Results 81 to 90 of about 5,123 (214)

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

Simulation of coupled folding and binding of an intrinsically disordered protein in explicit solvent with metadynamics

, 2016
The C-terminal domain of measles virus nucleoprotein is an intrinsically disordered protein that could bind to the X domain (XD) of phosphoprotein P to exert its physiological function.
Li, Jinghai, Ren, Ying, Han, Mengzhi, Xu, Ji   +3 more
core   +1 more source

Dynamics of proteins with different molecular structures under solution condition

Scientific Reports, 2020
Incoherent quasielastic neutron scattering (iQENS) is a fascinating technique for investigating the internal dynamics of protein. However, low flux of neutron beam, low signal to noise ratio of QENS spectrometers and unavailability of well-established ...
Rintaro Inoue, Takashi Oda, Hiroshi Nakagawa, Taiki Tominaga, Tomohide Saio, Yukinobu Kawakita, Masahiro Shimizu, Aya Okuda, Ken Morishima, Nobuhiro Sato, Reiko Urade, Mamoru Sato, Masaaki Sugiyama   +12 more
doaj   +1 more source

PolyProline Predictor: A web server for empirical sequence‐based prediction of polyproline II helices

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Polyproline II (PPII) helices are extended left‐handed secondary structures increasingly recognized for their roles in molecular recognition, signaling and within intrinsically disordered regions of proteins. Despite their functional importance, predicting regions with propensity to form PPII helices from sequence alone remains challenging due
Rubén López‐Sánchez, David Pantoja‐Uceda, Miguel Mompeán, Douglas V. Laurents   +3 more
wiley   +1 more source

Structural investigation of Rett-inducing MeCP2 mutations

Genes and Diseases, 2019
X-ray structure of methyl-CpG binding domain (MBD) of MeCP2, an intrinsically disordered protein (IDP) involved in Rett syndrome, offers a rational basis for defining the spatial distribution for most of the sites where mutations responsible of Rett ...
Ottavia Spiga, Simone Gardini, Nicole Rossi, Vittoria Cicaloni, Francesco Pettini, Neri Niccolai, Annalisa Santucci   +6 more
doaj   +1 more source

AlphaFold2 modeling and molecular dynamics simulations of an intrinsically disordered protein.

PLoS ONE
We use AlphaFold2 (AF2) to model the monomer and dimer structures of an intrinsically disordered protein (IDP), Nvjp-1, assisted by molecular dynamics (MD) simulations.
Hao-Bo Guo, Baxter Huntington, Alexander Perminov, Kenya Smith, Nicholas Hastings, Patrick Dennis, Nancy Kelley-Loughnane, Rajiv Berry   +7 more
doaj   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

Conformational Entropy of Intrinsically Disordered Protein

, 2016
Intrinsically disordered proteins (IDPs), though lacking stable tertiary structures, are known to possess a certain amount of residual structure. Conformational disorder plays a crucial role through the conformational entropy in regulating protein ...
Sihyun Ham (1499494), Song-Ho Chong (1521088)   +1 more
core   +1 more source

IDPpi:Protein-protein interaction analyses of human intrinsically disordered proteins [PDF]

, 2018
Intrinsically disordered proteins (IDPs) are characterized by the lack of a fixed tertiary structure and are involved in the regulation of key biological processes via binding to multiple protein partners.
Marsh, Lindsey A., Radovanovic, Sandro, Veljković, Nevena V., Sumonja, Neven, Roberts, Stefan G.E., Veljkovic, Nevena, Perović, Vladimir R., Perovic, Vladimir, Roberts, Stefan G. E., Vukicevic, Milan   +9 more
core   +1 more source

An ETL pipeline to construct the Intrinsically Disordered Proteins Knowledge Graph (IDP-KG) using Bioschemas JSON-LD data dumps

, 2022
Schema.org and Bioschemas are lightweight vocabularies that aim at making the contents of web pages machine-readable so that software agents can consume that content and understand it in an actionable way. Due to the time needed to process each page, extracting markup by visiting each page of a site is not practical for huge sites.
Ammar Ammar, Ivan Mičetić, Alasdair J. G. Gray   +2 more
openaire   +1 more source