Results 101 to 110 of about 35,236 (241)

A Novel Bioabsorbable Covered Stent for Advancing Bile Duct Injury Management: A Preclinical Study in a Porcine Model (With Video)

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Self‐expandable metallic and plastic stents have been used for biliary tract injuries, but they are not entirely adequate as treatments. This study investigated the potential of our novel self‐expandable bioabsorbable covered stent (SEBCS) to treat bile duct injuries. We developed a novel SEBCS by covering a self‐expandable bioabsorbable stent
Mitsuo Miyazawa   +6 more
wiley   +1 more source

Epithelial Atg5 Deficiency Intensifies Caspase‐11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS–STING–NLRP3 Axis in Macrophages During Pseudomonas Infection

open access: yesMedComm, Volume 6, Issue 7, July 2025.
This work illuminates the essential role of epithelial ATG5 in defending against P. aeruginosa. Atg5 deficiency impairs bacterial clearance and aggravates inflammation via AKT/PI3K/NF‐κB, inflammasome activation, and pyroptosis. Mechanistically, impaired mitophagy intensifies mitochondrial damage.
Junyi Wang   +10 more
wiley   +1 more source

ILC2 Diversity, Location, and Function in Pulmonary Disease

open access: yesImmunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT Type‐2 inflammation is driven by the production of canonical type‐2 cytokines IL‐4, IL‐5, and IL‐13. Type‐2 cytokines promote mucus production, innate immune cell recruitment, and smooth muscle contractility in mucosal tissues. These hallmarks of type‐2 inflammation are important contributors to the weep‐and‐sweep responses observed in the ...
Mukesh Verma   +2 more
wiley   +1 more source

Multifaceted Role of Microbiota‐Derived Indole‐3‐Acetic Acid in Human Diseases and Its Potential Clinical Application

open access: yesThe FASEB Journal, Volume 39, Issue 11, 15 June 2025.
The complexity of indole‐3‐acetic acid's (IAA's) role in human health and disease. IAA is a multifaceted compound with significant consequences for several physiological and pathological processes. ABSTRACT Indole‐3‐acetic acid (IAA) is recognized as a common plant growth hormone.
Nargis Shaheen   +4 more
wiley   +1 more source

Micro‐ and Nano‐Bots for Infection Control

open access: yesAdvanced Materials, Volume 37, Issue 24, June 19, 2025.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady   +5 more
wiley   +1 more source

The Lung Microbiome Modulates Pain‐Like Behavior Via the Lung–Brain Axis in a Nitroglycerin‐Induced Chronic Migraine Mouse Model

open access: yesAdvanced Science, Volume 12, Issue 23, June 20, 2025.
Intratracheal neomycin alters pulmonary microbiota, activating the vagus nerve via lung brain‐derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) pathway, further projecting to nucleus of solitary tract (NTS), then dorsal raphe nucleus (DRN), where activated serotoninergic neurons increase brain serotonin, alleviating migraine.
Biying Liu   +7 more
wiley   +1 more source

Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide‐modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia

open access: yesAdvanced Science, Volume 12, Issue 22, June 12, 2025.
Bacterial pneumonia is the sixth leading cause of death. In this study, an inhalable polymeric nanoparticle NPFCPS‐P is developed, which under US stimulation showed high efficacy in the treatment of acute bacterial pneumonia. This nanoplatform would be much less prone to select bacterial resistance and represented a promising measure for antibiotics ...
Lin Wang   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy