Results 71 to 80 of about 76,183 (332)

A cohort evaluation of clinical use and performance characteristics of Ambu® AuraGain™: A prospective observational study

open access: yesIndian Journal of Anaesthesia, 2017
Background and Aims: Ambu® AuraGain™ (AG) (Ambu, Ballerup, Denmark) is a supraglottic device which has a design facilitating its use as a conduit for intubation.
Devangi A Parikh   +3 more
doaj   +1 more source

Investigation of effects of two environmental heavy metals in a combined exposure model on the nervous system in rats [PDF]

open access: yes, 2012
In the present study, the interaction of inhalational and oral exposure to manganese and lead was investigated. Young adult male Wistar rats (2 x 10 per group) were treated orally with MnCl2 (15 and 60 mg/kg b.w.) or Pb acetate (80 and 320 mg/kg) for 3 ...
Horváth, Edina   +3 more
core  

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

open access: yesAdvanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu   +10 more
wiley   +1 more source

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]

open access: yes, 2011
BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L   +10 more
core   +1 more source

Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle [PDF]

open access: yes, 2006
Mycobacterium bovis is the causative agent of bovine tuberculosis, a disease that is increasing in incidence in United Kingdom cattle herds. In addition to increasing economic losses, the rise in bovine tuberculosis poses a human health risk. There is an
Hope, J C, Howard, C J, Sopp, P
core   +2 more sources

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

open access: yesAdvanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen   +10 more
wiley   +1 more source

Alteração da pressão intra-cuff do tubo endotraqueal após mudança da posição em pacientes sob ventilação mecânica Endotracheal tube cuff pressure alteration after changes in position in patients under mechanical ventilation

open access: yesJornal Brasileiro de Pneumologia, 2008
OBJETIVO: O objetivo deste trabalho foi investigar a alteração da pressão intra-cuff (Pcuff) do tubo endotraqueal em pacientes sob ventilação mecânica, após alteração de sua posição corporal.
Armando Carlos Franco de Godoy   +2 more
doaj   +1 more source

Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung

open access: yesAntioxidants, 2016
NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor.
M. Horie   +10 more
semanticscholar   +1 more source

Intratracheal administration of third-generation lentivirus vector encoding MPT51 from Mycobacterium tuberculosis induces specific CD8+ T-cell responses in the lung [PDF]

open access: yes, 2008
The present study evaluates the potential of improved third-generation lentivirus vector with respect to their use as an in vivo-administered T-cell vaccine against tuberculosis.
Chida, Kingo   +8 more
core   +1 more source

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

open access: yesAdvanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji   +12 more
wiley   +1 more source

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