Results 81 to 90 of about 3,579,241 (217)

Brain Expressed and X-Linked (Bex) Proteins Are Intrinsically Disordered Proteins (IDPs) and Form New Signaling Hubs

PLOS ONE, 2015
Intrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation. The family of Brain Expressed and X-linked (Bex) proteins consists of 5 members in humans (Bex1-5).
Fernandez, Eva M, Díaz-Ceso, María D, Vilar, Marçal   +2 more
openaire   +5 more sources

Role of charges in a dynamic disordered complex between an IDP and a folded domain

Nature Communications
Protein complexes involving intrinsically disordered proteins (IDPs) cover a continuum from IDPs that fully fold upon binding to IDPs that remain fully disordered in the complex. Here we demonstrate a case of charge-driven interactions of a folded domain
Katrine Bugge, Andrea Sottini, Miloš T. Ivanović, Freia S. Buus, Daniel Saar, Catarina B. Fernandes, Fabienne Kocher, Jacob H. Martinsen, Benjamin Schuler, Robert B. Best, Birthe B. Kragelund   +10 more
doaj   +1 more source

Structural investigation of Rett-inducing MeCP2 mutations

Genes and Diseases, 2019
X-ray structure of methyl-CpG binding domain (MBD) of MeCP2, an intrinsically disordered protein (IDP) involved in Rett syndrome, offers a rational basis for defining the spatial distribution for most of the sites where mutations responsible of Rett ...
Ottavia Spiga, Simone Gardini, Nicole Rossi, Vittoria Cicaloni, Francesco Pettini, Neri Niccolai, Annalisa Santucci   +6 more
doaj   +1 more source

Empirical predictions of an intrinsically disordered protein theory approach to glycan/lectin reaction kinetics [PDF]

, 2012
Newly-developed methods from the theory of intrinsically disordered proteins can be applied to the flexible glycan structures that coat cellular surfaces and provide rich channels for biological information transmission.
Rodrick Wallace
core  

Toward a consensus in protein structure nomenclature

, 2019
In a recent article, published in Intrinsically Disordered Proteins, a valuable consensus view regarding the nomenclature for disordered proteins was presented.1 In this work the authors present a thoughtful and systemic review of terms that have been ...
DaSilva, Linder C, Gurry, Thomas Jerome, Stultz, Collin M   +2 more
core   +1 more source

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

Unequivocal single-molecule force spectroscopy of intrinsically disordered proteins [PDF]

, 2012
Intrinsically disordered proteins (IDPs) are predicted to represent about one third of the eukaryotic proteome. The dynamic ensemble of conformations of this steadily growing class of proteins has remained hardly accessible for bulk biophysical ...
Rubén Hervás, Carrión-Vázquez, Mariano Sixto, Carrión-Vázquez, Mariano, Oroz, Javier, Valbuena, Alejandro, Hervás, Rubén, Javier Oroz, Alejandro Valbuena, Mariano Carrión-Vázquez   +8 more
core   +1 more source

Accurate and Fast Prediction of Intrinsically Disordered Protein by Multiple Protein Language Models and Ensemble Learning

, 2023
Intrinsically disordered proteins (IDPs) play a vital role in various biological processes and have attracted increasing attention in the past few decades. Predicting IDPs from the primary structures of proteins offers a rapid and facile means of protein
Akira Onoda, Akira Onoda (1470163), Shijie Xu, Shijie Xu (3324546)   +3 more
core   +1 more source

An ETL pipeline to construct the Intrinsically Disordered Proteins Knowledge Graph (IDP-KG) using Bioschemas JSON-LD data dumps

, 2022
Schema.org and Bioschemas are lightweight vocabularies that aim at making the contents of web pages machine-readable so that software agents can consume that content and understand it in an actionable way. Due to the time needed to process each page, extracting markup by visiting each page of a site is not practical for huge sites.
Ammar Ammar, Ivan Mičetić, Alasdair J. G. Gray   +2 more
openaire   +1 more source