Results 81 to 90 of about 4,606,382 (149)

Determinants for intrinsically disordered protein recruitment into phase-separated protein condensates

, 2022
Multivalent interactions between amino acid residues of intrinsically disordered proteins (IDPs) drive phase separation of these proteins into liquid condensates, forming various membrane-less organelles in cells.
Jang, Jinyoung, Jung, Yongwon, Song, Daesun, Park, Hyoin, Jo, Yongsang   +4 more
core   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

EPR in protein science : intrinsically disordered proteins

, 2011
Intrinsically disordered proteins (IDPs) form a unique protein category characterized by the absence of a well-defined structure and by remarkable conformational flexibility.
Drescher, Malte, Malte Drescher
core   +1 more source

Effects of macromolecular crowding on an intrinsically disordered protein [PDF]

, 2022
Proteins are composed of amino acids, and usually have one native structure. Intrinsically disordered proteins lack a native structure and can populate many different forms, making them ideal for binding.
Hadfield, Andrew
core   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, Volume 13, Issue 62, 9 November 2026.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Inferring function using patterns of native disorder in proteins [PDF]

, 2007
Natively unstructured regions are a common feature of eukaryotic proteomes. Between 30% and 60% of proteins are predicted to contain long stretches of disordered residues, and not only have many of these regions been confirmed experimentally, but they ...
Swindells, MB, Jones, DT, Mark B. Swindells, David T. Jones, Lobley, A, Lobley, A., Christine A. Orengo, David T Jones, Mark B Swindells, Swindells, M.B., Orengo, C.A., Christine A Orengo, Jones, D.T., Anna Lobley, Orengo, CA   +14 more
core   +2 more sources

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, Volume 38, Issue 59, 22 October 2026.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Rethinking Gene Regulatory Networks in Light of Alternative Splicing, Post-Translational Modifications, and Intrinsically Disordered Protein Domains

Frontiers in Cell and Developmental Biology, 2015
Models for genetic regulation and cell fate specification characteristically assume that gene regulatory networks (GRNs) are essentially deterministic and exhibit multiple stable states specifying alternate, but pre-figured cell fates. Mounting evidence
Karl J. Niklas, Sarah eBondos, A. Keith eDunker, Stuart A. Newman   +3 more
doaj   +1 more source

An ETL pipeline to construct the Intrinsically Disordered Proteins Knowledge Graph (IDP-KG) using Bioschemas JSON-LD data dumps

, 2022
Schema.org and Bioschemas are lightweight vocabularies that aim at making the contents of web pages machine-readable so that software agents can consume that content and understand it in an actionable way. Due to the time needed to process each page, extracting markup by visiting each page of a site is not practical for huge sites.
Ammar Ammar, Ivan Mičetić, Alasdair J. G. Gray   +2 more
openaire   +1 more source