Results 41 to 50 of about 3,938 (215)

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo

, 2009
Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan, Stefan Brugger, Martina Kurejova, Tegeder Imgard, Gangadharan Vijayan, Imgard Tegeder, Gangadharan, Vijayan, Tegeder, Irmgard, Kuner Rohini, Kurejova, Martina, Rohini Kuner, Kurejova Martina, Nitin Agarwal, Bernhard Bettler, Brugger Stefan, Vijayan Gangadharan, Tegeder, Imgard, Agarwal, Nitin, Bettler Bernhard, Bettler, Bernhard, Agarwal Nitin, Kuner, Rohini   +21 more
core   +1 more source

Bladder stones – red herring for resurgence of spasticity in a spinal cord injury patient with implantation of Medtronic Synchromed pump for intrathecal delivery of baclofen – a case report

BMC Urology, 2003
Background Increased spasms in spinal cord injury (SCI) patients, whose spasticity was previously well controlled with intrathecal baclofen therapy, are due to (in order of frequency) drug tolerance, increased stimulus, low reservoir volume, catheter ...
Singh Gurpreet, Hughes Peter L, Oo Tun, Soni Bakul M, Vaidyanathan Subramanian, Watt John WH, Sett Pradipkumar   +6 more
doaj   +1 more source

Intrathecal baclofen therapy

Rinsho Shinkeigaku, 2010
Intrathecal baclofen therapy (ITB) is a surgical treatment of spasticity by administrating small amount of baclofen directly into the spinal intrathecal space. This has been developed over the past twenty years, and now it is a well-established procedure.
openaire   +3 more sources

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Unusual mechanical failures of intrathecal baclofen pump systems: symptoms, signs, and trouble shooting

, 2021
Introduction!#!Although intrathecal baclofen (ITB) therapy is an effective treatment for spasticity, it has several disadvantages and a risk of complications.!##!Methods!#!We present six pediatric patients who suffered from unusual mechanical failures of
Gburek-Augustat, Janina, Krause, Matthias, Gräfe, Daniel, Nestler, Ulf, Sorge, Ina, Bernhard, Matthias, Siekmeyer, Manuela, Merkenschlager, Andreas   +7 more
core   +1 more source

A Swedish Population‐Based Study Found That Muscle Hypertonia in Children With Cerebral Palsy Varied by Age, Subtype, Functional Level, and Muscle Group

Acta Paediatrica, EarlyView.
ABSTRACT Aim We examined how lower limb muscle tone was related to age, sex, Gross Motor Function Classification System (GMFCS) level, and the cerebral palsy (CP) subtype in Swedish children with CP. Methods This registry‐based cohort study from 2023 to 2024 used data on all 3 216 children aged 1–15 from the Swedish follow‐up program and national CP ...
Gunnar. Hägglund, Ann. I. Alriksson‐Schmidt   +1 more
wiley   +1 more source

Intrathecal baclofen for treating spasticity in children with cerebral palsy

, 2015
BACKGROUND: Cerebral palsy is a disorder of movement and posture arising from a non‐progressive lesion in the developing brain. Spasticity, a disorder of increased muscle tone, is the most common motor difficulty and is associated with activity ...
Rice, James E, Hasnat, Monika J
core   +1 more source

Musculoskeletal Pain Outcomes Pre- and Post Intrathecal Baclofen Pump Implant in Children With Cerebral Palsy: A Prospective Cohort Study

Archives of Rehabilitation Research and Clinical Translation, 2020
Objective: To characterize musculoskeletal pain intensity, duration, frequency, and interference with activities of daily living in children with cerebral palsy (CP) before and after intrathecal baclofen pump placement.
Chantel C. Barney, PhD, Alyssa M. Merbler, MA, Jean Stansbury, APRN, Linda E. Krach, MD, Michael Partington, MD, Patrick Graupman, MD, Peter D. Kim, MD, PhD, Debbie Song, MD, Frank J. Symons, PhD   +8 more
doaj   +1 more source

Systemic and intrathecal baclofen produce bladder antinociception in rats

BMC Urology, 2021
Background Baclofen, a clinically available GABAB receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested for effects on bladder nociception.
Timothy J. Ness, Alan Randich, Xin Su, Cary DeWitte, Keith Hildebrand   +4 more
doaj   +1 more source

Look Before You Leap: When ITB Pumps Fail

Indian Journal of Physical Medicine & Rehabilitation, 2022
A 32-year-old male presented with uncontrolled hip flexor spasms. He suffered a spinal cord injury and was put on an intrathecal baclofen pump. Despite escalating doses, his spasticity was not controlled.
Ravi Sankaran, Greeshma Varun
doaj   +1 more source