Results 91 to 100 of about 1,649 (147)

Systemic EP4 receptor agonist and Arginase‐1 therapy in a murine model of chronic asthma and influenza virus‐induced asthma exacerbation

British Journal of Pharmacology, EarlyView.
Background and Purpose Myeloid‐derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP4 receptor agonist L‐902,688 and pegylated ...
Tim Lange, Tobias Brunn, Charlotte Vetter, Konstantin Bloch, Nora Vedder, Chiel van Geffen, Philipp Gercke, Saeed Kolahian   +7 more
wiley   +1 more source

DESCRIPTION OF AN APPARATUS FOR INTRATRACHEAL INSUFFLATION [PDF]

Journal of the American Medical Association, 1914
Intratracheal insufflation as a method of anesthesia is now well established. It has already been the means of saving lives as well as increasing the possibilities of surgery. It is unnecessary to deal here with the advantages and disadvantages of this method, as they have been discussed sufficiently in recent medical literature.
openaire   +3 more sources

Muscle transposition graft for closure of a permanent tracheostoma in a Quarter Horse mare

Equine Veterinary Education, EarlyView.
Summary Permanent tracheostomy is sometimes required in horses with severe and irreversible obstructive upper airway conditions. Abnormal respiratory noise and altered vocalisation may be of concern to owners and its influence on mare‐foal recognition and bonding should be considered.
G. P. Stemmet, R. Labens
wiley   +1 more source

Characteristics of oral mucosal pressure injuries in children with orotracheal intubation in intensive care units: An observational study

Nursing in Critical Care, EarlyView.
Abstract Background Tracheal intubation can be used for ventilation to ensure an unobstructed respiratory tract, and it is the most common respiratory support technique used in paediatric intensive care unit (PICU) patients. Orotracheal intubation is usually the preferred method of tracheal intubation. However, it can cause stress‐related damage to the
Yueyue Zhao, Jie Guo, Jie Ma, Yanjun Ge, Junna Wang, Conghui Li, Caixiao Shi   +6 more
wiley   +1 more source

Add‐On Dextromethorphan Improves the Effects of Pirfenidone in Bleomycin‐Treated Mice and Patients With Pulmonary Fibrosis

Respirology, EarlyView.
ABSTRACT Background and Objective Idiopathic pulmonary fibrosis is a progressive interstitial lung disease characterised by excessive activation of myofibroblasts. However, currently available antifibrotic drugs exhibit limited efficacy. The dysregulation of redox processes plays a significant role in the pathogenesis of idiopathic pulmonary fibrosis ...
Jie Huang, Nana Liu, Yueyue Jin, Shuangyu Han, Lian Li, Yunze Du, Luqing Wei, Dongsheng Li, Yan Zhang, Yubao Wang, Jau‐Shyong Hong, Wen Ning, Jing Feng   +12 more
wiley   +1 more source

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source

Mucous Permeable Nanoparticle for Inducing Cuproptosis‐Like Death In Broad‐Spectrum Bacteria for Nebulized Treatment of Acute Pneumonia

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Copper‐based nanoparticles doped with BSO, and modified with PEG, not only can it increase the retention ability and mucosal penetration ability in the lungs, but also induce cuproptosis‐like death in bacteria and inhibit bacterial TCA cycle. It can also inhibit bacterial quorum sensing, clear biofilms, reduce bacterial virulence, and thus exert ...
Huiqun Hu, Shiyuan Hua, Feng Lu, Wenting Zhang, Zengwen Zhang, Jiarong Cui, Xiaoyue Lei, Jingyan Xia, Feng Xu, Min Zhou   +9 more
wiley   +1 more source

NLRC4 Regulates Th2 Differentiation in Mice With Allergic Airway Inflammation Induced by House Dust Mite

Allergy, EarlyView.
So‐Won Pak, Woong‐Il Kim, Se‐Jin Lee, Junhyeong Lee, Min‐Jung Park, Jong‐Hwan Park, Jong‐Choon Kim, Taesoo Kim, Joong‐Sun Kim, Yun Hee Kim, In‐Sik Shin   +10 more
wiley   +1 more source

A Spleen‐Targeted Tolerogenic mRNA‐LNPs Vaccine for the Treatment of Experimental Asthma

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Splenic DCs‐targeted co‐delivery of nucleoside‐modified antigen mRNA and Cel‐loaded LNPs vaccine induces tolerogenic DCs and subsequent antigen‐specific CD4+ regulatory T cells for the treatment of experimental allergic asthma. Abstract Lipid nanoparticles (LNPs)‐based mRNA vaccines have witnessed their great advantages in the fight against infectious ...
Fazhan Wang, Jia Lou, Xiaohan Lou, Fang Wu, Xiaoke Gao, Xiaohan Yao, Jiajia Wan, Xixi Duan, Wenjing Deng, Lixia Ma, Lijing Zhang, Guangjie He, Ming Wang, Chen Ni, Ningjing Lei, Zhihai Qin   +15 more
wiley   +1 more source

Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide‐Induced Lung Injury in Obesity

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study reveals that in alveolar macrophages of high‐fat diet‐induced obese mice, the transcriptional repressor GFI1 is upregulated. This upregulation suppresses ACOD1 expression, which intensifies lipopolysaccharide‐induced lung inflammation and oxidative stress, thereby worsening acute lung injury. Abstract To investigate the mechanisms behind the
Jingyue Ma, Yichan Ao, Zhen Yue, Zhiqiao Wang, Xiangyu Hou, Hongbin Li, Hanbing Wang, Siqing Luo, Jianyu He, Zikun Duan, Ling Liu, Ke Wei   +11 more
wiley   +1 more source