Results 101 to 110 of about 1,649 (147)
Advanced Science, Volume 12, Issue 14, April 10, 2025.The strategy of ultra‐small Pd loaded covalent organic framework combined with NIR irradiation (TP@Pd+NIR) is developed to reprogram lung redox homeostasis for the synergistic enhancement of acute lung injury immunotherapy via ROS scavenging, M2 directional polarization, NF‐κB pathway inhibition as well as tissue repair acceleration.
Doudou Lei +22 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 707-717, April 2025.We conducted clinical characterization studies and performed virological evaluations on mice infected with SARS‐CoV‐2 prototype and Omicron BA.1 using RT‐PCR, HE and immunohistochemistry staining. We also studied the alterations of neutrophils and monocytes caused by the two strains using complete blood count, immunohistochemistry, and flow cytometry ...
Na Rong +8 more
wiley +1 more source
Impact of fetal treatments for congenital diaphragmatic hernia on lung development
The Anatomical Record, Volume 308, Issue 4, Page 1066-1081, April 2025.Abstract The extent of lung hypoplasia impacts the survival and severity of morbidities associated with congenital diaphragmatic hernia (CDH). The alveoli of CDH infants and in experimental models of CDH have thickened septa with fewer type II pneumocytes and capillaries. Fetal treatments of CDH‐risk preterm birth.
Mar Janna Dahl +5 more
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 4, April 2025.ATG16L1‐deficient macrophages exhibited impaired LC3B lipidation and accumulation of ROS, resulting in the activation of the NLRP3 inflammasome. Overactivated ATG16L1‐deficient macrophages aggravated the damage of alveolar epithelial cells, and increased the release of dsDNA.
Yan Bai +9 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 4, April 2025.Ganodermanontriol, the primary triterpenoid identified in Ganoderma lucidum, was evaluated for its efficacy against pneumonia through network pharmacology, molecular docking, and in vivo rat models. The compound significantly reduced lung tissue damage and inflammatory mediators by targeting the TNF/NF‐κB/MAPKs signaling pathways.
Shizhan Deng +9 more
wiley +1 more source
Adoptive Transfer of T Cells as a Potential Therapeutic Approach in the Bleomycin‐Injured Mouse Lung
The Journal of Gene Medicine, Volume 27, Issue 4, April 2025.This study explores the potential of T cells as a therapeutic strategy against idiopathic pulmonary fibrosis (IPF), a progressive lung disease for which there is currently no treatment to reverse fibrosis or restore normal lung function. To investigate an innovative approach using adoptive T cell transfer, T cells isolated from healthy mice were ...
Seyran Mutlu +6 more
wiley +1 more source
Journal of Medical Virology, Volume 97, Issue 4, April 2025.ABSTRACT Regulatory T cells (Tregs) play a vital role in limiting inflammation and resolving the immune response after a viral infection. Within the central nervous system (CNS), Tregs are especially important for the protection of neurons, which have limited regenerative capacity, and the preservation of myelin sheaths, which support neuronal function
Vivek R. Singh, Lauren A. O'Donnell
wiley +1 more source
Airway Management With Congenital Tracheal Stenosis: Surgical and Anesthetic Consideration
The Laryngoscope, Volume 135, Issue 4, Page 1506-1510, April 2025.Congenital tracheal stenosis (CTS) is a rare life‐threatening condition. Comorbidities such as various cardiac defects, prematurity, and genetic disorders would complicate the treatment options. Early surgical treatment with a cardiopulmonary bypass machine provides favorable outcomes in large, experienced centers. Objectives To investigate demographic
Sawita Kanavitoon +2 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 796-806, April 2025.ABSTRACT Predicting human lung exposure with reasonable certainty of orally inhaled drugs based on preclinical studies remains a challenge for drug development. We have developed a comprehensive physiologically based pharmacokinetic (PBPK) framework tailored for the pulmonary pharmacokinetic (PK) behavior in both humans and rats, aiming to bridge the ...
Haini Wen +3 more
wiley +1 more source
Endotracheal Actinomycosis Combined With Mucormycosis: A Case Report and Literature Review
Respirology Case Reports, Volume 13, Issue 4, April 2025.We report a case of endobronchial pulmonary actinomycosis complicated with mucormycosis. ABSTRACT Actinomycosis and mucormycosis are rare infections, and their coexistence in a single host is extremely uncommon. Actinomycosis of the trachea is a chronic septic condition caused by actinomycete infection, often misdiagnosed due to the difficulty of ...
Zhujun Chen +7 more
wiley +1 more source