Results 11 to 20 of about 99,994 (292)
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Cerebrospinal fluid (CSF) molecular exchange with brain interstitial fluid (ISF) and periphery is implicated in neurological disorders but needs better quantitative clinical assessment approaches.
Ajay Verma +7 more
doaj +1 more source
Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]
, 2012 Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
A Hainard +44 more
core +4 more sources
Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice [PDF]
, 2018 Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential because of their adverse side effects. Novel approaches targeting the NR2B-PSD95-
Chawla, Aarti +6 more
core +1 more source
Frontiers in Molecular Neuroscience, 2023 While the majority of gene therapy studies in neurological indications have focused on direct gene transfer to the central nervous system (CNS), there is growing interest in the delivery of therapeutics using the cerebrospinal fluid (CSF) as a conduit ...
Ernesto A. Salegio +2 more
doaj +1 more source
Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model [PDF]
, 2012 Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents.
Itano, Yoshitaro +10 more
core +1 more source
Neurotherapeutics, 2008 Direct neuroaxis drug delivery has expanded the physician's armamentarium to provide treatment options to those who have failed more conservative interventions. Starting from Bier's 'cocainization of the spinal cord' in 1898, direct nervous system pharmacy delivery has long been recognized as an effective means to treat pain.
Shawn, Belverud +2 more
openaire +2 more sources
Antinociceptive drug interaction between intrathecal vitamin E and gabapentin in the rat formalin test [PDF]
Korean Journal of Anesthesiology, 2012 BackgroundGabapentin is thought to exert an effect through the voltage-dependent calcium channel. Vitamin E is a widely known antioxidant which neutralizes the harmful effect of ROS which is considered to play a prominent role in various painful ...
Myoung-Joong Kim +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 The inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain perception. However, in post-surgical pain, the exact mechanism and modes of action of GABAergic transmission have been poorly studied ...
Bruno Pradier +4 more
doaj +1 more source
Transient neurologic symptoms following spinal anesthesia with isobaric mepivacaine: A decade of experience at Toronto Western Hospital [PDF]
, 2018 Background: Transient neurologic symptoms (TNSs) can be distressing for patients and providers following uneventful spinal anesthesia. Spinal mepivacaine may be less commonly associated with TNS than lidocaine; however, reported rates of TNS with ...
Abdallah, Faraj W. +4 more
core +2 more sources
AAV-mediated gene transfer to colon-innervating primary afferent neurons
Frontiers in Pain Research, 2023 Investigation of neural circuits underlying visceral pain is hampered by the difficulty in achieving selective manipulations of individual circuit components.
Reshma Gore +12 more
doaj +1 more source