Results 81 to 90 of about 58,052 (292)

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Comparing the posture and comfort of anaesthesiologists during laryngoscopy and tracheal intubation in the head-elevated laryngoscopy position in supine position and with a 25° backup: A randomised clinical crossover trial

Indian Journal of Anaesthesia
Background and Aims: The head-elevated laryngoscopy position (HELP) and a 25° backup have been proposed to enhance glottic visualisation, yet concerns about ergonomic discomfort hinder their widespread adoption.
R Mookambika, RV Hemanth Kumar, Archana Areti, V Jaya   +3 more
doaj   +1 more source

Microgel Aspect Ratio Influences Injectable Granular Hydrogel Scaffold Pore Structure and Cellular Invasion for Tissue Repair

Advanced Science, EarlyView.
Granular hydrogels are being developed for the repair of tissues, mostly with the use of spherical microgels. Here, injectable granular hydrogels formed from anisotropic particles (i.e., rod‐like) are explored to improve cellular invasion by increasing scaffold void volume fraction.
Gabriel J. Rodriguez‐Rivera, Siddharth Sharma, Chima V. Maduka, Sara Boyd, Amy R. Perry, Nikolas Di Caprio, Lindsay Riley, Connor E. Miksch, Daeyeon Lee, Tatiana Segura, David Issadore, Jason A. Burdick   +11 more
wiley   +1 more source

Oral Endotracheal Intubation with Restricted Glottis View using C-MAC D Blade®: A Randomised Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The perspective of airway management has undergone a considerable transformation since the advent of Video Laryngoscopes (VL). VL has rapidly been accepted as an intubation tool in a variety of clinical scenarios.
Vaidarbhi Rasikbhai Patel, Nirali Nimeshkumar Panchal, Sanket Hirenbhai Mehta, Madhavi Sanjay Chaudhari, Bhumika Pradipkumar Pathak, Mayur Kiran shinde   +5 more
doaj   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Comparison of dental force applied during endotracheal intubation with hyper-angulated and macintosh-type video laryngoscopy blades used by emergency medicine trainees: A randomized cross-over manikin study

Turkish Journal of Emergency Medicine
OBJECTIVES: This study aimed to compare the effects of Macintosh-type and hyperangulated video laryngoscopy (VL) blades on dental force during endotracheal intubation (ETI) using Glidescope and McGrath VL devices.
Ali Rıza Karabacak, İbrahim Ulaş Özturan, Ömer Faruk Şefoğlu, Nurettin Özgür Doğan, Elif Yaka, Serkan Yılmaz, Murat Pekdemir   +6 more
doaj   +1 more source

Phenylboronic Acid‐Modified Copper Nanozymes as Nanoscavengers of Bacterial Polysaccharides Causing Acute Lung Injury

Advanced Science, EarlyView.
A novel copper nanocluster coated with 4‐mercaptobenzeneboronic acid (CuMPBA) is developed to target bacterial polysaccharides for addressing complicated acute lung injury (ALI) caused by severe burns and early pulmonary infections. CuMPBA exhibits dual anti‐inflammatory and antibacterial mechanisms by: (a) binding and degrading toxic bacterial ...
Haojie Ge, Min Wang, Haijiao Xie, Xu‐Lin Chen, Xianwen Wang   +4 more
wiley   +1 more source

High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung [PDF]

, 2018
The bacterial second messenger bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) has been shown to influence the expression of virulence factors in certain pathogenic bacteria, but little is known about its activity in the increasingly antibiotic-resistant ...
Hunstad, David A, Rosen, David A, Twentyman, Joy   +2 more
core   +2 more sources

Intratracheal instillation versus intratracheal inhalation: influence of cytokines on inflammatory response.

Environmental Health Perspectives, 1997
Our laboratory has developed a method of particle exposure whereby anesthetized rats intratracheally inhale, at a regulated breathing rate and pressure, an aerosolized test material. This method is capable of delivering considerable doses in a short time period and, unlike the commonly used method of intratracheal instillation, does so with an even ...
Raymond B. Baggs, Günter Oberdörster, M Osier   +2 more
openaire   +3 more sources

Bimetal‐Phenolic Framework to Combat Bacterial Infections via Synergistic Biofilm Dispersal, Bacterial Killing and Immune Modulation

Advanced Science, EarlyView.
A bimetal‐phenolic framework (Que‐Fe‐CeMPF) is developed by direct self‐assembly through the coordination of Fe3+ and Ce4+ with quercetin. Que‐Fe‐CeMPF exhibits multimodal activity, including cleaving matrix eDNA within biofilm, generating hydroxyl radicals via catalytic H2O2 to kill bacteria, and alleviating inflammation by stimulating macrophage ...
Yaran Wang, Fan Wu, Lei Hua, Chang Gao, Siran Wang, Yong Liu, Yijin Ren, Linqi Shi, Henny C. van der Mei, Yuanfeng Li   +9 more
wiley   +1 more source