Results 61 to 70 of about 3,579,241 (217)

Inferring function using patterns of native disorder in proteins [PDF]

, 2007
Natively unstructured regions are a common feature of eukaryotic proteomes. Between 30% and 60% of proteins are predicted to contain long stretches of disordered residues, and not only have many of these regions been confirmed experimentally, but they ...
Swindells, MB, Jones, DT, Mark B. Swindells, David T. Jones, Lobley, A, Lobley, A., Christine A. Orengo, David T Jones, Mark B Swindells, Swindells, M.B., Orengo, C.A., Christine A Orengo, Jones, D.T., Anna Lobley, Orengo, CA   +14 more
core   +2 more sources

Globular and disordered – the non-identical twins in protein-protein interactions

Frontiers in Molecular Biosciences, 2015
In biology proteins from different structural classes interact across and within classes in ways that are optimized to achieve balanced functional outputs.
Kaare eTeilum, Johan G. Olsen, Birthe B. eKragelund   +2 more
doaj   +1 more source

Low-resolution description of the conformational space for intrinsically disordered proteins

Scientific Reports, 2022
Intrinsically disordered proteins (IDP) are at the center of numerous biological processes, and attract consequently extreme interest in structural biology.
Daniel Förster, Jérôme Idier, Leo Liberti, Antonio Mucherino, Jung-Hsin Lin, Thérèse E. Malliavin   +5 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Protein intrinsically disordered region prediction by combining neural architecture search and multi-objective genetic algorithm

BMC Biology, 2023
Background Intrinsically disordered regions (IDRs) are widely distributed in proteins and related to many important biological functions. Accurately identifying IDRs is of great significance for protein structure and function analysis.
Yi-Jun Tang, Ke Yan, Xingyi Zhang, Ye Tian, Bin Liu   +4 more
doaj   +1 more source

Engagement of intrinsic disordered proteins in protein–protein interaction

Frontiers in Molecular Biosciences, 2023
Proteins from the intrinsically disordered group (IDP) focus the attention of many researchers engaged in protein structure analysis. The main criteria used in their identification are lack of secondary structure and significant structural variability ...
Irena Roterman, Katarzyna Stapor, Leszek Konieczny   +2 more
doaj   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome [PDF]

, 2013
A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame.
Kalmár, Lajos, Schád, Éva, Tompa, Péter   +2 more
core   +1 more source

Martini3-IDP: improved Martini 3 force field for disordered proteins

Nature Communications
Coarse-grained (CG) molecular dynamics (MD) is widely used for the efficient simulation of intrinsically disordered proteins (IDPs). The Martini model, one of the most popular CG force fields in biomolecular simulation, was reported to yield too compact ...
Liguo Wang, Christopher Brasnett, Luís Borges-Araújo, Paulo C. T. Souza, Siewert J. Marrink   +4 more
doaj   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source