Results 91 to 100 of about 51,241 (251)

Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial [PDF]

, 2009
<p><b>Background and Purpose:</b>Although magnesium is neuroprotective in animal stroke models, no clinical benefit was confirmed in the Intravenous Magnesium Efficacy in Stroke (IMAGES) trial of acute stroke patients.
Alger, J.R., Chen, C., Davis, S.M., De Silva, D.A., Kidwell, C.S., Lees, K.R., Muir, K.W., Saver, J.L., Starkman, S., Weir, C.J.   +9 more
core   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Higher fibrinogen and neutrophil-to-lymphocyte ratio are associated with the early poor response to intravenous thrombolysis in acute ischemic stroke

Frontiers in Neurology
BackgroundInflammation and platelet activation play pivotal roles in acute ischemic stroke (AIS) pathogenesis. Early response to thrombolysis is a vital indicator for the long-term prognosis of AIS.
Mingzhu Deng, Kangping Song, Yangping Tong, Sufen Chen, Wei Xu, Guohua He, Jue Hu, Hui Xiao, Changmin Wan, Zhen Wang, Fangyi Li   +10 more
doaj   +1 more source

Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset [PDF]

, 2010
<p><b>Background and Purpose:</b> Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.</p> <p><b>Methods:</b> We ...
Ahmed, N., Diedler, J., Ford, G.A., Lees, K.R., Luijckx, G.J., Overgaard, K., Ringleb, P., Soinne, L., Sykora, M., Uyttenboogaart, M., Wahlgren, N.   +10 more
core   +2 more sources

Incidence and In‐Hospital Mortality of Ventricular Septal Rupture Following Acute Myocardial Infarction

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Ventricular septal rupture (VSR) is a rare but devastating complication of acute myocardial infarction (MI), associated with high mortality despite advances in reperfusion therapy. However, contemporary data examining national trends in VSR outcomes and the evolving role of mechanical circulatory support (MCS) in this population ...
Javier Fernandez, Namra Khan, Muni Rubens, Dorsa Majdpour, Masood Azhar, Mukesh Roy, Anshul Saxena, Sandra Chaparro, Javier Jimenez   +8 more
wiley   +1 more source

Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography [PDF]

, 2011
Accurate identification of ischemic penumbra will improve stroke patient selection for reperfusion therapies and clinical trials. Current magnetic resonance imaging (MRI) techniques have limitations and lack validation.
Barrie Condon, Celestine Santosh, Christopher McCabe, Craig A Robertson, I Mhairi Macrae, Keith W Muir, Kucinski T, Lindsay Gallagher, Maria del Rosario Lopez-Gonzalez, William M Holmes   +9 more
core   +1 more source

Intraocular hemorrhage in patients misdiagnosed with central retinal artery occlusion treated with thrombolysis

Frontiers in Neurology
IntroductionThe diagnosis of acute central retinal artery occlusion (CRAO) is commonly delayed in emergency departments (ED) where ophthalmologists are rarely available for immediate consultation.
Daniel V. Adamkiewicz, Christian Leal, Kevin Y. Yan, Sruthi Arepalli, Kevin Ferenchak, Blaine Cribbs, Riley J. Lyons, Étienne Bénard-Séguin, Étienne Bénard-Séguin, Étienne Bénard-Séguin, Nancy J. Newman, Nancy J. Newman, Nancy J. Newman, Valérie Biousse, Valérie Biousse   +14 more
doaj   +1 more source

Mean Platelet Volume-To-Lymphocyte Ratio Predicts Poor Functional Outcomes Among Ischemic Stroke Patients Treated With Intravenous Thrombolysis

Frontiers in Neurology, 2019
Background and Purpose: According to previous studies, the mean platelet volume-to-lymphocyte ratio (MPVLR) represents a novel marker of a poor short-term prognosis in patients with a myocardial infarction who underwent primary percutaneous coronary ...
Si-Yan Chen, Yuan-Shao Lin, Yi-Fan Cheng, Hong Wang, Xiao-Ting Niu, Wan-Li Zhang   +5 more
doaj   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Intravenous Thrombolysis [PDF]

International Journal of Stroke, 2010
Thang H, Nguyen, Anh T L, Truong, Minh Ba, Ngo, Chau T Q, Bui, Quang V, Dinh, Tan C, Doan, Lien T K, Nguyen, Tan C, Phan, Mung V, Phan, Tuan V, Nguyen, Thanh V, Le   +10 more
openaire   +3 more sources