Results 21 to 30 of about 76,887 (294)

Effects of fadolmidine, an α2‐adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs

Pharmacology Research & Perspectives, 2021
α2‐Adrenoceptor agonists such as clonidine and dexmedetomidine are used as adjuvants to local anesthetics in regional anesthesia. Fadolmidine is an α2‐adrenoceptor agonist developed especially as a spinal analgesic.
Tiina Leino, Timo Viitamaa, Jarmo S. Salonen, Ullamari Pesonen, Antti Haapalinna   +4 more
doaj   +1 more source

A comparative study of the effect of clonidine, fentanyl, and the combination of both as adjuvant to intrathecal bupivacaine for postoperative analgesia in total abdominal hysterectomy

Journal of Anaesthesiology Clinical Pharmacology, 2017
Background and Aims: The aim of this study was to evaluate the level of sensory block, onset and duration of motor block, postoperative analgesia, and adverse effects of combination of clonidine and fentanyl given intrathecally with hyperbaric ...
Fareed Ahmed, Mamta Khandelwal, Anil Sharma   +2 more
doaj   +1 more source

Intrathecal 99mTc‐DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Cerebrospinal fluid (CSF) molecular exchange with brain interstitial fluid (ISF) and periphery is implicated in neurological disorders but needs better quantitative clinical assessment approaches.
Ajay Verma, Jacob Y. Hesterman, J. Levi Chazen, Robert Holt, Patrick Connolly, Laura Horky, Shankar Vallabhajosula, P. David Mozley   +7 more
doaj   +1 more source

Pre-clinical delivery of gene therapy products to the cerebrospinal fluid: challenges and considerations for clinical translation

Frontiers in Molecular Neuroscience, 2023
While the majority of gene therapy studies in neurological indications have focused on direct gene transfer to the central nervous system (CNS), there is growing interest in the delivery of therapeutics using the cerebrospinal fluid (CSF) as a conduit ...
Ernesto A. Salegio, Kelli Hancock, Stephanie Korszen   +2 more
doaj   +1 more source

Antinociceptive drug interaction between intrathecal vitamin E and gabapentin in the rat formalin test [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundGabapentin is thought to exert an effect through the voltage-dependent calcium channel. Vitamin E is a widely known antioxidant which neutralizes the harmful effect of ROS which is considered to play a prominent role in various painful ...
Myoung-Joong Kim, Won Hyung Lee, Young-Kwon Ko, Boo Hwi Hong   +3 more
doaj   +1 more source

Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury

Frontiers in Molecular Neuroscience, 2023
The inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain perception. However, in post-surgical pain, the exact mechanism and modes of action of GABAergic transmission have been poorly studied ...
Bruno Pradier, Daniel Segelcke, Sylvia Reichl, P. K. Zahn, E. M. Pogatzki-Zahn   +4 more
doaj   +1 more source

Computed Tomography-Derived Occipital–Coccygeal Length and Ilium Wing Distance Correlates with Skin to Epidural and Intrathecal Depths in Dogs

Veterinary Sciences, 2020
The current clinical techniques for neuraxial needle placement in dogs are predominantly blind without prior knowledge of the depth required to reach the desired space.
Tsim Christopher Sun, Mariano Makara, Fernando Martinez-Taboada   +2 more
doaj   +1 more source

AAV-mediated gene transfer to colon-innervating primary afferent neurons

Frontiers in Pain Research, 2023
Investigation of neural circuits underlying visceral pain is hampered by the difficulty in achieving selective manipulations of individual circuit components.
Reshma Gore, Tina Esmail, Kelsey Pflepsen, Ezequiel Marron Fernandez de Velasco, Kelley F. Kitto, Maureen S. Riedl, Andrea Karlen, R. Scott McIvor, Christopher N. Honda, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Carolyn A. Fairbanks, Lucy Vulchanova   +12 more
doaj   +1 more source

Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study

Indian Journal of Anaesthesia, 2015
Background and Aims: Dexmedetomidine (DMT), as intrathecal adjuvant has been shown to successfully prolong duration of analgesia but delay the motor recovery.
K Sudheesh, R S Raghavendra Rao, M Kavya, J Aarthi, D Devika Rani, S S Nethra   +5 more
doaj   +1 more source

Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease

Molecular Therapy: Methods & Clinical Development, 2017
Late infantile neuronal ceroid lipofuscinosis (LINCL) is a fatal inherited neurodegenerative disease caused by loss of lysosomal protease tripeptidyl peptidase 1 (TPP1).
Jennifer A. Wiseman, Yu Meng, Yuliya Nemtsova, Paul G. Matteson, James H. Millonig, Dirk F. Moore, David E. Sleat, Peter Lobel   +7 more
doaj   +1 more source