, 2016
BACKGROUND: Identify if glycorrhachia and cerebrospinal fluid protein could influence the time of sensory block to T10, the duration and the metameric block's level, after a standard dose of Ropivacaine. METHODS: 80 patients, ASA I - III undergoing to
COLLINI, Saul, DE SIO, SIMONE, MERLIN, PAMELA, PACELLA, Elena, PACELLA, FERNANDA, Troisi, F   +5 more
core   +1 more source

Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]

, 2015
Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine, Ramachandran, Roshni, Yaksh, Tony L   +2 more
core   +2 more sources

A prospective, double-blind dose-ranging study of intrathecal nalbuphine in the lower abdominal and lower limb surgeries

Indian Journal of Pain, 2016
Background: Nalbuphine is a synthetic opioid with mixed agonist-antagonist action, used as an adjuvant with intrathecal bupivacaine to prolong postoperative analgesia.
Sandip Roy Basunia, Suman Chattopadhyay, Aditi Das, Baishaki Laha, Debasish Bhar, Rita Pal   +5 more
doaj   +1 more source

Circuit dissection of the role of somatostatin in itch and pain [PDF]

, 2018
Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood.
AJ Christensen, AJ Todd, Allen C. Dickie, AM Bell, Andrew J. Todd, AP Kardon, B Duan, BL Roth, BN Armbruster, C Peirs, C Solorzano, CE Pichon Le, CL Li, D Bröhl, D Usoskin, DM Bautista, DP Roberson, DR Simmons, E Foster, E Polgár, E Vasyutina, Erika Polgár, F Cevikbas, F Proudlock, GR Dressler, H Petitjean, H Taniguchi, Hanns Ulrich Zeilhofer, Hans Jürgen Solinski, Hendrik Wildner, I Bencivinni, IM Chiu, J Braz, J Chrubasik, Jing Huang, JL Hylden, John S. Riddell, KA Boyle, Kieran A. Boyle, KK Stantcheva, L Cui, L Han, L Li, L Madisen, L Madisen, M Gutierrez-Mecinas, M Gutierrez-Mecinas, M Gutierrez-Mecinas, Mark A. Hoon, Masahiko Watanabe, Mette C. Kriegbaum, MJ Krashes, MQ Nguyen, Noboru Iwagaki, P Taurà, Pang-Yen Tseng, PS Danielian, RJ Mullen, S Sun, Santosh K. Mishra, SE Ross, SK Mishra, SK Mishra, SK Mishra, SM Carlton, SM Carlton, SR Chaplan, T Akiyama, T Hökfelt, T Hökfelt, T Lee, T Yasaka, T Zeyda, V Chapman, VE Abraira, VS Seybold, Y Lu, YG Sun, YG Sun, Z Wiesenfeld-Hallin   +79 more
core   +1 more source

Intrathecal injection of bone marrow concentrate in children with autism spectrum disorder: a retrospective chart analysis

Frontiers in Medicine
BackgroundThe growing prevalence of autism spectrum disorder (ASD) underscores the urgent need for therapies that target underlying biological mechanisms, with cell-based interventions offering a potentially transformative approach by targeting core ...
Georg S. Kobinia, Georg S. Kobinia, Adam Bukaty, Elisabeth Holly, Gloria Kobinia, Gloria Kobinia, Philipp R. Heuberer, Philipp R. Heuberer, Brenda Laky, Brenda Laky, Brenda Laky, Brenda Laky   +11 more
doaj   +1 more source

Comparison of nalbuphine versus fentanyl as intrathecal adjuvant to bupivacaine for orthopedic surgeries: A randomized controlled double-blind trial

Journal of Anaesthesiology Clinical Pharmacology, 2021
Background and Aims: Intrathecal adjuvants are used with local anesthetics to prolong the duration and provide postoperative pain relief while minimizing the dose of local anesthetic.
Ankit Sharma, Sujata Chaudhary, Mahendra Kumar, Ruchi Kapoor   +3 more
doaj   +1 more source

Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]

, 2018
Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni, Alberto Macone, Atul Dolas, Jessica Dragotto, Maria Teresa Fiorenza, Paola Caporali, Ramesh Jayaraman, Sandeep Goyal, Soniya Johny   +8 more
core   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Emerging treatment options for the management of brain metastases in patients with HER2-positive metastatic breast cancer. [PDF]

, 2013
The widespread use of trastuzumab in the past decade has led to a significant and measureable improvement in the survival of patients with human epidermal growth factor receptor-2 (HER2) overexpressing breast cancer, and in many ways has redefined the ...
Chien, A Jo, Rugo, Hope S
core   +1 more source

Intrathecal B-cell activation in LGI1 antibody encephalitis. [PDF]

, 2020
ObjectiveTo study intrathecal B-cell activity in leucine-rich, glioma-inactivated 1 (LGI1) antibody encephalitis. In patients with LGI1 antibodies, the lack of CSF lymphocytosis or oligoclonal bands and serum-predominant LGI1 antibodies suggests a ...
Dandekar, Ravi, Gelfand, Jeffrey M, Geschwind, Michael D, Greenfield, Ariele L, Irani, Sarosh R, Jahn, Sarah, Lehmann-Horn, Klaus, Lepennetier, Gildas, Michael, Sophia, Palanichamy, Arumugam, von Büdingen, H-Christian, Wang, Shengzhi, Wilson, Michael R, Zamvil, Scott S   +13 more
core