Results 61 to 70 of about 3,938 (215)

The Effect of Intrathecal Baclofen in Dyskinetic Cerebral Palsy: The IDYS Trial

, 2019
Objective Intrathecal baclofen treatment is used for the treatment of dystonia in patients with severe dyskinetic cerebral palsy; however, the current level of evidence for the effect is low.
Strijers, Rob L. M., van Ouwerkerk, Willem J. R., van de Ven, Peter, Becher, Jules G., Fleuren, Sabine, Teernstra, Onno P., Bonouvrie, Laura A., Vles, Johan S. H., Vermeulen, R. Jeroen, Foncke, Elisabeth M. J., Geytenbeek, Johanna J. M., de Groot, Vincent, van de Pol, Laura A., Slot, K. M., Soudant, Dan, Peerdeman, S. M., Twisk, Jos W. R., Boeschoten, Karin   +17 more
core   +2 more sources

2025 Consensus Clinical Management Guidelines for Niemann‐Pick Disease Type C

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT In 2018, the International Niemann‐Pick Disease Alliance (INPDA) and the International Niemann‐Pick Disease Registry (INPDR) developed and published comprehensive clinical management guidelines to support inclusive and standardized care pathways in Niemann‐Pick disease type C (NPC)—an ultra‐rare, autosomal recessive, neurovisceral lysosomal ...
Tarekegn Hiwot, Forbes D. Porter, Tatiana Bremova‐Ertl, Uma Ramaswami, Caroline Hastings, Bénédicte Héron, Justin Hopkin, Joella Melville, Hernan Amartino, Mireia del Toro, Federica Deodato, Fatih Ezgü, Paul Gissen, James B. Gibson, Can Ficicioglu, Roberto Giugliani, Orna Staretz‐Chacham, Frances Platt, Nathalie Guffon, Kristina Julich, Nikola Kresojević, Anna Lehman, Yann Nadjar, Susanne A. Schneider, Simon Jones, Eugen Mengel, Michel Tchan, Mark Walterfang, Ozlem Goker‐Alpan, Charlotte Dawson, Sandra Cowie, Toni Mathieson, Elizabeth Berry‐Kravis, Marc C. Patterson   +33 more
wiley   +1 more source

Long‐Term Outcomes in Stiff Person Spectrum Disorder

European Journal of Neurology, Volume 33, Issue 5, May 2026.
ABSTRACT Background Long‐term outcome data for stiff person spectrum disorder (SPSD) remain limited and sustained response to treatment varies. Methods In this retrospective cohort study, we included patients with probable or definite SPSD (Mayo Clinic criteria), evaluated at Mayo Clinic (12/1995‐07/2024) with ≥ 5 years of follow‐up after diagnosis ...
Georgios Mangioris, Andrew McKeon, James H. Bower, Nisa Vorasoot, Divyanshu Dubey, Eoin P. Flanagan, Sean J. Pittock, Anastasia Zekeridou   +7 more
wiley   +1 more source

Clobazam to preserve meaningful engagement in prolonged disorder of consciousness with concurrent seizure disorder

PM&R, EarlyView.
Tatiana Bernstein, Zachary Miklja, Tiffany Wood, Joshua Startup   +3 more
wiley   +1 more source

New Perspectives on the Efficacy of Governor Vessel Moxibustion Combined With Rehabilitation Training for Poststroke Muscle Spasticity: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Brain and Behavior, Volume 16, Issue 4, April 2026.
(A) Picture of GVM treatment, (B) roles of TCM practitioner, (C) RT at different stages from acute to chronic stroke, (D) schematic diagram of GVM, (E) pathogenesis of PSS, and (F) possible antispastic mechanisms of GVM. Abbreviations: BI/MBI, Barthel Index/modified Barthel Index; CRT, cortico‐reticular tract; CSI, composite spasticity index; CST ...
Jun‐Xiang Wang, Zhe‐Hao Hu, Yi‐Yang Song, Jin‐Shan Zhong, Miao He   +4 more
wiley   +1 more source

Aicardi‐Goutières Syndrome Type 6: Case Report and Structural Prediction Supporting a Dominant‐Negative Effect of the ADAR1 c.3019G>A Variant

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Aicardi–Goutières syndrome type 6 (AGS6) is a genetically determined autoinflammatory disorder, classically inherited in an autosomal recessive manner. We report a Czech child with a heterozygous ADAR1 NM_001111.5:c.3019G>A variant causing AGS6.
Katerina Turan, Petra Pokorna, Kamila Rihova, Jana Kubatova, Katerina Kozelkova, Eliska Hlouskova, Pavlina Danhofer, Petr Jabandziev, Jiri Damborsky, Regina Demlova, Ondrej Slaby, Katerina Slaba   +11 more
wiley   +1 more source

Intrathecal baclofen treatment in dystonic cerebral palsy: a randomized clinical trial: the IDYS trial

, 2013
Background: Dystonic cerebral palsy is primarily caused by damage to the basal ganglia and central cortex. The daily care of these patients can be difficult due to dystonic movements.
Strijers, Rob L. M., Dan Soudant, van Ouwerkerk, Willem J. R., Becher, J.G., Becher, Jules G., van Ouwerkerk, W.J.R., van de Ven, P.M., Geytenbeek, J.J.M., Bonouvrie, Laura A., Vincent de Groot, Bonouvrié, L.A., Laura A Bonouvrié, Joke Geytenbeek, Vermeulen, R.J., Jules G Becher, de Groot, V., Rob LM Strijers, Vles, Johannes S. H., Boeschoten, Karin, Strijers, R.L.M., Elisabeth Foncke, Geytenbeek, Joke, Willem JR van Ouwerkerk, R Jeroen Vermeulen, Teernstra, Onno, Karin Boeschoten, Peter M van de Ven, Johannes SH Vles, van de Ven, Peter M., Vermeulen, R. Jeroen, Teernstra, O., Foncke, Elisabeth, Vles, J.S.H., Boeschoten, K., Foncke, E., de Groot, Vincent, Onno Teernstra, Soudant, D., Soudant, Dan   +38 more
core   +1 more source

Efficacy and Safety of Baclofen 40 mg/20 mL in an Intrathecal Infusion System

Life
Background: Spasticity is a common feature of Upper Motoneuron Syndrome and is frequently treated with intrathecal baclofen (ITB) when oral therapy is ineffective or poorly tolerated. Different baclofen formulations are available for intrathecal use, but
Riccardo Marvulli, Serena Gervasi, Giuseppa Lagioia, Lucrezia Dell’Olio, Serena Caforio Montesardo, Marisa Megna, Maurizio Ranieri   +6 more
doaj   +1 more source

Intrathecal baclofen toxicity in a patient with acute kidney injury

Journal of Pediatric Rehabilitation Medicine, 2019
A 9-year old male patient with a past medical history of congenital cytomegalovirus (CMV) infection and spastic quadriplegic cerebral palsy with an intrathecal baclofen pump was admitted to a tertiary care hospital with respiratory depression and ...
Angeline Bowman, Rita Ayyangar, Ian Gonzales, Joseph Hornyak   +3 more
doaj   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source