Results 101 to 110 of about 4,606,382 (149)
Many-to-one binding by intrinsically disordered protein regions
, 2019 Disordered binding regions (DBRs), which are embedded within intrinsically disordered proteins or regions (IDPs or IDRs), enable IDPs or IDRs to mediate multiple protein-protein interactions.
Andrzej Kloczkowski +19 more
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eLifeThe conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins, combined with the exposure of their residues, accounts for this ...
Shraddha KC +9 more
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Conformational Entropy of Intrinsically Disordered Protein
, 2016 Intrinsically disordered proteins (IDPs), though lacking stable tertiary structures, are known to possess a certain amount of residual structure. Conformational disorder plays a crucial role through the conformational entropy in regulating protein ...
Sihyun Ham (1499494) +1 more
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Nature CommunicationsResidue-level coarse-grained (CG) molecular dynamics (MD) simulation is widely used to investigate slow biological processes that involve multiple proteins, nucleic acids, and their complexes. Biomolecules in a large simulation system are distributed non-
Jaewoon Jung, Cheng Tan, Yuji Sugita
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Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold
Advanced ScienceIntrinsically disordered proteins (IDPs) play pivotal roles in various biological functions whose dynamic structures are closely associated with many human diseases, including cancer, diabetes, and Alzheimer disease.
Junjie Zhu +10 more
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Abstract Self-organization of multicellular systems is vital for building structure in living system but remains underexplored in engineered living materials. We developed iDP 2 , a platform enabling high-density display of intrinsically disordered proteins on the surface of
Rong Chang, Hann Tu, Neel S. Joshi
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INTRINSICALLY DISORDERED PROTEINS (IDPS) IN HUMAN DISEASES: A REVIEW
International Research Journal Of Pharmacy, 2018 openaire +1 more source
Conformational dynamics and association of intrinsically disordered proteins (IDPs) using molecular dynamics simulationsNo 2nd Integrative Structural Biology ...
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Assessment of Missense Intolerant Regions (MIRs) in Intrinsically Disordered Proteins (IDPs)
Genes that are crucial for the function of an organism are depleted of disrupting variants in natural populations, whereas non-essential genes tolerate their accumulation. Next-generation sequencing (NGS) of the general population has enabled comprehensive coverage of the human genome, identifying single nucleotide variants (SNVs) at an impressive ...
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