Results 21 to 30 of about 18,654 (227)

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

Efficacy and Safety of Ropivacaine Addition to Intrathecal Morphine for Pain Management in Intractable Cancer

Mediators of Inflammation, 2015
Objective. Although intrathecal drug infusion has been commonly adopted for terminal cancer pain relief, its adverse effects have made many clinicians reluctant to employ it for intractable cancer pain.
Ying Huang, Xihan Li, Tong Zhu, Jian Lin, Gaojian Tao   +4 more
doaj   +1 more source

Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]

, 2017
Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J, Hockman, Tyler M, Wiese, Ashley J, Yaksh, Tony L   +3 more
core   +2 more sources

Intrathecal morphine exacerbates paresis with increasing muscle tone of hindlimbs in rats with mild thoracic spinal cord injury but without damage of lumbar α-motoneurons.

PLoS ONE, 2022
Adverse effects of morphine on locomotor function after moderate to severe spinal cord injury (SCI) have been reported; however, the effects after mild SCI without damage of lumbar α-motoneurons have not been investigated.
Katsuhiro Kawakami, Satoshi Tanaka, Yuki Sugiyama, Noriaki Mochizuki, Mikito Kawamata   +4 more
doaj   +2 more sources

A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty [PDF]

, 2016
We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing ...
Anderson, K., Grant, A., Harrison, P., Kearns, R., Kinsella, J., Macfarlane, A., Puxty, K., Shaw, M.   +7 more
core   +1 more source

Intrathecal versus local infiltration analgesia for pain control in total joint arthroplasty

Journal of Orthopaedic Surgery and Research, 2020
Background The purpose of this meta-analysis was to assess the efficacy of intrathecal morphine (ITM) analgesia and local infiltration analgesia (LIA) for pain control in total joint arthroplasty (TJA).
Ai-Lan Cai, Sheng-Jie Liu, Bin Wu, Geng Liu   +3 more
doaj   +1 more source

Comparative study of morphine or dexmedetomidine as intrathecal adjuvants to 0.5% hyperbaric bupivacaine in infraumbilical surgeries

Indian Journal of Pain, 2019
Background: Morphine and Dexmedetomidine have been used with subarachnoid block for postoperative pain relief, sedation and analgesia. In higher doses, it may produce adverse effect on haemodynamics.
Mamta Khandelwal, Harshita Rao, Pradeep Kumar, Usha Bafna, Sonali Beniwal   +4 more
doaj   +1 more source

Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice

Frontiers in Pharmacology, 2022
Opioid tolerance, opioid-induced hyperalgesia during repeated opioid administration, and chronic pain are associated with upregulation of adenylyl cyclase activity.
Kayla Johnson, Alexis Doucette, Alexis Edwards, Aleeya Verdi, Ryan McFarland, Shelby Hulke, Amanda Fowler, Val J. Watts, Amanda H. Klein   +8 more
doaj   +1 more source

Effects of Intraperitoneal and Intrathecal Morphine Analgesia on the Expression of μ-Opioid Receptors in Bone Cancer Pain Rats

Dose-Response, 2019
Backgrounds: This study compared analgesic effects and μ-opioid receptor expression levels during long-term intraperitoneal and intrathecal treatment in a bone cancer pain rat.
Wei Liu, Heqi Liu, Zongde Zhang, Jiapeng Huang   +3 more
doaj   +1 more source

Remote intrathecal morphine preconditioning is ineffective in the presence of neuraxial blockade with lidocaine

Kaohsiung Journal of Medical Sciences, 2014
Remote intrathecal morphine preconditioning (RMPC) induces cardioprotection via a neural pathway. Intrathecal lidocaine (LID) blocks spinal cord nerve transmission. This study examine whether LID prevents the effects of RMPC.
Yao Lu, Gordon Tin Chun Wong, Ye Zhang, Jun Hu, Chunshan Dong   +4 more
doaj   +1 more source